28/01/2026
π« Chest Pain Localization β Clinical Patterns & Differential Diagnosis
Chest pain must always be approached systematically because several causes are life-threatening.
π΄ Acute Myocardial Infarction (AMI)
Pain character
β Crushing, pressure-like, retrosternal
Radiation
β Left arm
β Neck / jaw
β Sometimes epigastrium or back
Associated features
β Diaphoresis
β Nausea / vomiting
β Dyspnea
β Anxiety
Mechanism
β Myocardial ischemia due to coronary artery occlusion
Exam pearl
β Pain NOT relieved by position or respiration
β Always treat as emergency.
π« Pulmonary Embolism (PE)
Pain character
β Sharp, pleuritic (worse on inspiration)
Location
β Usually lateral or posterior chest
Associated features
β Sudden dyspnea
β Tachycardia
β Hypoxia
β Β± Hemoptysis
Mechanism
β Pulmonary arterial obstruction β lung infarction
Exam pearl
β Pleuritic pain + tachycardia + dyspnea = think PE.
π Pericarditis
Pain character
β Sharp, central chest pain
Radiation
β Trapezius ridge / upper back
Positional changes
β Worse supine
β Relieved by sitting forward
Mechanism
β Inflammation of pericardium
Exam pearl
β Pain improves leaning forward (unique feature).
π§ Pneumothorax
Pain character
β Sudden unilateral pleuritic pain
Associated features
β Dyspnea
β Reduced breath sounds on affected side
Mechanism
β Air in pleural space β lung collapse
Exam pearl
β Sudden chest pain + breathlessness in young patient β suspect pneumothorax.
π¨ Esophageal Pain (GERD / Spasm)
Pain character
β Burning or squeezing retrosternal pain
Radiation
β Mid-back
Triggers
β Swallowing
β Reflux
β Lying flat
Mechanism
β Acid reflux or esophageal spasm
Exam pearl
β Can mimic MI β differentiate by relation to meals.
π© Musculoskeletal / Thoracic Radiculopathy
Pain character
β Localized chest wall pain
Key feature
β Reproducible with movement or palpation
Distribution
β Dermatomal pattern possible
Mechanism
β Muscle strain or nerve root irritation
Exam pearl
β Reproducible pain = usually non-cardiac.
π¨ Red-Flag Chest Pain (Always Rule Out First)
β Myocardial infarction
β Pulmonary embolism
β Pneumothorax
β Aortic dissection (not shown but critical)