12/03/2026
What was the Trilogiii Human Study?
Terminology: Although it is correct to call the Trilogiii Human Study a “Clinical Trial” as it specifically falls into the “Decentralized Trial” category, we at Triii Therapeutics prefer the term “Human Study” as it doesn’t incorrectly conjure up images of hospitals, labs, blood tests, and petri dishes. We aim to never mislead people.
Type of Study: The study was formally a Before / During / After “Single-Group” study that measured beginning baseline data and compared it to in-progress and final data. With this type of study, participants serve as their own controls, comparing their results before administration to their results during and after administration.
Ethical / Practical Constraints: By structure, this type of study does not require a control group. The scientific community also recognizes that many types of studies are not practical for a control group (like trying to produce convincing placebo versions of all five of the Trilogiii products in the study protocol) or would be unethical to do so (where people are looking for real metrics and health results not achievable through a placebo regimen.)
Facebook Group: The "Trilogiii Health - Discussions & Testimonials“ Facebook group (since renamed, "Trilogiii Health Community") was a formal part of the study, with study participants required to be members. The group allowed for additional information, clarification, encouragement, and feedback. It also served to facilitate further data capture and provide an easily accessible secondary-source validation of study integrity. Over 300 participants shared corroborating data openly in the group.
Number of Participants: The formal study involved 500 participants.
Duration: The formal study lasted 12 weeks, but with a much smaller, but statistically significant, subset opting to continue for 16 weeks. Many individuals reached their weight loss goals within 8 weeks, allowing for the study to also assess maintenance data.
Study Packets: Participants received one-month (four week) study packets consisting of 60 pages, including a confidential cover sheet, detailed product descriptions, ingredient modes of action, supplement facts panels, extensive long-form FAQ’s, protocol explanations, easy-reference protocol usage guides, demographic information, personal initial assessments, data recording sheets (daily, weekly, and final), and a product usage / preference survey. Participants subsequently received two-month (eight week) study packets with the same information and reporting requirements.
Personal Info / Initial Assessments: Study participants confidentially shared demographic information, general health goals, weight loss goals, past or current hormone inventions and / or GLP-1 RA drug use (to be discontinued for the duration of the study), and GLP-1 RA response levels and side effects experienced. Participants also confidentially reported detailed medical histories and disease conditions as well as current medications and dietary supplement usage. Personal health assessments included matrices to report overall health, diet / nutrition, mood, energy levels, activity levels, exercise frequency, stress levels, focus / attention, sleep quantity and quality, water consumption, food noise, hunger levels, and food cravings. Participants also reported any additional use of fasting and dietary regimens.
Data Recording Sheets: Participants tracked daily Trilogiii usage, in full or in part. They further reported days of meal replacements, smaller-than-normal meal sizes, lean protein and low-carb vegetable meals, formal fasting regimen inclusion, and meal timing data. Other items reported included water consumption, exercise, and sleep. Weekly summaries included progress metrics (weight & measurements), desire indicators (to eat healthier and to exercise more), perceived health improvement factors / multiples (including overall health, diet / nutrition, quality of sleep, mood, energy levels, activity levels, focus / attention). Additional factors included perceived hunger, cravings, and food noise improvements. The Data Recording Sheets also enabled participants to share detailed written observations within each category.
Subjective Response Techniques: The Data Recording Sheets employed numerous techniques to record subjective data, including semantic redundancy, multi-item scale, converging operations, and intra-item validity. Furthermore, reverse phrasing / coding and matrix formats were also utilized. All combined, these techniques allowed us to determine response reliability and consistency, discount “cheating” or “lazy recording” factors, and assure better overall accuracy.
Confidentiality: Formal study data sheets were received by an independent law firm that stripped off the cover sheets which contained participant names. The law firm provided Triii Therapeutics with the participant names, but not the actual cover sheets, to prevent the matching of ink and writing styles. Triii therefore had / has no ability to ever match participant names with participant data. Any results shared openly in the private Facebook group, although accessible by any new members, are likewise confidential and were / are not permitted to be posted outside of the group with any identifying personal information.
Corroborating Data: The private Facebook group initially involved 316 people sharing 646 sets of results, although these numbers are increasing daily as more people are also choosing to openly report their results. These results corroborate those that have been preliminarily tabulated from the formal Data Recording Sheets.
Preliminary Study Results: Based on almost 650 reported sets of data, preliminary study results reveal an average weight loss of 12.7 lbs after 4 weeks, 19.7 lbs after 8 weeks, 26.7 lbs after 12 weeks, and 35.3 lbs after 16 weeks. These results are further validated through the initial review of formal responses from 300 study participants. These results include numerous study participants who indicated they didn’t strictly adhere to the study protocol. The majority of participants met their weight loss goal within the first and second months. These are averages and individual results of course vary.
Final Results: It will take six months for the full analysis and publishing of all the available data but, as mentioned, the initial tabulation reveals that the formal Data Recording Sheets are very much congruent with the publicly reported results in the “Trilogiii Health Community” Facebook group.
Study Sponsor: The study was sponsored by an independent third party, Nelo Life (“Sponsor”), which has subsequently merged with another company. Trilogiii was never offered for general public sale by the sponsor or the company it was then acquired by. None of the owners, investors, executives or any employees of Triii served in similar roles with the sponsor or vice versa.
Study Costs: Triii Therapeutics provided all study products at manufacturing / acquisition cost. Triii assumed further costs related to protocol support and online interaction, legal fees, insurance, data receipt and summation, and near-future formal study write-ups and publication submissions. The sponsor facilitated the coverage of product costs, printing costs, software system support, product distribution, return mailing expenses, and study aids such as shake blender bottles and personal measuring tapes. The sponsor recouped these costs by charging a “Study Participant Fee” from those who participated in the study. Participant fees typically help with participant “ownership,” personal accountability, and study data recording / return compliance. Triii and the sponsor both attest that they did not earn any money from conducting the Trilogiii study. Direct study costs were ultimately borne by the participants themselves.
Study Participants: Participants were male and female persons from age 10 to 90 years. They included healthy individuals and others struggling with a variety of health conditions. Participants were required to confidentially list any medications they were taking, but to not be concurrently taking any GLP-1 RA drug regimen. Participants were recruited and sourced jointly by Triii and the sponsor through private & corporate networks and members of the general public.
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