28/01/2014
Augmentin (amoxicillin) Augmentin (amoxicillin)
Company: Company: SmithKline Beecham SmithKline Beecham Treatment for: Treatment for: sinusitis, bronchitis, pneumonia sinusitis, bronchitis, pneumonia
Important Drugs Information Important Drugs Information
A new adult dosing regimen of A new adult dosing regimen of Augmentin Augmentin has been approved. Augmentin is an has been approved. Augmentin is an antibiotic used to treat various respiratory-tract infections, including sinusitis, antibiotic used to treat various respiratory-tract infections, including sinusitis, bronchitis, and pneumonia. bronchitis, and pneumonia.
In the new regimen, Augmentin is administered twice a day (BID), every 12 hours, in In the new regimen, Augmentin is administered twice a day (BID), every 12 hours, in contrast to three-times-a-day regimen used since Augmentin was introduced in the contrast to three-times-a-day regimen used since Augmentin was introduced in the United States. United States.
The BID regimen for more severe infections and infections of the respiratory tract The BID regimen for more severe infections and infections of the respiratory tract consists of a new tablet containing 875 mg of amoxicillin and 125 mg of consists of a new tablet containing 875 mg of amoxicillin and 125 mg of clavulanate potassium. In addition, the currently marketed tablet containing 500 mg clavulanate potassium. In addition, the currently marketed tablet containing 500 mg of amoxicillin and 125 mg of clavulanate potassium can now be prescribed on a of amoxicillin and 125 mg of clavulanate potassium can now be prescribed on a twice-a-day regimen for less severe infections that may be treated with a lower twice-a-day regimen for less severe infections that may be treated with a lower dose. dose.
Augmentin should not be used in subjects with a history of allergic reactions to any Augmentin should not be used in subjects with a history of allergic reactions to any penicillin or with a previous history of Augmentin-associated cholestatic penicillin or with a previous history of Augmentin-associated cholestatic jaundice/hepatic dysfunction. jaundice/hepatic dysfunction.
Side Effects Side Effects
The side effects of Augmentin, which are primarily mild and self-limiting, include The side effects of Augmentin, which are primarily mild and self-limiting, include diarrhea and nausea. In adult subjects treated for more severe infections during diarrhea and nausea. In adult subjects treated for more severe infections during clinical trials, there was a 60% reduction in the number of subjects experiencing clinical trials, there was a 60% reduction in the number of subjects experiencing severe diarrhea or withdrawing from trials because of diarrhea. severe diarrhea or withdrawing from trials because of diarrhea.
