06/01/2026
A 2009 study investigated how short-term quercetin supplementation affects mitochondrial biogenesis in sedentary mice.
Researchers gave 25 mg/kg/day for 7 days and measured mitochondrial DNA, PGC-1α, and SIRT1 in brain and soleus muscle.
Mice receiving quercetin showed significantly increased mitochondrial DNA and markers of energy metabolism in both tissues. These changes were linked to higher cytochrome c levels and improved endurance in voluntary activity tests, indicating enhanced mitochondrial function.
The findings suggest quercetin could stimulate mitochondria and support energy production, though further research is needed to determine effects in humans. ⚡💪
Bottom Fact: Quercetin may enhance mitochondrial biogenesis and energy metabolism, potentially improving endurance and cellular energy.
Source: Davis JM, Murphy EA, Carmichael MD, Davis B. Am J Physiol Regul Integr Comp Physiol. 2009;297(5):R1223–R1231. PMID: 19211721.
Disclaimer: Study conducted in mice; human effects are not yet established.