09/27/2025
Artemisinin is an effective anti malarial TCM herb, that also has potent anti cancer properties. Artesunate (ART) is the semisynthetic derivative of artemisinin. ART has a better absorption than its natural counterpart artemisinin. This study demonstrates ART anti cancer effect on prostate cancer, but artemisinin and ART also effective for other cancers including breast, ovarian, gastric, and melanomas.
From the study:
"Recent studies have shown that ART acts on the electron transport chain (of cancer) and is directly involved in reactive oxygen species generation, which leads to mitochondrial membrane depolarization and an apoptosis response cascade.
In summary, our study is the first demonstration that lncRNA participates in the antitumor effect of ART. ART significantly inhibited the viability and mobility of PCa cell lines triggered by UCA1 down-regulation. All the described clinical data support the proposition that over-expression of UCA1 may play a key role in PCa progression and development."
https://www.oncotarget.com/article/15353/text/
https://doi.org/10.18632/oncotarget.15353 Yan Zhou, Xiuju Wang, Jianjun Zhang, Aina He, Ya Ling Wang, Kun Han, Yang Su, Junyi Yin, Xiaobin Lv, Haiyan Hu
