Princess Margaret Cancer Centre Research

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Princess Margaret Cancer Centre Research

We are the largest integrated cancer research, teaching and treatment centre in Canada

02/07/2025

The 14th Annual Princess Margaret Cancer Centre Research Retreat took place in May and focused on the theme: It takes two to think. A wide range of talks helped build collaboration between scientists and clinicians, and helped advance bench-to-bedside discoveries.

Dr. Marianne Koritzinsky received the inaugural Carry The Fire Award, in recognition of her spirit of citizenship. Dr. Koritzinsky dedicates her time and effort to supporting the people and work of our research institute.

Congratulations to all other award winners: Dr. Ming Tsao (Allan Slaight Collaborator of the Year Award), Dr. Trevor Pugh (Mona Gauthier Award), and Dr. Lillian Siu (Richard Hill Mentorship Award). This year’s Till and McCulloch Paper of the Year winners are: Dr. Razq Hakem (Discovery), Drs. Hansen He and Ming-Sound Tsao (Translational), and Dr. Laura Dawson (Clinical).

Read more in our link in bio.

20/06/2025

What’s new in lung cancer: smarter staging and scientific breakthroughs 🫁

14/04/2025

Porphysomes—a groundbreaking light-activated nanoparticle technology—has reached a pivotal milestone: Health Canada has approved the start of clinical trials.

For over a decade, researchers at UHN’s Princess Margaret Cancer Centre have been pioneering this revolutionary approach to cancer imaging and therapy.

“Porphysomes were a game-changer from the moment we discovered them,” says Dr. Gang Zheng. “Their unique ability to accumulate in tumours and respond to light makes them an incredibly powerful tool.”

Read more in our link in bio.

21/03/2025

Congratulations to our Senior Scientists Drs. John Dick and Jean Wang, and Dr. Jayne Danska from Sick Children’s Hospital Research Institute on receiving the Inventor of the Year Award, a part of the inaugural UHN Mission Excellence Awards!

They were recognized for their research in cancer immunotherapy, specifically for identifying a novel way that cancer cells evade destruction. Their research led to development of TTI-621, a SIRPα fusion protein that specifically targets the signal receptor CD47, responsible for activating the “Don’t Eat Me” biological message that cancer cells give to the immune system as they attempt to spread, grow and avoid destruction.

This work partially underpinned the platform for UHN start-up Trillium Therapeutics, created in 2004. In 2022, Pfizer Inc. acquired Trillium Therapeutics in a US$2.22 billion deal to further develop the TTI-621 asset, re-naming the drug to Maplirpacept. As of February 2025, Maplirpacept is undergoing global Phase II clinical trials for multiple hematological malignancies and remains competitive in the immunotherapy market. All of this was possible because of a discovery made decades ago by Drs. Jean Wang, John Dick and Jayne Danska at UHN’s Princess Margaret Cancer Centre & Sick Children’s Hospital.

Photo L to R: Dr. Brad Wouters (EVP, UHN Research), Dr. John Dick (Senior Scientist, PM), Dr. Jayne Danska (Senior Scientist, Sick Children’s Hospital Research Institute), Dr. Jean Wang (Senior Scientist, PM), Mark Taylor (Director, UHN Commercialization) and Kevin Smith (President & CEO, UHN)

Full story link in bio.
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Research at UHN, University Health Network, UHN Commercialization

08/10/2024

Princess Margaret Cancer Centre has been ranked #1 specialized hospital in Canada by World’s Best Specialized Hospitals 2025 for its expertise in oncology🎉

The list awards the leading hospitals around the world in 12 medical fields, and are ranked upon an overview of data collected from a worldwide online survey, accreditation scores, and Patient Reported Outcome Measures implementation surveys.

Congratulations to the team for all of your hard work and dedication in providing world-class care to patients 💙

https://www.newsweek.com/rankings/worlds-best-specialized-hospitals-2025/oncology

20/09/2024

This year marks the 40th anniversary of successfully cloning human T-cell receptor, a significant milestone in immunology and cancer therapy.

Join us in celebrating this breakthrough at T cell receptor symposium, featuring esteemed global immunologists, including Nobel Prize winner and more:

🧑‍🔬Dr. James Allison: 2018 Nobel Prize winner for Physiology and Medicine, whose findings established the field of immune checkpoint blockage therapy for cancer.

🧑‍🔬Dr. Tak Mak: 2023 winner of the International Award for Extraordinary Achievement in Cancer Research from the Pezcoller Foundation and the American Association for Cancer Research, known for his role in the cloning of the gene encoding the human T cell receptor beta chain in 1984, paving the way for existing immunotherapies, including CAR-T therapy and TCR-T therapy.

🧑‍🔬Dr. Michael Sadelain: 2024 winner of the Breakthrough Prize in Life Sciences and the Canada Gairdner International Award, for his contributions to the field of chimeric antigen receptors (CARs), from design to clinical translations.

Discover latest immunology trends in treating cancers and beyond at this one-day event. No RSVP needed.

Save the date: October 31, 2024
Location: Macleod Auditorium, University of Toronto.
Agenda: link in bio.

09/09/2024

How do we restore immunity against cancer?

🌟 Dr. David Brooks explores why our body’s immune system struggles to combat chronic diseases and cancer. At University Health Network, his team is also working to restore patients' immune responses to fight cancer more effectively.

“What I like (about research) is the potential to have the ability to do things that will ultimately impact people and patient care, and make the world a better place.”

Read more here: https://www.uhnresearch.ca/news/meet-dr-david-brooks-pmresearch

Research at UHN
The Princess Margaret Cancer Foundation

07/08/2024

Read this month's issue of UHN's Research Spotlight, a newsletter that highlights some of the top research advancements from Canada's largest research hospital >> https://www.uhnresearch.ca/newsletter/researchspotlight/researchspotlight_July2024.html

This month, read about
▶️ The role of human cardiac immune cells in heart development;
▶️ A novel classification system that changes the understanding of complications to radiation therapy;
▶️ A promising non-invasive technique to boost brain function and aid recovery; and
▶️ The link between concussion symptoms and visual stimulation.

To read previous issues, check out: https://www.uhnresearch.ca/newsletters

University Health Network
McEwen Stem Cell Institute
The Institute for Education Research at UHN
Krembil Brain Institute
Princess Margaret Cancer Centre Research
The KITE Research Institute

12/07/2024

Dr. Michael Glogauer, Chief of Dentistry and Department Head at the Princess Margaret Cancer Centre, has won the 2024 CADR/ACFD National Research Award for his game-changing work on neutrophils and oral health. His research is transforming our understanding of the oral-systemic health link.

READ MORE > https://www.uhnresearch.ca/news/innovative-oral-immunology-awarded

Congratulations to Dr. Glogauer on this well-deserved recognition!

University Health Network
Princess Margaret Cancer Centre Research
The Princess Margaret Cancer Foundation

10/06/2024

Congratulations to the Riders for a record year!

This past weekend, over 4,000 riders participated in the Ride To Conquer Cancer hosted by The Princess Margaret Cancer Foundation, biking 200km from Toronto to Niagara. The Ride set a fundraising record with $20.6M raised this year and more than $300M since its inception.

To read more:
https://www.newswire.ca/news-releases/ride-to-conquer-cancer-announces-surpassing-its-all-time-fundraising-total-and-raises-over-20-6-million-benefitting-the-princess-margaret-cancer-centre-804713405.html

To register for next year's event:
https://ride2conquer.ca/

10/06/2024

Breast Cancer Canada is excited to see PROgress Tracker being featured on the national stage at Canadian Association of Psychosocial Oncology (CAPO) conference in Calgary today.

Presented by Dr. Doris Howell from Princess Margaret Cancer Centre Research, today’s presentation discussed how a breast cancer diagnosis has a profound impact on a patient's emotional and physical well-being, as well as their overall quality of life.

Dr. Howell is a one of the Principal Investigators on Breast Cancer Canada’s national PROgress Tracker study. This registry aims to capture and amplify the voices of individuals living with breast cancer through their own reported experiences and outcomes. The ultimate goal is to use this data to improve breast cancer care for future Canadian patients. The information collected through this registry lifts up patient voices and is helping us understand the real-life experiences of those who are living with breast cancer.

We would like to extend our heartfelt thanks to the patients and survivors who have joined PROgress Tracker to date. Your participation is invaluable in helping us understand and improve the experiences of individuals with breast cancer.

For those who want to learn more or are interested in participating, please visit: PROgressTracker.ca

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