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Alpine Institute for Longevity Research and Diagnostics

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Alpine Institute for Longevity Research and Diagnostics

Non-profit research institute providing innovative diagnostics to combat aging and disease

26/11/2025

Researchers in Texas may have just unlocked a major piece of the longevity puzzle! 🧩

A new study has identified a molecule that restores levels of TERT (telomerase reverse transcriptase). Why does this matter? TERT helps maintain our telomeres, which naturally shorten as we age.

In tests with aged mice, restoring TERT levels led to some incredible results:

Reduced inflammation
New neuron formation
Improved memory
Enhanced muscle function

While we are still in the early stages, this suggests that targeting TERT could be a game-changer for fighting age-related brain and neuromuscular diseases in the future.

Read the full study here: https://doi.org/10.1016/j.cell.2024.05.048

09/11/2025

From petri dish to “mini-colons”
By merging organoid and organ-on-a-chip technologies, researchers have created advanced human gut models that more closely mirror real intestinal tissue — complete with mature colonocytes, mucus-producing goblet cells, and physiological cell turnover.
These mini-colons offer a long-lasting, diverse, and functional platform for studying gut physiology, modeling disease, and predicting drug-induced toxicities with greater precision.
It’s a big step forward for preclinical research and personalized medicine.

07/11/2025

Can diet help the aging brain bounce back?
New research shows that even a short-term ketogenic diet started later in life can sharpen working memory and boost synaptic plasticity in aged mice.
The key players? PKA signaling and BDNF, working together to restore brain function and vitality temporarily.
It’s compelling evidence showing how changes in nutrition shape cognitive health.

29/10/2025

Your blood tells a story about aging — and it’s written in expanding clones of cells.

As we age, certain groups of blood cells begin to dominate — a phenomenon called clonal hematopoiesis (CH). It’s linked to cancer risk and other aging-related health issues.
Until now, most research focused on a small set of well-known genes driving CH. But a large UK Biobank study of 200,000+ people just uncovered 17 more genes — including ZBTB33, SPRED2, CHEK2, and MYD88 — that expand with age and carry health risks.

These new “drivers” behave much like the classical ones:
They grow in frequency and size over time
They’re linked to higher infection risk, mortality, and blood cancers

The genetic landscape of CH — and its role in aging — is far broader than we thought.

09/10/2025

What if your DNA doesn’t just age in sequence… but in 3D space?

While we know genes can change with age, how they’re physically arranged in the cell’s nucleus — their 3D genome organization — may also play a major role.
A new study found that as immune cell progenitors in the bone marrow age, their chromatin (the physical arrangemnt of DNA in the nucleus) is reorganized on a large scale:

Interactions shift between compartments, while connections within certain regions weaken.
The gene Ebf1, crucial for B lymphocyte regulation, moves into a less active compartment with age — and lowering Ebf1 mimics features of older cells.
Regions important for B cell development, like the immunoglobulin heavy chain locus, show weaker internal connections, disrupting gene recombination.

These findings point to 3D chromatin reorganization as a key driver of immune cell aging — and possibly, immune function decline with age.

28/09/2025

Is aging following a set program… or is it more like a game of biological chance?

Three new studies are challenging the way we think about epigenetic aging — modifications that occur on our DNA over time.

Researchers looking at DNA methylation patterns in mice, immune cells, and large-scale simulations found that much of the aging signal may be stochastic — shaped by random changes — rather than strictly pre-programmed.

From single-cell analysis to aging clock simulations, the results suggest:
- A significant part of aging clocks’ accuracy can be explained by random, cumulative changes.
- Some clocks (like Zhang’s) may be up to 90% driven by stochastic processes.
- Others (like PhenoAge) still capture non-random, biological signals.

The big takeaway?
Aging might be less like a fixed script and more like an unpredictable story — with both random and coordinated elements shaping how we age.

24/09/2025

Can “young blood” show us the secrets to reversing aging?
Groundbreaking research reveals that small extracellular vesicles from young plasma can restore mitochondrial health, counteract senescence, and even extend lifespan in aged mice.
The key consists on stimulating PGC-1α to boost cellular energy metabolism.
It’s a big step toward understanding — and potentially harnessing — the biology of rejuvenation.

🔬 At Alpine Institute, we’re watching these discoveries closely as they reshape the future of longevity science.

08/09/2025

Nature holds the cures. AI is the key. 🌿

Enveda Biosciences is teaming up with Microsoft to supercharge drug discovery using AI + the cloud. Their new tool, PRISM, is a cutting-edge model trained on massive chemical datasets — think of it as a translator between nature’s molecules and modern medicine.

By harnessing Azure’s computational power, Enveda is decoding the chemical language of plants to uncover new, life-saving drugs faster than ever before.

Nature-inspired, AI-powered. This is the future of drug discovery.

➡️ Follow for more stories at the edge of science and tech.

06/09/2025

Is your diet aging you faster than your birth certificate says?

Chronological age (your birthday) doesn’t tell the whole story. Scientists now measure biological age (BA) — how “old” your body really is — based on things like metabolism, immunity, and organ function. The gap between BA and your actual age is called Age Acceleration (AgeAccel), and it matters a lot.

Here’s the twist: your diet could be pushing your biological age forward — or helping slow it down. A new study using UK Biobank data found links between dietary diversity and biological aging. People who ate a balanced mix of food groups had slower aging, fewer diseases, and longer lives.

🥗 Eat smarter. Age better.
✨ Want to stay younger, longer? Start with your plate.

➡️ Follow for more science-backed tips to hack your healthspan.

26/08/2025

Can an infection today influence your brain health decades from now?

A large population-based study in New Zealand suggests it might.
Researchers found that people who had certain infections were more likely to be diagnosed with dementia — even 25–30 years later. The associations showed up across multiple infection types and dementia forms, including Alzheimer’s and vascular dementia.

It’s an impressive longitudinal study that tooks decades in the making — but it’s still correlation-based, and there are questions about whether the data were presented in the most statistically robust way.

This finding sparks an important conversation: How do we balance early warnings from research with the caution needed before drawing causal conclusions?

23/08/2025

What if the secret to healthy aging lies in the very cells we once thought were just… “retired”?

Around the world, people are living longer — but are we living healthier?
One key player in the story of aging is cellular senescence — when cells stop dividing. For years, it was seen as a problem to fix. But science is uncovering a twist: these so-called “senescent” cells can also be protectors, helping with wound healing, tumor suppression, and tissue repair.
The big challenge? Figuring out when they’re friends, when they’re foes — and how to target them without harming their beneficial roles.

At Alpine Institute, we’re diving deep into these questions to help shape strategies for longer, healthier lives.

12/08/2025

What if you could measure the age of your brain—and train it to feel younger?

That’s the bold vision behind a new partnership between Sens.ai .ai.inc and the Buck Institute for Research on Aging. Together, they’re working to develop a biological clock for the brain, combining neurotechnology, AI, and advanced biomarker tracking.

Led by Sens.ai CEO Paola Telfer and renowned aging expert Dr. Eric Verdin, the project aims to measure—and eventually reverse—brain aging using real-time data and personalized brain training interventions.

This is the next frontier in cognitive longevity.

Follow us to stay at the forefront of brain health, aging science, and neurotech breakthroughs.
🧬 Would you test your brain’s biological age?

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