20/11/2019
9 Potential Health Benefits of Radix Scutellaria Extract
Radix Scutellariae Extract (RSE)
Radix Scutellariae Extract (RSE),also called chinese skullcap and Baikal skullcap, is an extract from the dried root of Scutellariae baicalensis Georgi(I.E. the mint family and Scutellarioideae subfamily), is extensively employed in traditional Chinese medicines and modern herbal prescriptions.
What Are Baicalein and Baicalin?
The root of Chinese skullcap contains six flavones and have been reported to be the major bioactive components, namely, baicalein,baicalin,wogonin, oroxylin A, wogonoside, and oroxylin A-7-O-glucuronide. Baicalin is the most abundant flavonoid constituent of the root of Scutellaria baicalensis and Scutellaria lateriflora.
What Are Potential Healthy Benefits of Radix Scutellariae Extract (RSE)?
Chinese skullcap ( Scutellaria baicalensis ) is officially listed in Chinese Pharmacopoeia with various pharmacological effects including anti-inflammation, antioxidation, neuro-protection, and immunomodulation[25–28].
What is RSE(Baicalin,Baicalein) Used for Today?
RSE in highly preliminary evidence suggests that baicalin, wogonin, and baicalein may have antiosteoporosis[29-30], anti-cancer[31,7-12], Liver Protection[32] , anti-anxiety[1-2] , and anti-neuroprotective effects[3-6] . Meanwhile, RSE is also recognized well as a natural ingredient in cosmetic products, RSE may be applied to the skin (e.g., eye shadows,lipstick,bath soaps and detergents).
Basically there are 9 potential healthy benefits of RSE,as below
1)Antiosteoporosis
Baicalin and baicalein, both flavonoids, used as a component of nutriceuticals for osteoporosis prevention or bone implants in Traditional Chinese Medicine(TCM) is proved[33].
2) Anti-Anxiety
RSE inhibit the action potential of the neurons that raise anxiety [1].
In mice, baicalin produces anxiety-lowering effects without causing drowsiness or muscle relaxation [2].
3) Anti-Neuroprotective
Baicalin improved cognitive dysfunction in mice via its anti-neuroinflammatory activity and may be a potential candidate for the treatment of Alzheimer’s Disease (AD) [3].
It improved Amyloid beta-induced learning and memory deficit, hippocampus injury and neuron apoptosis (mice) [4].
Baicalin improves learning and memory impairment induced by brain injury in mammals [5].
Treatment with this flavonoid in animals, post-stroke, promotes neuron development in damaged sections of the brain, including the new formation of cells in the hippocampus [6].
4) Anti-Cancer
Short-term treatment (48 hours) with baicalein inhibits the proliferation of human ovarian cancer cells. An increase in cell death was observed when combined with Taxol (a chemotherapy drug) [7].
Baicalein suppressed proliferation, migration, and invasion of breast cancer cells in a time and dose-dependent manner. It had the potential to suppress breast cancer metastasis [8].
Baicalein, when ingested, is metabolized and inhibits the proliferation of human colorectal cancer cells [9].
It destroys the S cycle of colorectal cancer cells, which promotes cell death and prevents further replication [10].
Baicalin ingested at a dose of 100 mg/kg for 28 days decreases tumor growth and replication in mice with colon cancer cells [11].
When taken orally in rats for 7 days it increases the activity of T helper cells and T regulatory cells to fight chemically-induced colon cancer [12].
5) Skincare
RSE is also recognized well as a natural ingredient in cosmetic products[24], its major bioactive ingredient baicalin is applied as a topical cream protects the skin with antioxidant effects. It also reduces UV-related apoptosis (cell death) [13, 14].
6) Liver Protection
Baicalin administered in rats reduced the effects of fatty liver disease (by increasing PPAR gamma and insulin receptors) [15].
It decreases cholesterol, alanine transaminase, low-density lipoproteins, and TNF levels.
Rats with alcohol-induced liver damage treated with this flavonoid before consuming alcohol had protective effects on the liver. It also decreased liver cell apoptosis [16].
7) Lung Function
Pure baicalin is successful at improving lung function in rats which suffer from allergic diseases [17].
When administered to rats suffering from asthma as a pretreatment, showed a healthy remodeling of the airway [18].
Baicalein reduces lung inflammation by inhibiting Th17 cells in the lungs [19].
8) Eyes
Daily intake of baicalin or baicalein helps prevent eye diseases such as cataracts or age-related macular degeneration in animals [20].
Baicalin is found in traditional Japanese herbal medicines for eye health [21].
9) Fertility
In animals, baicalin significantly enhances endometrial reproduction [22].
In mice embryos, it increases the development and quality of blastocysts [23].
Where to buy Radix Scutellariae Extract (RSE)?
MuziAgri, a chinese company specializing in the cultivation, production, research and development, sales and export of Chinese herbal medicines and herbal extraxts, is one of the leading manufacturer of RSE, has more than 500tons of annually production capacity of RSE, and MuziAgri featured products (Organic Radix Scutellaria extract, Organic chinese peony flower extract, Organic Black Goji Berry Extract, Usnic acid ) are widely used and well recognized in the fields of pharmaceuticals, cosmetics and healthy foods, functional beverage, daily chemicals etc. ,
"You deserve stableprofessional qualified products and superior service"!
Contact us for more details of MuziIAgri and products:
Lily Lei(Ms.)
International Marketing Dept. of Muzi Agricultural Ltd
E_mail:lily@mz-farm.com
Web:www.mz-farm.com
(Noted: some aspects of this article are quoted from"7 Potential Health Benefits of Baicalin and Baicalein" that writen by Joe Cohen, BS | Reviewed by Genius Labs Science Team )
References：
1. GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin https://doi.org/10.1016/j.neuropharm.2008.07.040
2.Planta Med 2000; 66(1): 91-93 DOI: 10.1055/s-0029-1243121
3. Baicalin attenuates alzheimer-like pathological changes and memory deficits induced by amyloid β1-42 protein. PMID: 25108596 DOI:10.1007/s11011-014-9601-9 https://www.ncbi.nlm.nih.gov/pubmed/25108596
4. Protective Effects of Baicalin on Aβ₁₋₄₂-Induced Learning and Memory Deficit, Oxidative Stress, and Apoptosis in Rat. PMID:25596671 DOI:10.1007/s10571-015-0156-z https://www.ncbi.nlm.nih.gov/pubmed/25596671
5. Baicalin alleviates ischemia-induced memory impairment by inhibiting the phosphorylation of CaMKII in hippocampus. , PMID: 27016057 DOI: 10.1016/j.brainres.2016.03.019 , https://www.ncbi.nlm.nih.gov/pubmed/27016057
6. Baicalin regulates neuronal fate decision in neural stem/progenitor cells and stimulates hippocampal neurogenesis in adult rats. PMID: 23302221 PMCID: PMC6493621 DOI: 10.1111/cns.12050 https://www.ncbi.nlm.nih.gov/pubmed/23302221
7. A Combination Therapy with Baicalein and Taxol Promotes Mitochondria-Mediated Cell Apoptosis: Involving in Akt/β-Catenin Signaling Pathway. PMID: 27414207 DOI: 10.1089/dna.2016.3312 https://www.ncbi.nlm.nih.gov/pubmed/27414207
8. Colon cancer chemopreventive effects of baicalein, an active enteric microbiome metabolite from baicalin. PMID: 26398706 PMCID: PMC4599184 DOI: 10.3892/ijo.2015.3173 https://www.ncbi.nlm.nih.gov/pubmed/26398706
9. Colon cancer chemopreventive effects of baicalein, an active enteric microbiome metabolite from baicalin. PMID: 26398706 PMCID: PMC4599184 DOI: 10.3892/ijo.2015.3173 https://www.ncbi.nlm.nih.gov/pubmed/26398706
10. Pretreatment of baicalin and wogonoside with glycoside hydrolase: a promising approach to enhance anticancer potential PMID: 24026776 PMCID: PMC3820585 DOI: 10.3892/or.2013.2726 https://www.ncbi.nlm.nih.gov/pubmed/24026776
11. [Effects of Baicalin on an orthotopic transplantation mouse model of mismatch repair gene deficient colorectal cancer] PMID: 23157964 https://www.ncbi.nlm.nih.gov/pubmed/23157964
12. Baicalin attenuates TNBS-induced colitis in rats by modulating the Th17/Treg paradigm. PMID: 25269538 DOI: 10.1007/s12272-014-0486-2 https://www.ncbi.nlm.nih.gov/pubmed/25269538
13. Baicalin scavenges reactive oxygen species and protects human keratinocytes against UVC-induced cytotoxicity. PMID: 24292572 https://www.ncbi.nlm.nih.gov/pubmed/24292572
14. Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals. PMID: 26783703 PMCID: PMC4665475 DOI: 10.3390/antiox4020248 https://www.ncbi.nlm.nih.gov/pubmed/26783703
15. Effects of a combination of puerarin, baicalin and berberine on the expression of proliferator-activated receptor-γ and insulin receptor in a rat model of nonalcoholic fatty liver disease. PMID: 26889237 PMCID: PMC4726904 DOI: 10.3892/etm.2015.2846 https://www.ncbi.nlm.nih.gov/pubmed/26889237
16. Scutellaria baicalensis Georgi extract protects against alcohol‑induced acute liver injury in mice and affects the mechanism of ER stress. PMID: 26936686 PMCID: PMC4805105 DOI: 10.3892/mmr.2016.4941 https://www.ncbi.nlm.nih.gov/pubmed/26936686
17. Comparative pharmacokinetics of a marker compound, baicalin in KOB extract after oral administration to normal and allergic-induced rats. PMID: 24447164 DOI: 10.3109/10717544.2013.876561 https://www.ncbi.nlm.nih.gov/pubmed/24447164
18. Baicalin inhibits PDGF-induced proliferation and migration of airway smooth muscle cells. PMID: 26884970 PMCID: PMC4723815 https://www.ncbi.nlm.nih.gov/pubmed/26884970
19. Baicalin Alleviates Silica-Induced Lung Inflammation and Fibrosis by Inhibiting the Th17 Response in C57BL/6 Mice. PMID: 26605988 DOI: 10.1021/acs.jnatprod.5b00868 https://www.ncbi.nlm.nih.gov/pubmed/26605988
20. Potential therapeutic effects of baicalein, baicalin, and wogonin in ocular disorders. PMID: 25280175 DOI: 10.1089/jop.2014.0074 https://www.ncbi.nlm.nih.gov/pubmed/25280175
21. Traditional Japanese herbal (kampo) medicines and treatment of ocular diseases: a review. PMID: 22928823 DOI: 10.1142/S0192415X12500668 https://www.ncbi.nlm.nih.gov/pubmed/22928823
22. Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta-catenin signaling pathway. PMID: 25896022 DOI: 10.1016/j.febslet.2015.04.011 https://www.ncbi.nlm.nih.gov/pubmed/25896022
23. Baicalin increases developmental competence of mouse embryos in vitro by inhibiting cellular apoptosis and modulating HSP70 and DNMT expression. PMID: 27478062 PMCID: PMC5177973 DOI: 10.1262/jrd.2016-047 https://www.ncbi.nlm.nih.gov/pubmed/27478062
24. Safety Assessment of Scutellaria baicalensis-Derived Ingredients as Used in Cosmetics, Status: Scientific Literature Review for Public Comment Release Date: June 20, 2019 Panel Date: September 16-17, 2019https://www.cir-safety.org/sites/default/files/scutel092019slr.pdf
25. Yoon S-B, Lee Y-J, Park SK, et al. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. Journal of Ethnopharmacology. 2009;125(2):286–290. [PubMed] [Google Scholar]
26. Shao Z-H, Li C-Q, Vanden Hoek TL, et al. Extract from Scutellaria baicalensis Georgi attenuates oxidant stress in cardiomyocytes. Journal of Molecular and Cellular Cardiology. 1999;31(10):1885–1895. [PubMed] [Google Scholar]
27. Choi J, Conrad CC, Malakowsky CA, Talent JM, Yuan C-S, Gracy RW. Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines. Biochimica et Biophysica Acta. 2002;1571(3):201–210. [PubMed] [Google Scholar]
28. Li C-Y, Hou Y-C, Lee Chao P-D, Shia C-S, Hsu IC, Fang S-H. Potential ex vivo immunomodulatory effects of San-Huang-Xie-Xin-Tang and its component herbs on mice and humans. Journal of Ethnopharmacology. 2010;127(2):292–298. [PubMed] [Google Scholar]
29. Guo AJY, Choi RCY, Cheung AWH, et al. Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/β-catenin signaling pathway. Journal of Biological Chemistry. 2011;286:27882–27893. [PMC free article] [PubMed] [Google Scholar]
30. Kim MH, Ryu SY, Bae MA, Choi J-S, Min YK, Kim SH. Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis. Food and Chemical Toxicology. 2008;46(11):3375–3382. [PubMed] [Google Scholar]
31.Ying Gao,Shane A. Snyder,Jaclyn N. Smith,Yi Charlie Chen, Anticancer properties of baicalein: a review, Medicinal Chemistry Research August 2016, Volume 25, Issue 8, pp 1515–1523 https://link.springer.com/article/10.1007%2Fs00044-016-1607-x
32.YiYanZhaoYongLiChunyingZhangYushiBinYangYuanYalanPanChenWangLianmeiLiangAihua Potential chronic liver toxicity in rats orally administered an ethanol extract of Huangqin (Radix Scutellariae Baicalensis) https://www.sciencedirect.com/science/article/pii/S025462721830267X
33.Guo AJY, Choi RCY, Cheung AWH, et al. Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/β-catenin signaling pathway. Journal of Biological Chemistry. 2011;286:27882–27893. [PMC free article] [PubMed] [Google Scholar] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151034/
Muzi Agricultural supplies superior natural ingredients for pharmaceuticals,nutriceuticals,cosmetics,healthy foods and beverage industries.
