01/12/2025
When magnesium runs low, hormones stop listening
Most people think of magnesium for sleep or stress, but it actually supports almost every hormone system in the body. And here’s something many patients don’t realize: your magnesium lab can look “normal” even when your cells are running on empty.
Here’s how low magnesium affects your hormones:
(1) Cortisol & Stress Regulation
Magnesium helps regulate the HPA axis; it keeps your stress signals from staying “on” all day. Chronic stress drains magnesium quickly; low magnesium then pushes cortisol even higher → more inflammation; more hormonal imbalance.
(2) Estrogen Detox & PMS
Magnesium activates COMT, the pathway that clears used estrogen through the liver. When COMT slows, estrogen lingers → PMS; breast tenderness; irritability; mood swings; heavier cycles.
(3) Thyroid Function
Magnesium supports the conversion of T4 to active T3. Low tissue magnesium can feel like slow metabolism; fatigue; brain fog.
(4) Insulin Sensitivity
Your cells need magnesium to respond properly to insulin. Low levels can worsen resistance; increase inflammation; make weight loss more difficult.
(5) Sleep & Nighttime Hormone Reset
Magnesium supports GABA and melatonin. Without enough of it, your body struggles to reach deep, restorative sleep where hormones recalibrate.
Why your “normal” magnesium lab might not tell the full story
Only about 1 percent of magnesium is in the blood. Most of it is inside tissues where hormones actually depend on it. Serum magnesium can appear fine even when tissue levels are low.
Better assessments include RBC magnesium; symptom patterns; and evaluating stress load and nutrient demand.
If you’re dealing with PMS; stubborn weight; sleep issues; or stress-related burnout, magnesium might be a missing piece. Functional medicine helps identify where the imbalance starts and how to restore optimal hormone signaling.
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