International CML Foundation

International CML Foundation Improving outcomes for patients with CML globally. The International CML Foundation (iCMLf) is on a mission to improve outcomes for patients with CML, globally.

Founded by a dedicated group of hematologists, we are committed to ensuring every patient with CML, no matter where they are in the world, receives the best possible care. We foster international collaboration to elevate knowledge, enhance diagnostics, and drive ground-breaking research. As a charitable foundation with a global reach, we strive to empower physicians, researchers, patients and caregivers alike, in the collective pursuit of a cure. Join us and contribute to a world where a cure for CML is not just a hope, but a reality.

Happening Today! It's not too late to join us.Join the next iCMLf Regional Discussion Group Meeting for Africa - an inte...
12/11/2025

Happening Today! It's not too late to join us.

Join the next iCMLf Regional Discussion Group Meeting for Africa - an interactive session bringing together CML experts and physicians from across the region.

🩺 Topics:
• CML and pregnancy in resource-constrained settings
• Overcoming challenges in adherence to therapy

🕔 Today – November 12th

Online | Open to all physicians treating CML in Africa
French interpretation available

Join here: https://buff.ly/uROAtbK

11/11/2025

🎥 Highlights from the ESH-iCMLf 27th Annual John Goldman Conference on CML: Biology and Therapy

Thank you to everyone who joined us in Estoril for this year’s conference - three days of connection, collaboration, and cutting-edge science in CML.

From world-leading research presentations to inspiring prize lectures and early morning Fun Run moments, the meeting celebrated innovation and community across the global CML field.

See you next year!

iCMLf Papers of the Month – September & OctoberOur regular Paper of the Month feature took a short pause during the busy...
10/11/2025

iCMLf Papers of the Month – September & October

Our regular Paper of the Month feature took a short pause during the busy period of the ESH–iCMLf 27th Annual John Goldman Conference on CML: Biology and Therapy, but we’re now back with a collection of papers selected by Professor Tim Hughes.

Highlights include:

1️⃣ Impact of ASXL1 at diagnosis in patients with chronic myeloid leukemia receiving frontline potent tyrosine kinase inhibitors: high risk of kinase domain mutations
Shanmunagathan N et al. Blood, September 2025 (epub ahead of print)
https://buff.ly/SHn2fxz

2️⃣ A newcomer in allosteric therapy for Ph+ leukemias
Delphine Rea. Blood, October 2025 – open access publication
https://buff.ly/zPHmXpV

3️⃣ Uncommon phenotypes of BCR::ABL1-positive chronic myelogenous leukemia
Jajosky AN et al. Haematologica, September 2025 – open access publication
https://buff.ly/VNMzl11

4️⃣ Revisiting treatment-free remission: A case of late molecular recurrence in chronic myeloid leukemia
Sharma V et al. J Assoc Physicians India, September 2025
– open access publication
https://buff.ly/NNWFPpi

📖 Explore the full list of papers on our website:
https://buff.ly/9DoiXTp

CML Physicians in Africa – One Week to Go!The final 2025 iCMLf Regional Discussion Group Meeting for Africa takes place ...
05/11/2025

CML Physicians in Africa – One Week to Go!

The final 2025 iCMLf Regional Discussion Group Meeting for Africa takes place next Wednesday, November 12th. Join CML experts and colleagues from across Africa to explore key challenges in treatment and patient care.

Topics:
• CML and pregnancy in resource-constrained settings
• Overcoming challenges in adherence to therapy

🗓 Date: November 12th
Online | Open to all physicians treating CML in Africa
French interpretation available

⏰ Start times:
Accra/Dakar – 17:00 | Rabat/Abuja – 18:00 | Khartoum/Beira – 19:00 | Addis Ababa/Moshi/Nairobi – 20:00

🔗 Register now: https://us02web.zoom.us/meeting/register/M5btYKFERF28Id7J9_MKWg #/registration

05/11/2025

📣 STARTS THIS FRIDAY!
DON’T MISS THE OPPORTUNITY, REGISTER NOW ➡ bit.ly/3ZQWwEa
ESH- 27th Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy
🎓Chairs: Jorge Eduardo Cortes, MD Timothy Hughes, Daniela Krause


International CML Foundation Sociedade Portuguesa de Hematologia British Society for Haematology

iCMLf Abstract Selected for Oral Presentation at ASH 2025We’re delighted to share that the first analysis from the iCMLf...
04/11/2025

iCMLf Abstract Selected for Oral Presentation at ASH 2025

We’re delighted to share that the first analysis from the iCMLf/HARMONY Foundation CML Genomics Project will be presented at the ASH Annual Meeting 2025.

Professor Susan Branford will present:
Somatic mutations at diagnosis in patients with chronic phase CML receiving frontline imatinib are associated with a higher rate of treatment failure: First analysis from the International CML Foundation (iCMLf) Genomics Alliance on the HARMONY platform.

🗓 Saturday, December 6th, 9:30am (Orlando time)
📍 Oral Abstract Session: Chronic Myeloid Leukemia – Clinical and Epidemiological

Based on data from 468 patients, the study shows that somatic mutations—particularly ASXL1—may influence treatment outcomes, offering new insights for future risk stratification and CML management.

Congratulations to Professor Branford and all collaborators involved in this milestone work from the iCMLf/HARMONY CML Genomics Project.

Couldn’t make it to Estoril? We’ve got you covered.From cutting-edge science to global collaboration - the ESH-iCMLf 27t...
04/11/2025

Couldn’t make it to Estoril? We’ve got you covered.

From cutting-edge science to global collaboration - the ESH-iCMLf 27th Annual John Goldman Conference on CML: Biology and Therapy was packed with insights shaping the future of CML care.

You can now read the full scientific session summaries and catch up on the breakthroughs, debates, and key discussions that defined this year’s meeting.

👉 https://buff.ly/Cw2TAlL

🏃What a morning to remember!Thank you to everyone who joined the 2025 John Goldman Fun Run during the ESH-iCMLf 27th Ann...
30/10/2025

🏃What a morning to remember!

Thank you to everyone who joined the 2025 John Goldman Fun Run during the ESH-iCMLf 27th Annual John Goldman Conference on CML: Biology and Therapy in Estoril.

More than 50 participants set off before sunrise for a 5-km seaside run—dressed in bright purple shirts, full of energy, laughter, and camaraderie. Together, we raised US $2,900 - our highest total yet! 🎉

Every step, every smile, and every donation supports the iCMLf’s mission to improve access to CML education and care in low- and middle-income countries, helping physicians and patients where it’s needed most.

A heartfelt thank you to everyone who ran, walked, cheered, and donated. Your support makes a real difference.

💜 Missed the run? It’s not too late to contribute: https://the-international-cml-foundation.raiselysite.com/

Have you read the iCMLf 2024–25 Annual Report?It’s more than a summary, it’s a reflection of what we’ve achieved togethe...
29/10/2025

Have you read the iCMLf 2024–25 Annual Report?

It’s more than a summary, it’s a reflection of what we’ve achieved together.

From expanding access to CML expertise through our global programs, to celebrating 25 years of TKIs, it’s been a milestone year for the Foundation. You’ll also find:

✅ Highlights from the ESH-iCMLf John Goldman Conference
✅ Key stats and global reach of our Regional Discussion Groups
✅ Updates on our resources, alliances, and research support
✅ A special timeline marking 25 years of TKI therapy
✅ Recognition of our supporters and partners who make this work possible

Catch up on everything we’ve accomplished, and what’s ahead.
📖 Read the report here: https://heyzine.com/flip-book/593635acd4.html

Thank you to everyone who joined our recent Regional Discussion Group for Africa. If you weren’t able to attend, or want...
24/10/2025

Thank you to everyone who joined our recent Regional Discussion Group for Africa. If you weren’t able to attend, or want to revisit the insights, you can now watch the full session online.

Topics covered:
- Attempting TFR in resource-constrained settings
- Experience with TKI generics in resource-constrained settings

Available in both English and French.

👉 Watch the recordings here: https://buff.ly/yZdJdJ1

🗓️ Happening today!It's not too late to join us for the iCMLf Conversation at 14:00 CEST - featuring Professors Jorge Co...
22/10/2025

🗓️ Happening today!

It's not too late to join us for the iCMLf Conversation at 14:00 CEST - featuring Professors Jorge Cortes and Daniela Krause sharing highlights from the ESH-iCMLf 27th Annual John Goldman Conference on Chronic Myeloid Leukemia: Biology and Therapy.

Don’t miss this expert overview of the latest research, clinical data, and emerging trends in CML care.

💻 Live on Zoom
⏰ 14:00–14:45 CEST
🔗 Register now to join: https://buff.ly/AuKw5i6

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