Dr Catharine Denning

Dr Catharine Denning Marylebone Skin is a Dr led Aesthetics clinic based in London & Heathfield

Thank you for recommending me in for natural looking lip filler results 👄 it’s an honour to be recommended by someone ...
17/11/2025

Thank you for recommending me in for natural looking lip filler results 👄 it’s an honour to be recommended by someone so knowledgeable and prominent in the aesthetics industry 🙏

04/11/2025

An interesting new paper has just been published in Toxcon by et al— using AI modeling to explore the relationship between GLP-1 agonists and the duration of neuromodulators.

The model, which simulated over 25,000 cases, found that all GLP-1 agonists reduced the duration of Botulinum-A effect — regardless of whether it was used for aesthetic or medical purposes.
In chronic migraine, the effect dropped from around 14 weeks to about 12, and in masseter treatments, from about 20 weeks down to 16 or 17.

Interestingly, the degree of reduction varied by drug — with semaglutide showing the least impact and tirzepatide the most. Mechanistically, this was linked to GLP-1–induced changes in SNAP-25 phosphorylation and lean mass reduction.

I found this fascinating because it’s something I’ve been noticing in clinic — and many colleagues have mentioned the same.

Now, it’s really important to note — these results are exploratory and come entirely from computational modeling, not clinical trials.
This approach is common in early-stage research — it’s cost-effective, avoids animal studies, and helps identify what human studies might be most valuable next.

So while this doesn’t change clinical practice yet, it does highlight a potential drug–procedure interaction we should keep an eye on — and maybe rethink how we dose and schedule treatments for patients on GLP-1s

Relfydess is a game changer in the anti-wrinkle injectable space. Fastest onset, longest duration and the most precise d...
30/10/2025

Relfydess is a game changer in the anti-wrinkle injectable space. Fastest onset, longest duration and the most precise dosing on the market. Thank you for featuring my thoughts alongside my work husband (is it even a feature if we aren’t named together these days😂?). It’s always a huge honour to be featured in

💉Medicated driven weight loss (MDWL) is probably one of the most talked about medical interaction of the past decade. 💉H...
30/10/2025

💉Medicated driven weight loss (MDWL) is probably one of the most talked about medical interaction of the past decade.
💉Here I talk about MDWL, its potential effects on facial aging and what can be done to avoid negative effects on the facial structure and especially the skin.
💉Leave your comments below, this one is such an area of interest for a lot of people 👇

💉Medicated driven weight loss (MDWL) is probably one of the most talked about medical interaction of the past decade. 💉H...
30/10/2025

💉Medicated driven weight loss (MDWL) is probably one of the most talked about medical interaction of the past decade.
💉Here I talk about MDWL, its potential effects on facial aging and what can be done to avoid negative effects on the facial structure and especially the skin.
💉Leave your comments below, this one is such an area of interest for a lot of people 👇

✨This transformation is why I adore what I do✨This wonderful patient came in today for me to review the results of the l...
25/09/2025

✨This transformation is why I adore what I do✨
This wonderful patient came in today for me to review the results of the last 6 months of treatment and has kindly allowed me to share her images and her story with you for educational purposes.
✨She is in her late 60s and in recent years has had some significant health issues resulting in admission to ITU and significant rapid weight loss (her weight has remained unchanged since).
✨She is a high energy, hard working business owner who still works 7 days a week and travels the world with her business. She came to me because her son is getting married and she said she looked older on the outside than she felt on the inside. This is what we did for her:
🧴Skincare Obagi CRX system to help with pigmentation and general skin health
💉Sculptra 3 vials split over 3 sessions for natural revolumising and increased collagen, elastin and adipose.
⚡️1 session BBL heroic Moxi laser
Thank you so much to my wonderful patient for allowing me to share these images! So delighted that you’re so happy with your results 🙏

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What red and green flags to look for when sourcing aesthetics training. This industry is like the Wild West and that inc...
17/09/2025

What red and green flags to look for when sourcing aesthetics training. This industry is like the Wild West and that includes huge variability in training quality and cost.
Thank you for featuring my advice in this months journal

Thank you for featuring my advice on summer skincare. Three take away points:There’s no need to stop using actives Mai...
18/07/2025

Thank you for featuring my advice on summer skincare. Three take away points:
There’s no need to stop using actives
Maintain a healthy barrier function using ceramides (I like range as they cater for all skin types)
Sun protection is non-negotiable (especially if you are continuing your actives in sunny weather)

Address

Light Centre, 49 Marylebone High Street
London
W1U5HJ

Opening Hours

Tuesday 9am - 5pm
Wednesday 9am - 5pm
Thursday 9am - 5pm
Friday 9am - 5pm

Telephone

+442071268305

Website

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