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Emanuele’s osteopathic approach sees pain as a complex blend of physical, psychological, and social factors. He is also UK leader in Oxygen-Ozone therapy.

He crafts personalized treatment plans, earning trust from CEOs, royals, and elite athletes.

01/12/2025

Cognitive performance isn’t just about the brain.
It’s about the body the brain is sitting in.

If you look at people in mentally demanding jobs — founders, analysts, clinicians, traders, executives — the pattern is becoming impossible to ignore:

They’re not underperforming because they lack skill.
They’re underperforming because their physiology is saturated.

And the research backs this brutally clearly.

A large multicentre study on >9,000 adults showed that when chronic stress builds up, two things rise together:
• Extracellular water (ECW) — a marker of inflammatory fluid shift
• Drops in HRV — SDNN and RMSSD plummet as autonomic resilience collapses

This isn’t “just stress.”
It’s measurable degradation of the neuro-endocrine-metabolic axis — the same axis that governs focus, decision-making, emotional regulation, and executive function.

Another study demonstrated that increased ECW is not a benign finding. Inflammation and stress shift water from inside the cell to the extracellular space, impairing cellular efficiency and slowing tissue recovery.

And that matters for cognition.

When intracellular water drops, the nervous system becomes electrically rigid. HRV falls. The matrix becomes congested. Mental clarity narrows. Reaction time slows. Fatigue sharpens.
This isn’t psychology — it’s physics.

Even in children and young adults, the same pattern is visible:
• Higher inflammation → higher fat mass
• Higher cortisol → altered HRV
• Both combined → measurable behavioural and cognitive differences

So what does this mean for high-pressure professionals?

Most “cognitive problems” aren’t brain problems.
They’re system problems:

– Under-recovery
– Chronic sympathetic drive
– Flattened HPA axis
– Matrix congestion
– Loss of cellular hydration
– Subclinical inflammation

When these drift, you can have the sharpest mind in the world — but it’s running on a degraded operating system.

For years, only elite performers — F1, MotoGP, Olympic staff — had access to systems that actually measured and corrected these patterns.

That’s changing.

I’ve been working on something that makes these physiological blind spots visible and correctable — in minutes, not months.

I’ll share more soon.

For now:
If you rely on your mind to make high-stakes decisions, start thinking beyond sleep apps and supplements.

Your cognitive output is only as good as the physiological system generating it.

The data is clear.
Most people aren’t “burnt out.”
They’re overloaded — and no one has ever measured it properly.

Something new is coming that will.

---

Chrousos G.P. et al. (2022). PPG-HRV & ECW in chronic stress and inflammation. Hormones.
Straub R.H. et al. (2016). Extracellular water & volume overload in RA. Clinical Rheumatology.
Christaki E.V. et al. (2022). Stress, inflammation & body composition in youth. Children.
Stefanaki C. et al. (2016). Early osteosarcopenic features in young adults. Eur. Clin. Invest.

28/11/2025

When the Real Problem Isn’t “Inflammation”… It’s Water You Can’t See

Three months ago, a 44-year-old woman came to my clinic exhausted, swollen, and frustrated.
She had “mild rheumatoid arthritis,” normal-ish bloods, no joint destruction, no flare — yet she kept feeling heavier, puffier, and constantly fatigued.

Her GP kept saying: “Your markers aren’t that high — it’s just stress.”
She felt dismissed. And she was right.

Her issue wasn’t classic inflammation.
It was volume overload — a chronic shift of water from inside her cells into the extracellular space.

A major study showed that treatment-naïve RA patients had much higher extracellular water than healthy controls (49.5% vs 36.7% of total body water), a sign of deeper physiological overload driven by stress-activated pathways .

Back to my patient.

Her bioimpedance test revealed:
• Extra cellular water very high
• Intra cellular water low
• Phase angle low
• Early extra cellular matrix congestion

Exactly the pattern described in the research.

She wasn’t inflamed — she was congested, metabolically and electrically.

So we shifted the strategy:
• Circadian hydration and nutrition
• Lower acid load
• Vagal-based recovery work
• Albumin + intracellular hydration support
• Targeting matrix inflammation, not joints

Six weeks later, her swelling dropped, her energy returned, and the brain fog lifted — without altering her RA medication.

The bottleneck wasn’t the disease.
It was the underlying physiology.

Something Important Is Coming…

We’re now only days away from launching something built exactly for cases like this — a system that identifies these patterns early and treats them properly, long before they turn into disease.

I can’t name it yet.
But you’ll hear about it very soon.

Stay close.

24/11/2025

Tendinopathies drag on for months, sometimes years — and the usual pathway is always the same:

Rest.
Physio.
Braces.
Shockwave.
NSAIDs.
Steroid injections… one, then another.

And still the pain persists.

A patient walked into my clinic with a 3-year lateral epicondylitis (tennis elbow).
He had done everything.
Two corticosteroid injections gave him temporary relief and then made things worse — which, as the literature shows, is not surprising. Steroids can weaken tendon structure and increase recurrence.

He asked me a simple question:
“What else is left?”

We started a structured plan using oxygen–ozone therapy, twice a week.

After 5 sessions, he was pain-free.
Today he’s back on the tennis court — and playing better than before the injury.

No drugs.
No downtime.
Just a direct biological intervention that restores tissue function rather than suppressing it.

Why ozone works for tendinopathies

Ozone isn’t magic. It’s biochemistry.

Oxygen–ozone therapy creates a controlled, local oxidative stimulus that the body responds to by activating:
• Fibroblast proliferation (the cells that rebuild tendon matrix)
• Growth factor release (PDGF, TGF-β, VEGF)
• Improved microcirculation
• Reduced chronic inflammation
• Enhanced antioxidant response

Chronic tendinopathy isn’t an “inflammation problem” — it’s a degenerative matrix problem.
Ozone addresses exactly that.

It pushes the tissue from stagnant and catabolic to repair-driven and anabolic.

And unlike steroids, it doesn’t weaken the tendon. It strengthens it.

Stefanaki et al., Hormones 2018 — chronic stress & tissue degeneration mechanisms.

Ozone improves extracellular matrix dynamics
Bioimpedance-based studies show the role of inflammation-driven matrix expansion in musculoskeletal symptoms — the same process ozone down-regulates.
Straub et al., Clinical Rheumatology — inflammation, ECW increase & matrix congestion.

If you want a treatment that doesn’t just numb symptoms but actually targets the biology of the injury, ozone deserves a place at the table.

11/11/2025

🧬 The day I said no to a methylation test.

A patient came to see me recently, holding a detailed methylation report.
Pages of data, complex pathways, colourful charts.
He looked at me and said:
“Can you tell me which supplements I should take from this?”

I smiled and said, “Let’s make a deal.”

I told him: I won’t review your methylation test — not yet.
Wait until we complete all the analyses I’m about to do.
Wait until we interpret your body’s data — how your cells hydrate, how your nervous system regulates, how your inflammation behaves, how your metabolism truly performs.
Wait until you see how I design your supplementation from that, not from a single genetic snapshot.

Then, if after all of that, you still want me to review your methylation test,
I will.

Two hours later, after going through all the data and his analysis — everything made sense.
He looked at me and said:
“I don’t think I need the methylation test anymore.”

That’s what happens when we stop guessing
and start reading what the body is actually saying.

Something new is coming — a way to build your health plan not on trends, but on data, physiology, and logic.
No more “take this, it might help.”
Only precision.

04/11/2025

We’ve entered an age where health is being confused with control.

More tests. More trackers. More data streams.
Blood biomarkers every quarter. Continuous HRV, sleep, glucose, temperature monitoring.
Hundreds of supplements. Layer upon layer of biohacks.

Yet despite the precision, people feel worse.
Sleep is tracked, not restored.
Stress is measured, not resolved.
Energy is optimised on paper, but absent in life.

We’re witnessing a paradox: the more people monitor, the less they adapt.
Physiological flexibility is being replaced by digital rigidity.
Health has become a series of targets — not a living system.

What’s missing isn’t another metric.
It’s integration.
An intelligent way to connect data with function,
numbers with meaning,
biology with experience.

Because data without context doesn’t heal.
It only quantifies dysfunction.

The next phase in longevity and performance will not come from more measurement.
It will come from interpretation — understanding why systems lose rhythm,
and how to restore adaptability at the cellular, neuroendocrine, and metabolic levels.

That’s the direction we’re building toward —
a model that unites diagnostics, recovery, and rhythm.
Where science meets meaning.
And where prevention finally becomes vitality.

Coming soon.

28/10/2025

Treating disease is not enough.
We need to start taking behavioural change seriously in medicine.

We’re becoming increasingly skilled at treating the very conditions we continue to create — through stress, poor sleep, inactivity, and nutrition that works against us.

Change isn’t easy.
And it’s not enough to simply *suggest* it.

But it’s not impossible either.
Neuroscience and psychology give us powerful tools to make behaviour change real, measurable, and sustainable.

The first step?
The clinician must believe it’s possible.

Because if we don’t believe in change, our patients never will.

20/10/2025

Aging Is Inflammation + Dehydration

Most people think aging is about getting wrinkles, gray hair, or a slower metabolism.
But under the microscope, aging starts with something far more subtle — a loss of water inside your cells.

💧 Intracellular water (the water inside your cells) is a direct marker of cell vitality.
As it drops, your cells become less efficient at producing energy, detoxifying, repairing DNA, and controlling inflammation.

At the same time, extracellular water (the water outside your cells) starts to rise.
This shift — more “water retention,” less cellular hydration — signals an inflamed, catabolic, and aging system.

It’s not just a cosmetic issue.
A major study during the pandemic found that over 70% of older adults showed this exact pattern —
low bone density, reduced muscle mass, and increased fat and inflammation — a condition now known as Osteosarcopenic Adiposity.
(Cvijetić et al., Nutrients 2023)

That means aging isn’t simply about years passing.
It’s about how efficiently your body manages stress, inflammation, and hydration at a cellular level.

And here’s the thing — you can change it.
Because these shifts are not destiny.
They’re physiology.
And physiology can be measured, trained, and optimized.

🚀 We’ve been working on something that will do exactly that — and much more.
A complete way to decode your physiology, reveal what’s driving your biological aging,
and guide you toward recovery and performance from the inside out.

Stay tuned — it’s coming soon.

16/10/2025

💬 Why Chasing Biomarkers Isn’t Enough

We live in a time where everyone wants to know their numbers.
Blood tests every six months. Hormone panels. DNA reports.
Graphs, colours, ratios — the illusion of precision.

But here’s the truth most people never hear:
a biomarker doesn’t explain your health — it reflects it.

🩸 Numbers Without a Narrative

A blood biomarker is like a photograph.
It captures a moment, not the story behind it.
Your CRP is elevated — but why?
Your cortisol is high — but what system is keeping it that way?

You can’t fix a photograph by editing the pixels.
You fix it by changing what’s in front of the camera.

Yet this is what modern health check culture often gets wrong.
We chase the numbers, not the physiology behind them.
We measure fragments instead of understanding the system.

🧬 The Myth of the “Unchangeable” Code

Genetic testing has added to the confusion.
Many people think their genes decide everything about them, as if a few letters on a test can tell their whole future.

But the science of epigenetics has made one thing clear: genes load the gun, environment and physiology pull the trigger.

Stress, inflammation, sleep, nutrition, social enviornment and recovery all modify how your genes express themselves — for better or worse.

A predisposition to insulin resistance or inflammation is not a sentence. It’s a starting point.

And you can change the trajectory — if you act before your bloodwork starts to scream for help.

⚙️ Physiology First

Think of your body as an orchestra.
When something sounds off, blood biomarkers are the echo.
But the real imbalance happens long before —
in how your nervous system regulates stress,
how your cells handle energy and water,
how your tissues communicate under pressure.

That’s where modern physiology is heading:
not treating what’s already broken,
but reading the early whispers of dysfunction
— the pattern behind the numbers.

And this is where our work is now focused.
We’re building an analysis that looks beyond isolated lab values
to measure how your system performs as a whole —
how it adapts, regulates, and recovers.

Because real prevention doesn’t start when your blood is abnormal.
It starts when your physiology begins to drift.

🧠 Science Backs It

Chronic stress alters cortisol rhythm and cell hydration years before blood markers change (Tsigos et al., Eur. Clin. Invest., 2014).
HRV and phase angle can predict autonomic dysfunction and inflammation before disease manifests (Chrousos et al., Hormones, 2022).
Epigenetic studies confirm that environmental modulation—sleep, nutrition, stress regulation—can switch genes on or off (Feil & Fraga, Nature Rev. Genet., 2012).

Soon, we’ll introduce a new way to read your body —
not through random numbers,
but through patterns that tell you how and why those numbers shift.

Because true insight doesn’t come from testing more.
It comes from understanding deeper.

13/10/2025

Tired. Achy. Foggy. Yet every blood test says you’re fine.

We see this more often than you’d think.
People who feel persistently drained, inflamed, or mentally flat — but whose results come back “normal.”
Medicine calls them Medically Unexplained Symptoms.
But there’s nothing truly “unexplained” about them.

A large multicentre study of over 90,000 adults found that people in this group shared the same biological pattern:
🧠 A flattened or reversed cortisol rhythm — the stress system losing its natural balance.
🔥 Elevated low-grade inflammation (hs-CRP and cytokines quietly rising).
💧 And a shift in cellular hydration: less water inside the cell, more outside — an early sign of cell stress and loss of vitality.

These aren’t abstract numbers. They are physical fingerprints of chronic stress and inflammation — long before disease appears or blood values cross a red line.

New technologies now allow us to measure these imbalances directly, through non-invasive bio-impedance and heart-rate-variability analysis.
They reveal what traditional testing often misses: how our stress system, immune response and cellular integrity are interacting in real time.

We’re integrating this approach into a new analysis we’re about to launch soon — a way to see, quantify and rebalance what’s been invisible until now.

---

Reference:
Tsigos et al., European Journal of Clinical Investigation (2014). Stress and inflammatory biomarkers and symptoms are associated with bio-impedance measures.

10/10/2025

The System Beneath the System

We live in a world obsessed with optimization.
Tracking, supplementing, tweaking, and hacking every metric we can measure.
Yet despite all this… people are more fatigued, inflamed, anxious, and disconnected than ever.

How is that possible?

Because what we call health optimisation today is mostly noise, a fragmented, symptom-chasing approach built on a system that no longer serves us.

We’ve learned to measure the wrong things.
We’ve confused activity for progress.
We’ve built solutions on top of dysfunction instead of rebalancing what lies beneath it.

The truth is: the system is faulty.
It’s reactive instead of predictive.
It’s based on isolated snapshots instead of integrated intelligence.
It looks at numbers, not at people.

But what if we could see deeper?
What if we could read the language of your biology — the hidden signals that reveal how your body is truly adapting, recovering, and aging?

That’s what we’ve been building.
Quietly. Carefully. Relentlessly.

A new framework.
A new way to assess, guide, and regenerate human performance — from the inside out.

It’s not another wearable, supplement, or “wellness program.”
It’s something entirely different.

And it’s almost ready.

08/10/2025

🔬 When Precision Matters: Why Advanced Cellular Analysis Changes Everything

A patient recently came in with a popular body scan they had done elsewhere.
That device reported 41 kg of muscle mass.

A few days later, we performed a cellular bioelectrical analysis — same person, same week — and it showed 23 kg of true active muscle tissue.

How can two results differ so much?

Because most conventional scans measure everything that isn’t fat and label it “muscle” — including water, connective tissue, and other non-contractile components.

But when we’re analysing stress, recovery, and biological resilience, accuracy becomes everything.

⚙️ Chronic stress and systemic inflammation gradually break down cell membranes, reducing phase angle and cellular vitality.
This affects how well your body recovers, repairs, and maintains muscle — even if you look fit from the outside.

So if your scan can’t distinguish between inflamed, water-retaining tissue and metabolically active muscle, it will completely miss what’s really happening inside your body.

💡 That’s why a deeper, cellular-level approach is essential. It lets us see the real effects of stress, inflammation, nutrition, and training — not just their surface appearance.

📊 The next generation of human analysis is about understanding your biology, not guessing it.
Coming soon.

07/10/2025

🧬 Why Genetic Testing Isn’t the Answer

Over the past decade, genetic testing has become the ultimate health trend.
A saliva sample, a report, and suddenly — we’re told who we are, what to eat, and how to train.

But here’s the problem:
Genes don’t determine your destiny.
They determine your potential.

What truly shapes your biology is epigenetics — the dynamic system that turns genes on or off depending on how you live, breathe, eat, sleep, move, and manage stress.

Your DNA is the script.
Epigenetics is the director.

Research shows that factors like oxygen signaling, inflammation, sleep quality, and psychological stress constantly rewrite that script — influencing everything from mitochondrial function to immune response and aging speed (Nature Reviews Genetics, 2022; Cell Metabolism, 2023).

That means a genetic test can’t tell you how your system is performing today —
only what it might do under perfect conditions.

We are building something special, we’re not reading static blueprints.
We’re developing ways to measure how your biology adapts in real time — the shifting interplay between stress, recovery, oxygen, and cellular vitality.

It’s the next generation of human diagnostics and interventions.
And it’s coming soon.

Because the future of health isn’t in predicting who you are It’s in changing who you can become.

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My story, Emanuele Calabrese

English

My journey towards osteopathy begins in 2011, in Rome, driven only by love for anatomy and people care. In the summer of 2015 I realise that I want more than just a Diploma, I look to an unknown osteopathic world, and I discover I can get a Degree in this beloved profession. I take my bags and leave for Saronno where I will finish my studies in 2017 obtaining the Diploma in Osteopathy and most importantly, a Bachelor of Science in Osteopathy through the British College of Osteopathic Medicine of London.

I learned that opening your eyes and always looking forward helps to grow and improve, and therefore I have not stopped, I moved to London where today I am registered with the General Osteopathic Council and I work in different clinics.

This page is meant to be a place for sharing my opinions, experiences, impressions and anything about this wonderful science, Osteopathy. Whether you are an osteopath or just a curious person, you will find this space rich of interesting topics.

Please, feel free to leave a comment or share the contents!

Italiano

Il mio viaggio verso l'osteopatia inizia nel 2011, a Roma, spinto solo dall'amore verso l'anatomia e la cura della persona. Nell'estate del 2015 mi rendo conto di volere di più, mi affaccio su un mondo osteopatico fino a quel momento a me nascosto, e scopro di potere ottenere una Laurea in questa, da me tanto amata, professione. Faccio le valige e parto alla volta di Saronno dove terminerò i miei studi nel 2017 conseguendo il Diploma in Osteopatia ma soprattutto, un Bachelor of Science in Osteopathy tramite il British College of Osteopathic Medicine di Londra.

Ho imparato che aprire gli occhi e guardare sempre lontano aiuta a crescere e a migliorarsi, e quindi non ho smesso, mi sono trasferito a Londra dove oggi sono registrato con il General Osteopathic Council e lavoro in diverse cliniche.

Questa pagina vuole essere un luogo in cui condividere le mie opinioni, esperienze, impressioni e tanto altro su questa meravigliosa scienza, l’Osteopatia. Che tu sia un osteopata o solo una persona curiosa, troverai questo spazio ricco di argomenti interessanti.

Sentitevi liberi di lasciare un commento o condividere il contenuto!