19/03/2026
If you've got hypermobility or EDS and you've struggled with anxiety, I want you to know something. It's not in your head. Well, technically it is, but not in the way you've probably been told.
Research has found that those with joint hypermobility were around 17 times more likely to have panic disorder or agoraphobia compared to those without. Not slightly more likely. Around seventeen times. And multiple studies have consistently found this kind of association, so it's not a one-off finding.
But, here's where it gets really interesting. Brain imaging research has shown that those with hypermobility tend to have larger amygdalas, the part of your brain responsible for processing fear. A 2012 MRI study of 72 healthy volunteers (none of whom had clinical anxiety) found a significant difference in amygdala volume between those with and without joint hypermobility, with an effect size of around 0.8, which is large by any standard. So your brain's threat detection system is literally built differently.
Now, that's not the whole picture. Your nervous system is also involved. If you've got POTS or dysautonomia alongside your hypermobility, your heart can spike by 30 or more beats per minute just from standing up. That adrenaline surge mimics the exact symptoms of a panic attack, racing heart, breathlessness, dizziness. It's not surprising that a lot of people with hypermobility end up in mental health services being treated for panic disorder when the root cause is actually cardiovascular.
And then there's the gut connection. Around 90 to 95% of your body's serotonin is produced in the gut, not the brain. When you consider that gut disorders are more common in those with hEDS compared to the general population, it starts to make sense why anxiety can feel so physical and so persistent.
A 2022 systematic review looking across 23 studies found anxiety prevalence of up to 51.2% in some EDS cohorts. That figure comes from the higher end of the range, but even the lower estimates are well above what you'd expect in the general population.
So if you've been told it's "just anxiety" or to "try and relax", know that there are real, measurable, structural reasons why your body is wired this way. You're not weak. You're not making it up. Your biology is genuinely different.
We go into a lot more detail on the mechanisms, the research, and what actually helps in our full blog post (link in comments).
Have you experienced anxiety alongside your hypermobility? Did anyone ever explain the connection to you, or were you told it was "just stress"? Drop a comment, we'd love to hear your experience.