27/01/2026
Dual-payload ADCs won’t reach their full potential if they are designed by trial and error 🧪
Even as ADC pipelines are growing at record pace, tumor heterogeneity, resistance, and off-tumor toxicity remain major hurdles that often stand in the way of deeper and more durable clinical responses. Dual-payload ADCs are building a growing body of evidence showing how carefully combined cytotoxic mechanisms can help reach more tumor cells, slow the emergence of resistance, and move toward treatments that are both safer and more effective, ultimately offering more lasting relief for patients.
In this article, Jerzy Woźnicki, PhD discusses how Turbine’s Virtual Lab and in silico disease models can be used to screen and stress-test dual-payload combinations before they ever reach the bench, and how this approach helps uncover where the mechanisms behind true synergy and resistance are most likely to emerge. 🔬🖥️
Read the full article here 👇
Dual-payload ADCs are gaining traction, offering opportunities to overcome the tumour heterogeneity and resistance challenges faced by conventional ADCs.