20/04/2021
Copied from the wall of Dr J K Bhutani ..I totally endorse his views which are based on the best evidence...
'WHAT do not work in COVID are Azithromycin, Doxycycline, Ivermectin, Hydroxychloroquine, Vitamins, and Oseltamivir clones….
What works in some are steroids, low-molecular-weight heparin, and in very early and very few Remdesivir…
Patients with severe or moderate hypoxia, which generally occurs after a week of onset of symptoms, are treated with supplemental oxygen…
The optimal oxygen saturation (SpO2) in adults with COVID-19 is uncertain...
A target SpO2 of 92% to 96% seems logical and beneficial…
The experience in patients in observational studies of COVID-19, suggests that a SpO2 96% may be harmful….
SpO2 of 88% to 92% and SpO2 of >96% were both associated with higher mortality....
The conventional oxygen therapy or options for providing enhanced respiratory support including HFNC, NIPPV, intubation, and invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) logically should have a similar target of, SpO2 92%....
Too much oxygen, unmonitored or casually monitored oxygen therapy often is associated with reactive inflammation, growth of microbes (bacteria, and fungi) leading to superadded lung infections, induction of subsequent fibrosis, and restrictive lung disease….
Nearly nothing is even known about the effect of therapeutic administered oxygen on the expression of ACE2 and Furin in respiratory tissues and possible long-term outcomes….
Some generation of ‘oxygen radicals’ may not be bad, as phagocytic cells generate radicals to kill invading pathogens…..
But too much reactive oxygen can be toxic to cells and possibly damaging to many macromolecules, including lipids, proteins, and inhibitory mutant or autoimmune triggers…
As most of the data and published work on COVID-19. is observational, anecdotal or subjectively biased, clinical, and not based on randomized controlled trials…
An astute clinician shall facilitate the immune response of the patient, with watchful expectant expediency, while looking for more mysteries of the body, COVID, and medical science to reveal….
The majority of the patients will get well on their own with just supportive treatment and no drug, oxygen, or device intervention…
post-COVID sequelae and the genesis of these in the panic responses of the medical science to the pandemic is a worthwhile compassionate consideration…'