GP Clinics

14/10/2023

Hi Friends!

We are starting our 2nd series of 12 webinars with Dr YK Amdekar from tomorrow i.e., 15th Oct, 2023. There was an overwhelming response to our 1st series, and on popular demand by doctors from all across India, that we are starting this 2nd series.

Stay tuned at 11am, Sunday, Oct 15th, 2023.

You may register at https://docislive.com

The recordings of all our previous webinars of 1st series is there on our website www.gpclinics.in and on our Docislive.com YouTube Channel.

With warm regards,
Dr Anupam Aggarwal, MD
Editor and Publisher, GP Clinics,
clinicsindia and docislive.com

25/06/2022

15/08/2019

Avail Independence Day bumper offer at www.gpclinics.in on GP Clinics subscription. Offer is open till midnight tonight...

02/07/2019

20/03/2019

Let the colors of Holi spread the message of peace and happiness.

Happy Holi😇😇😇😇

19/03/2019

5 New Diabetes Categories Proposed

The authors of a recent study have proposed 5 new classifications for patients with diabetes in hopes of tailoring future treatments and targeting early treatments to patients with the condition.

The proposal was formed following the completion of a data-driven cluster analysis of 8980 patients with newly diagnosed diabetes who were enrolled in the Swedish All New Diabetics in Scania cohort.

Ultimately, the researchers categorized patients into the following 5 clusters:
- Severe autoimmune diabetes (formerly type 1 diabetes)
Severe insulin-deficient diabetes
Severe insulin-resistant diabetes
Mild obesity-related diabetes
Mild age-related diabetes

Patients were assigned to a cluster based on the presence of glutamate decarboxylase antibodies, age at diagnosis, body mass index, hemoglobin A1c levels, and homoeostatic model assessment of 2 estimates of ß-cell function and insulin resistance.

To know details and subscribe to GP Clinics - A CME Journal for Family Physicians. Visit -http://gpclinics.in/

16/03/2019

Could Pasta AID Weight Loss Efforts?

In the context of low-glycemic index (GI) dietary patterns, pasta consumption is not associated with weight gain and may actually have beneficial effects on body weight and body mass index (BMI), according to new research.

Researchers arrived at this conclusion following a systematic review and meta-analysis of 32 trials (N = 2448). During their analysis, they compared findings regarding the effects of pasta consumption on measures of global and regional adiposity in adults.

Specifically, the researchers examined the effects of pasta in the context of low-GI dietary patterns on body weight, BMI, body fat, waist circumference, waist-to-hip ratio (WHR), and sagittal abdominal diameter (SAD).

The generic inverse-variance method was used to pool data and determine mean differences, and the GRADE system was used to assess the certainty of evidence.

Results revealed that, among individuals with low-GI dietary patterns, pasta consumption was associated with significantly reduced body weight (mean difference -0.63 kg) and BMI (mean difference 0.26 kg/m2) compared with those with high-GI dietary patterns.

However, no effect of pasta consumption was observed for other adiposity measures, with evidence grades of “moderate” given for body weight, BMI, WHR, and SAD, and a grade of “low” given for waist circumference and body fat.

“Pasta in the context of low-GI dietary patterns does not adversely affect adiposity and even reduces body weight and BMI compared with higher-GI dietary patterns. Future trials should assess the effect of pasta in the context of other ‘healthy’ dietary patterns.

To know details and subscribe to GP Clinics - A CME Journal for Family Physicians. Visit -http://gpclinics.in/

14/03/2019

Study: One High-Fat Meal Could Induce Metabolic Changes in the Liver

A single oral dose of saturated fat impaired hepatic metabolic responses and increased the risk for developing nonalcoholic fatty liver disease (NAFLD) and insulin resistance in healthy adults, according to a new study.

The study included 14 healthy, nonobese men who were randomly assigned to consume a glass of water or a glass of flavored palm oil. Researchers measured the effects of palm oil on the metabolism using in vivo 13C/31P/1H and ex vivo 2H magnetic resonance spectroscopy before and during hyperinsulinemic-euglycemic clamps with isotope dilution.

The palm oil solution contained a saturated fat content equal to a cheeseburger (110-grams with 18-25 grams per 1000 kcal of saturated fat) and large portion of French fries (7-14 grams per 1000 kcal of saturated fat), or an 8-slice pepperoni pizza (approximately 16.72 grams of saturated fat/110 grams) In addition, researchers performed the same experiment using a mouse model.

Analysis of data from human participants showed that the palm oil solution decreased whole-body insulin sensitivity by 25%, hepatic sensitivity by 25%, and adipose tissue sensitivity by 34%. Likewise, hepatic triglyceride content rose by 35%, and hepatic adenosine triphosphate (ATP) content rose by 16%. The net glycogenolysis declined by 20%, and the hepatic gluconeogenesis (GNG) increased by 70%. In addition, the analysis of mouse transcriptomics showed that palm oil differentially regulated upstream regulators and pathways, including lipopolysaccharides (LPS), members of the toll-like receptors (TLR) and family peroxisome proliferator-activated receptors (PPARs) families, NF?B, and TNF-related weak inducer of apoptosis (TWEAK).

“Saturated fat ingestion rapidly increases hepatic lipid storage, energy metabolism, and insulin resistance. This is accompanied by regulation of hepatic gene expression and signaling that may contribute to the development of NAFLD,” the researchers concluded.

To know details and subscribe to GP Clinics - A CME Journal for Family Physicians. Visit -http://gpclinics.in/

10/03/2019

New Measurement Technique Suggests Lower Recommended Daily Vitamin D Intake

Using a new measurement technique, researchers have found that the recommended dietary allowance (RDA) for vitamin D intake could be lowered from 800 international

units (IU) to 400 IU per day. In the past, the Institute of Medicine, World Health Organization, and the European Food Safety Authority have suggested that a serum 25-hydroxyvitamin D (25OHD) level of 20ng/ml is adequate to prevent fractures. Previous research has reported that 800 IU of vitamin D daily would allow 97.5% of the population to meet this requirement. However, these estimates were based on analysis using immunoassay.

Now, using liquid chromatography-mass spectrometry, researchers reevaluated samples originally measured with immunoassay in order to test their original estimations.

In the original study, the researchers randomly assigned 163 postmenopausal Caucasian women with vitamin D insufficiency, aged 57 to 90 years, to 1 of 7 vitamin D doses: 400,800, 1600, 2400, 3200, 4000, 4800 IU/day or to placebo, for 1 year. After reevaluating the results with liquid chromatography-mass spectrometry, the researchers reported that a daily dose of 400 IU would exceed a serum 25OHD level of 20ng/ml and that an intake of 800 IU per day would exceed a serum 25OHD level of 30ng/ml.

“In estimating the RDA for vitamin D intake the method used for measuring serum 25-OH-D is an important consideration. Based on the [immunoassay] system the estimated RDA to exceed 20ng/ml was 800 IU daily whereas [liquid chromatography-mass spectrometry] estimated that 400 IU daily would meet the RDA. This has important ramifications for public health recommendations,” the researchers concluded.

To know details and subscribe to GP Clinics - A CME Journal for Family Physicians. Visit -http://gpclinics.in/

08/03/2019

High-Dose Vitamin D Can Prevent Respiratory Infection In Older Adults

A high dose of vitamin D can prevent acute respiratory infection (ARI) in older adults living in long-term care facilities, according to new research.

Vitamin D is believed to bolster the immune system, which makes it an optimal supplement for older adults. However, this is the first study to examine the impact of vitamin D on residents of long-term care facilities.

The researchers conducted a 12-month randomized controlled trial including 107 adults aged 60 years and older.

Residents were randomly assigned to either a high-dose or a standard-dose of vitamin D supplementation.

Those in the high-dose group received 100,000 IU/m, those in the standard-dose group already taking 400-1000 IU/d received a placebo, and those in the standard-dose group already taking less than 400 IU/d received 12,000 IU/m of vitamin D3.

Overall, a high-dose of vitamin D was associated with less ARIs. However, individuals in the high-dose group had a higher rate of falls, though fractures were uncommon.

“Monthly high-dose vitamin D3 supplementation reduced the incidence of ARI in older long-term care residents but was associated with a higher rate of falls without an increase in fractures,” the researchers concluded.

To know details and subscribe to GP Clinics - A CME Journal for Family Physicians. Visit -http://gpclinics.in/

07/03/2019

If you want to get a plan, go to a man but if you want it to be done, go to a woman.

Happy Women's Day😇😇😇

05/03/2019

Uspstf Updates Recommendations on Statin Use For Primary Prevention

The USPSTF has finalized recommendations on statin use for primary prevention, now recommending low- to moderate-dose statin use for adults aged 40 to 75 years without cardiovascular disease (CVD) who have at least one CVD risk factor and a 10-year CVD risk of 10% or greater.

The new guidelines come as an update to the 2008 USPSTF recommendations on screening for lipid disorders in adults.

The group reviewed available evidence on the benefits and harms of screening and treatment for dyslipidemia in adults, as well as the effects of statin use in reducing cardiovascular events and mortality in individuals without a history of CVD, and the effects of various treatments in adults without a history of CVD events.

In the new guidelines, the USPSTF recommends initiating low- to moderate-dose statins in adults aged 40 to 75 years without a history of CVD who have 1 or more CVD risk factors and a calculated 10-year CVD event risk of 10% or greater (B recommendation). They have also recommended that clinicians selectively offer low-to moderate-dose statins to adults aged 40 to 75 years without a history of CVD who have 1 or more CVD risk factors and a calculated 10-year CVD event risk of 7.5% to 10% (Crecommendation).

“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of initiating statin use for the primary prevention of CVD events and mortality in adults 76 years and older without a history of heart attack or stroke (I statement).”

To know details and subscribe to GP Clinics - A CME Journal for Family Physicians. Visit -http://gpclinics.in/