30/11/2025
Seizures are electrical storms, and anyone who has lived with epilepsy knows that these storms can roll in without warning. Beneath that activity lies the ECS, our Master Regulator, working to steady the flow of signals through the brain. When calcium floods into neurons too quickly, those cells fire in rapid chains that feed a seizure. The brain needs a system that can ease that surge, guide ion flow, and shift excitatory pathways back toward balance. That is where CBGa shows real strength.
The study Cannabigerolic Acid Is a Highly Potent Seizure Suppressant in a Mouse Model of Dravet Syndrome (2021) demonstrated that CBGa interacts with ion channels tied to neuronal firing. Calcium channels, sodium channels, and TRP receptors all play roles in how fast a neuron discharges and recovers.
When CBGa binds to specific TRP sites, especially TRPV1, it changes how calcium is allowed to move through the membrane. It does not shut the door; it steadies the swing. That steadier flow prevents the kind of runaway excitation that builds into a seizure.
Epileptic brains often struggle with overactive glutamate signalling and weakened GABA tone.
Without enough internal modulators to slow the cycle, electrical activity spreads across networks that should remain quiet. CBGa supports the upstream pathways that feed those modulators, allowing the Master Regulator to keep excitation and inhibition at a healthier rhythm. Patients feel that shift as fewer spikes, less aura activity, and more room for the brain to recover between stressors.
There is also the mitochondrial angle. Calcium overload stresses those little power units, leading to oxidative strain that tightens the seizure threshold. CBGa supports a healthier mitochondrial tone, helping neurons withstand stress without collapsing into hyperexcitability. That protection matters for long-term seizure control because a calmer calcium flow equals calmer circuits.
When the Master Regulator has what it needs, seizure thresholds rise, storms settle faster, and the brain finds the balance it has been missing.
Reach out if you need more information or a consultation.
-Mike Robinson, The Researcher OG
