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ResaPura Lavorazione Canapa per conto terzi. Cosmetici cbd/cbg

20/12/2025

Peripheral neuropathy is one of those conditions that does not always scream loud, but it never truly shuts up. Tingling, burning, numbness, electric pain, weakness, loss of temperature sense, and that constant reminder that the nerves are not communicating the way they should. For many patients, conventional medicine offers symptom management at best, often wrapped in drugs that dull the body while never addressing the underlying signaling breakdown.

This is where cannabinoids enter the conversation in a way that makes biological sense. The ECS, our Master Regulator, is deeply involved in peripheral nerve signaling, immune modulation, and pain perception. CB1 receptors are present along peripheral nerve pathways and influence how pain signals are transmitted to the brain, while CB2 receptors are heavily involved in immune response and neuroinflammation, two key drivers of neuropathic pain.

A well-known clinical trial published in 2015 in The Journal of Pain titled “Inhaled cannabis for chronic neuropathic pain: a meta-analysis of individual participant data” showed that cannabinoids significantly reduced neuropathic pain compared to placebo, even in patients who had failed multiple other treatments. Importantly, the study highlighted that cannabinoids worked differently from opioids or gabapentinoids, improving pain without completely disconnecting sensory awareness.

What makes cannabinoids unique in neuropathy is that they do not simply block pain. They modulate it. They influence ion channels, inflammatory signaling, and neurotransmitter release in damaged nerves, helping calm hyperexcitable pathways while supporting overall neural communication. Cannabinoids like THC, CBD, CBG, and CBGa each play different roles depending on the patient’s ECS tone, the cause of nerve damage, and the level of inflammation involved.

This explains why some patients experience reduced burning, improved sleep, and better motor control rather than just numbness. The goal is not to shut off the nerves. The goal is to restore functional signaling where possible and reduce the inflammatory noise that keeps nerves firing incorrectly.

Peripheral neuropathy is not a single disease, and there is no single cannabinoid answer. What works is respecting the complexity of the nervous system and working with it instead of against it. When cannabinoids are used to support ECS Balance rather than overwhelm receptors, patients often find relief that feels more natural and sustainable.

That is not masking symptoms. That is helping the nervous system remember how to communicate again. Reach out and let’s talk if you need information about cannabinoids and this issue.

-Mike Robinson, The Researcher OG

16/12/2025

La ricerca scientifica sulla cannabis vive una fase di crescita senza precedenti, con migliaia di nuovi studi che ampliano conoscenze e applicazioni terapeutiche

06/12/2025

Chronic back pain is one of those conditions that settles in and shapes a patient’s life from the moment they wake up. Muscles clamp down, nerves stay irritated, and inflammation becomes the background noise the body cannot quite turn off. When cannabinoids step in for this type of pain, they are not acting as simple painkillers. They are helping the ECS, our Master Regulator, regain control over the signaling loops that drive persistent discomfort.

A clear example comes from the study "Cannabinoid Receptor Agonists and Antagonists as Analgesics" (2020), which showed how cannabinoids influence pain transmission through both the CB1 and CB2 pathways. That work helped clarify why THC shifts the perception of pain while CBD, CBGa, and CBDa influence the chemical landscape that keeps nerves inflamed.

THC helps turn down the volume on those amplified nerve messages that travel from irritated spinal tissue to the brain. CBD and CBGa help the body regulate inflammatory processes that wrap tightly around the spine and create muscle guarding. When those tissues settle down, the nerves stop firing the same distress signal on a loop.

CBDa supports this from another angle by influencing inflammatory pathways that run through the soft tissues and joint structures of the back. The acids give the Master Regulator room to reorganize the pain response so the body stops chasing itself in circles. Mobility improves, tension drops, and the patient feels a return of internal steadiness instead of the familiar burn that pushes them into fatigue.

Every patient is different. Some rely on THC for function, while others stabilize with morning CBGa. What matters is that cannabinoids give the Master Regulator the tools it needs to reshape how pain signals flow. When the system can do its job, the relief feels natural, not forced, and chronic back pain loses the grip it held for far too long.

-Mike Robinson, The Researcher OG

06/12/2025

Melanoma is one of the cancers that teaches us how the ECS, our Master Regulator, steps into the fight long before we ever notice something on the skin. Cannabinoids support that system by giving cells the signals they need to protect themselves, slow abnormal growth, and calm the inflammation that often fuels the disease.

What we learned years ago still holds strong today. In the study titled "Cannabinoids Reduce Tumor Growth in Mice with Melanoma" in 2006, we saw how targeted cannabinoids helped shrink melanoma tumors by influencing cell survival and immune signaling. That work opened the door to deeper research into how plant-derived actives and our own endocannabinoids create a defense network.

A patient with melanoma faces more than a spot on the skin. They face an immune system trying to correct faulty signals as inflammation builds. Cannabinoids like CBD, CBG, and CBGa interact with receptors across the skin and immune pathways that influence how cells grow, divide, and repair.

Those compounds help normalize oxidative stress, which is one of the biggest threats to tissue healing. This gives the internal system a clearer path to regulate growth patterns and encourage apoptosis where needed. That is a significant protective effect for someone navigating melanoma.

The Master Regulator uses Anandamide and 2AG to manage inflammation and cellular stress, though both can drop fast under fear, pain, or disease pressure. When cannabinoids support those pathways, the internal tone rises, which strengthens the pushback against aggressive cell behavior. That is why so many patients report reduced pain, better recovery, and calmer skin when they use a thoughtful profile of cannabinoids during treatment.

This is not about claiming a cure; it is about restoring the system the body depends on for defense. When you support the ECS, you give each cell a better chance at correction rather than chaos. That is the heart of cannabinoid protection in melanoma, and it is why I have focused so much of my career on teaching patients how to work with their internal system rather than fight against it. If you need more depth on how to apply this science in real life, reach out for a consult.

-Mike Robinson, The Researcher OG

05/12/2025

When someone asks why a balanced profile of full-spectrum CBGa, CBD, or THC extracts plays such a central role in healing, I remind them that the ECS, our Master Regulator, works like an internal conductor that pulls every system into tune. You can hit single notes with isolates, but when you bring the full band together, you get signaling that reaches deeper. CBGa steps in first, setting receptor tone and pushing the body to create its own messenger molecules.

CBD follows by easing the inflammatory load and helping neurons recover from stress. THC fills in the gaps by enhancing retrograde signaling, giving patients with pain or neurological tension a better shot at real relief instead of chasing a feeling that fades with tolerance.

These extracts carry botanical actives, minor cannabinoids, terpenes, and polyphenols that shift immune balance, support mitochondrial output, and calm excessive firing in sensory pathways. This is synergy, not hype. When the body receives that full-spectrum toolkit, cells communicate with more clarity, neuroimmune tone steadies, and the Master Regulator gets the range it needs to bring a patient back toward equilibrium.

One of the strongest demonstrations of this broad healing potential came from Cannabinoids Reduce Inflammation via Regulation of Immune Cell Migration (2009). The study showed how plant cannabinoids guide immune behavior in ways that single compounds cannot. That aligns with what I have seen for years across thousands of patients. Cells listen better when the extract carries a balanced voice.

You can use a narrow approach and hope the body fills in the missing pieces, or you can work with a spectrum that mirrors what the plant intended. Balanced extracts give the ECS the leverage it needs to restore function, rebuild tone, and help a patient heal from the inside out.

Contact me for a consult or more information on this topic

-Mike Robinson, The Researcher OG

30/11/2025

Seizures are electrical storms, and anyone who has lived with epilepsy knows that these storms can roll in without warning. Beneath that activity lies the ECS, our Master Regulator, working to steady the flow of signals through the brain. When calcium floods into neurons too quickly, those cells fire in rapid chains that feed a seizure. The brain needs a system that can ease that surge, guide ion flow, and shift excitatory pathways back toward balance. That is where CBGa shows real strength.

The study Cannabigerolic Acid Is a Highly Potent Seizure Suppressant in a Mouse Model of Dravet Syndrome (2021) demonstrated that CBGa interacts with ion channels tied to neuronal firing. Calcium channels, sodium channels, and TRP receptors all play roles in how fast a neuron discharges and recovers.

When CBGa binds to specific TRP sites, especially TRPV1, it changes how calcium is allowed to move through the membrane. It does not shut the door; it steadies the swing. That steadier flow prevents the kind of runaway excitation that builds into a seizure.
Epileptic brains often struggle with overactive glutamate signalling and weakened GABA tone.

Without enough internal modulators to slow the cycle, electrical activity spreads across networks that should remain quiet. CBGa supports the upstream pathways that feed those modulators, allowing the Master Regulator to keep excitation and inhibition at a healthier rhythm. Patients feel that shift as fewer spikes, less aura activity, and more room for the brain to recover between stressors.

There is also the mitochondrial angle. Calcium overload stresses those little power units, leading to oxidative strain that tightens the seizure threshold. CBGa supports a healthier mitochondrial tone, helping neurons withstand stress without collapsing into hyperexcitability. That protection matters for long-term seizure control because a calmer calcium flow equals calmer circuits.

When the Master Regulator has what it needs, seizure thresholds rise, storms settle faster, and the brain finds the balance it has been missing.

Reach out if you need more information or a consultation.

-Mike Robinson, The Researcher OG

29/11/2025

A cannabis extract has been linked to reduced pain and improved sleep and physical function in adults with chronic low back pain (CLBP) without serious side effects or addiction, new phase 3 data suggested. http://ms.spr.ly/6188tn44m

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