03/12/2025
妊娠高血圧腎症にも実験モデルがあるのですね
AJOG Expert Review in Preeclampsia: The etiology of preeclampsia - Experimental evidence that uterine ischemia during pregnancy causes hypertension
A, In the Goldblatt model of renovascular hypertension, clamping the renal artery leads to development of hypertension through renal ischemia and the release of renin in nonpregnant animals. B, By contrast, clamping the aorta below the renal arteries does not induce hypertension in nonpregnant animals. C, Clamping of the aorta in pregnant animals below the renal arteries leads to hypertension. D, The hypertension disappears after a hysterectomy has been performed; this suggests that the source of the signals leading to maternal hypertension is the gravid uterus. https://ow.ly/8zh650XAye5