Yotsuba Japan Company, 大阪府大阪市北区梅田2-2-2 ヒルトンプラザウエストオフィスタワー19階, Osaka (2026)

31/03/2026

Persistent breakouts of acne in adults are rarely just about clogged pores or skincare mistakes. In most cases, they reflect a combination of underlying processes that go beyond the surface.
Many people focus only on topical care - cleansing, acids, retinoids. Skin may look better for a while, but breakouts tend to return. Adult acne is often not only a surface-level issue.
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𝘚𝘦𝘷𝘦𝘳𝘢𝘭 𝘪𝘯𝘵𝘦𝘳𝘯𝘢𝘭 𝘮𝘦𝘤𝘩𝘢𝘯𝘪𝘴𝘮𝘴 𝘤𝘢𝘯 𝘪𝘯𝘧𝘭𝘶𝘦𝘯𝘤𝘦 𝘴𝘬𝘪𝘯 𝘤𝘰𝘯𝘥𝘪𝘵𝘪𝘰𝘯 𝘢𝘵 𝘵𝘩𝘦 𝘴𝘢𝘮𝘦 𝘵𝘪𝘮𝘦:
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1. Fluctuations in blood glucose: leads to increased sebaceous gland activity
2. Hormonal signaling: leads to higher sebum production
3. Inflammatory responses: leads to initiation and persistence of breakouts
4. Oxidative stress: leads to cellular damage and slower recovery
5. Liver load: leads to reduced efficiency of metabolic waste processing
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As a result, the skin becomes congested more easily, inflammation lasts longer, and recovery slows down.
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Why skincare alone doesn’t always lead to stable results?
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Topical products act on the outer layer of the skin - they cleanse, regulate cell turnover, and partially reduce inflammation.
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At the same time, internal factors like 𝘴𝘦𝘣𝘶𝘮 𝘱𝘳𝘰𝘥𝘶𝘤𝘵𝘪𝘰𝘯, 𝘣𝘢𝘴𝘦𝘭𝘪𝘯𝘦 𝘪𝘯𝘧𝘭𝘢𝘮𝘮𝘢𝘵𝘪𝘰𝘯, 𝘢𝘯𝘵𝘪𝘰𝘹𝘪𝘥𝘢𝘯𝘵 𝘤𝘢𝘱𝘢𝘤𝘪𝘵𝘺 𝘢𝘯𝘥 𝘮𝘦𝘵𝘢𝘣𝘰𝘭𝘪𝘤 𝘳𝘦𝘨𝘶𝘭𝘢𝘵𝘪𝘰𝘯 remain unchanged. This is why results can be incomplete or inconsistent.
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What is considered in a more comprehensive approach?
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— modulation of inflammatory processes
— antioxidant support
— liver function support
— influence on sebum regulation and keratinization
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👇 👇

24/03/2026

NMN Sirtuin Booster Complex
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Advanced formula designed to support cellular energy, metabolic function, and long-term vitality.
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NAD+ is a key molecule involved in how cells produce energy and maintain normal repair processes. Its levels naturally decline over time. NMN serves as a precursor to NAD+, helping support this pathway.
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The formula combines NMN with complementary compounds selected for their roles in antioxidant protection, cellular renewal, and structural support.
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-NMN
Supports NAD+ levels linked to cellular energy and maintenance
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-Trans-Resveratrol
Supports antioxidant defense and vascular function
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-Polyamine-rich Yeast Extract
Supports cellular renewal and metabolic activity
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-Peucedanum japonicum
Provides polyphenols that support circulation and oxidative balance
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-Sakura Extract
Supports collagen integrity and helps reduce glycation-related changes in skin

16/03/2026

Ceramides have become one of the most talked-about ingredients in skincare. They are essential lipids found in the outer layer of the skin and play a critical role in maintaining the skin barrier. Their main function is simple but fundamental: they help prevent water loss and protect the skin from environmental stress.

When ceramide levels decline, the barrier becomes weaker. The skin begins to lose moisture more easily, which can lead to dryness, rough texture, dullness, and reduced elasticity.

This is why many modern creams and serums include ceramides — they support the skin barrier from the outside.

But healthy skin structure depends on more than the surface layer.

Deep within the skin, the extracellular matrix is built from structural components such as collagen, elastin, proteoglycans, and hyaluronic acid. These molecules are responsible for the density, elasticity, and hydration capacity of the tissue.

For this reason, supporting the skin from within has become an important part of a comprehensive approach to skin health.

Our formula focuses on these structural elements.

At the center of the supplement is collagen tripeptide — a specific form of collagen composed of three amino acids: glycine, proline, and hydroxyproline. Due to its small molecular size, collagen tripeptide is more readily absorbed and can be utilized by the body as a building material for connective tissues .

The formula also includes several components that support the structure and hydration of the skin:

• Rice-derived phytoceramides — help support the skin barrier and reduce transepidermal water loss
• Elastin — a key protein responsible for tissue elasticity
• Proteoglycans from salmon cartilage — molecules with a strong ability to retain water and support tissue renewal
• Hyaluronic acid — helps regulate tissue hydration and participates in collagen and elastin organization

This combination provides the body with structural components involved in maintaining connective tissues and skin integrity.

Because supporting the skin barrier is not only about what we apply on the surface — it also depends on the structural environment that exists within the tissue.

24/02/2026

Skin integrity, joint comfort, and connective tissue resilience are closely linked to collagen levels in the body.

As natural collagen production declines with age, the focus shifts to forms that are efficiently absorbed and biologically active.

Collagen Tripeptide consists of three amino acids — glycine, proline, and hydroxyproline — arranged in a short peptide structure. Due to its low molecular weight, it is readily absorbed in the intestine and utilized in collagen metabolism.

Clinical data associate tripeptide supplementation with improved skin elasticity and increased levels of type I collagen. Benefits have also been observed in joint function and bone density parameters.

The formula is further supported by ingredients that act within the extracellular matrix.

Rice-derived phytoceramides help maintain barrier function and reduce transepidermal water loss. Elastin supports tissue flexibility.

Salmon nasal cartilage–derived proteoglycans are known for their high water-binding capacity and their role in growth factor signaling. Hyaluronic acid contributes to tissue hydration and structural support. Isomaltooligosaccharides provide prebiotic activity.

The vitamin complex supplies essential cofactors involved in metabolic pathways.

31/01/2026

The word “detox” is usually understood as something that removes “toxins”, “slags”, or harmful substances from the body.
From a biological point of view, this understanding is inaccurate.

In 2024, a study published in the Journal of Hazardous Materials (Marchiandi et al.) examined endocrine-disrupting chemicals in non-alcoholic beverages and their relation to packaging materials.

The researchers analysed 162 products and found that around 90% contained at least one endocrine-active compound. The highest levels were detected in drinks packaged in metal cans, particularly bisphenols. In some scenarios, estimated daily intake exceeded the updated safety threshold established by the European Food Safety Authority.

The study did not discuss detox programs or ways to remove these substances from the body. It focused on exposure. The key point is that this exposure is chronic and unavoidable for most people, and it begins where food and drinks first interact with the body — in the gastrointestinal tract.

Environmental compounds such as bisphenols or PFAS are not “flushed out”. There is no physiological mechanism that simply cleans them away. Instead, the body responds through barrier function, immune regulation, inflammatory control, and metabolic processing.

From this perspective, the intestine is not just a digestive organ. It is a major interface between the environment and the body. Its epithelial integrity, microbiome balance, and immune signaling play a central role in how environmental stressors affect overall health.

When people talk about “detox”, what actually matters is not removal of imaginary “slags”, but how well these systems cope with constant environmental load.

OKINAWA Wild Herbs Active Enzymes
• Supports normal intestinal function under everyday environmental stress
• Helps maintain gut barrier integrity and microbiome balance
• Designed to support the body’s response to chronic, low-level environmental exposure
• Focuses on digestive efficiency and local immune regulation in the gut

24/01/2026

🌸 SAKULORA® — where Japanese science meets the delicate beauty of sakura

We are proud to introduce SAKULORA®, a next-generation postbiotic ingredient, launched for the European market for the first time by Yotsuba Japan.

SAKULORA® is a heat-killed postbiotic strain derived from sakura flowers, developed by a Japanese raw-material manufacturer with over 85 years of scientific expertise and a portfolio of 100+ functional ingredients used across the health, beauty, and nutraceutical industries.

Why SAKULORA® is a breakthrough

Advanced low-temperature extraction technology
Postbiotic (heat-killed) — stable, safe, and scientifically validated
Derived from sakura blossoms, a symbol of purity, renewal, and harmony
HFE / IFIA 2024 Award for technological innovation

✨ Key benefits

• Supports a healthy gut microbiome
• Contributes to immune balance
• Promotes skin radiance and inner glow
• Designed with women’s well-being in mind

🌸 The philosophy behind the name

SAKULORA® = SAKURA + FLORA

Sakura represents delicate beauty and renewal.
Flora represents the living microbial world.

Together, they embody the harmony of Japanese nature and science, working from within.

First launch for Europe

Yotsuba Japan is proud to be the company that introduced SAKULORA® to the European market for the first time, opening a new chapter in refined, science-backed probiotic innovation.

🌸 SAKULORA® is not just an ingredient —
it is a symbol of Japanese science, purity, and inner beauty.

15/01/2026

Recent updates from Japan’s National Health and Nutrition Survey indicate that mineral deficiency is becoming a persistent and widespread issue.

According to the latest data released by the Ministry of Health, Labour and Welfare of Japan, intake of key minerals such as calcium, magnesium, iron, and zinc remains below recommended levels across a large part of the population.

The situation has not improved even after revisions of dietary reference values.

Deficiency is particularly pronounced among women, older adults, and people with unbalanced diets.

As Japan’s population continues to age and dietary patterns shift, mineral insufficiency is increasingly viewed as a structural nutrition challenge rather than a temporary imbalance.

These findings are driving growing attention toward mineral supplementation and functional nutrition, not as short-term correction, but as part of long-term health maintenance strategies.

Current discussions focus on bone health, metabolic stability, cardiovascular risk, and overall resilience, highlighting the role of minerals as a foundational component of modern nutrition.

19/12/2025

OROLIPO is a functional dietary supplement designed for men with increased metabolic load.
Its purpose is to support uric acid balance, liver function, detox pathways, and cellular recovery — systems that are commonly stressed in adult male physiology.
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Elevated uric acid is not only associated with gout. It reflects a deeper imbalance between purine metabolism, renal excretion, liver load, and oxidative stress.
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This imbalance often develops silently and is frequently linked with metabolic syndrome, cardiovascular risk, kidney strain, high-protein diets, alcohol load, and sedentary lifestyle.
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OROLIPO addresses this problem through a four-component formula, where each ingredient works on a different but connected biological pathway:
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• regulation of uric acid handling,
• cellular and DNA-level support,
• antioxidant and detox gene activation,
• liver and vascular metabolic protection.
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The formula is built for daily use, stomach-friendly, and focused on mechanisms, not stimulation or short-term effects.
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OROLIPO is positioned for men who want structured metabolic support, not symptom masking.

14/12/2025

Why some people don’t feel “regular” ginseng
Many ginseng products mainly contain ginsenosides that need intestinal conversion into metabolites such as Compound K. Because gut bacteria and enzymatic activity differ between individuals, absorption and perceived effect can vary.
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What is different here
This formula uses Korean ginseng from the Kumgang region, cultivated for 4–6 years, then fermented with kimchi lactic acid bacteria to shift ginsenosides toward more bioavailable forms, including Compound K and Rg3, reducing reliance on individual intestinal conversion.
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For whom
•If you tried ginseng before and results were inconsistent
•If you want stamina support during fatigue or stress
•If you are sensitive to cold extremities / want circulation support
•If you want focus support under stress
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Key benefits
• Energy & anti-fatigue
• Immune support
• Circulation support
• Mental clarity & focus
• Blood glucose support
• Skin hydration & elasticity
• Men’s reproductive support

11/12/2025

A 2025 study published in Scientific Reports analysed over 3000 health and lifestyle parameters of adults in the Iwaki Health Promotion Project. Using AI and Bayesian network modelling, researchers identified five patterns seen more often in people who catch influenza. When several factors overlap, the risk rises by ~3.6×.
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1. Elevated blood glucose
Chronic glycaemic markers weaken immune cell function.
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2. History of pneumonia
Past severe respiratory infection often correlates with reduced airway defence.
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3. High workload & poor sleep
Sleep restriction disrupts immune-related hormones and increases viral susceptibility.
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4. Low-quality diet
Insufficient vegetables and protein reduce immune resilience.
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5. Allergic conditions
Chronic inflammation and nasal congestion compromise the upper airway barrier.
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These findings highlight that vulnerability to influenza is rarely driven by a single cause. It emerges from a combination of inflammation, metabolic status, mucosal health, diet and sleep quality.
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This systems-level view aligns well with nutrients that support multiple immune pathways simultaneously. One example is a formulation combining liposomal fucoidan, Ascophyllan, lactoferrin and mixed seaweed extracts, described in the data file.
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Liposomal fucoidan
Nanoencapsulation increases absorption (6× permeability; 17× membrane transfer) and preserves >90% through digestion. It activates macrophages, T-cells and NK cells—crucial for early antiviral defence.
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Ascophyllan
Shown to raise NK-cell activity by ~20% in adults and reduce inflammatory signalling, supporting individuals with stress, poor sleep or allergic inflammation.
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Lactoferrin
Binds iron, limits pathogen growth and modulates interferon pathways involved in antiviral responses.
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Seaweed extracts (nori, hijiki, wakame, kombu)
Provide antioxidants, polysaccharides and iodine, supporting mucosal immunity, oxidative balance and metabolic stability.
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Overall, the influenza study and the marine polysaccharide complex point to the same principle: strengthening immunity requires addressing several mechanisms at once—barrier function, innate immunity, inflammation and metabolic balance.

07/12/2025

Herpes is a virus that never fully leaves the body. It can remain inactive for long periods of time and reappear when the immune system is less responsive than usual. Because of this, recent research has shifted towards studying compounds that support innate immunity — the branch of the immune system that determines how effectively the body handles a new flare-up.

Himematsutake is one of the fungi that drew attention in this context. In several laboratory studies, its extracts enhanced the activity of immune cells involved in early antiviral defense and increased the production of signaling molecules that coordinate the immune response. These findings became the basis for more focused work on herpes simplex virus (HSV).

In preclinical experiments, Himematsutake extracts reduced HSV-1 activity and decreased virus-induced cell damage. Certain isolated fractions interfered with the earliest steps of viral infection, and some modified compounds strengthened the effect of acyclovir in laboratory models. In animal studies, these compounds reduced inflammation and led to milder infection outcomes. These are preclinical data, but they outline a clear direction for further research.

Another set of studies explored interactions with Epstein–Barr virus (EBV), a common herpesvirus that can remain in the body for years. In cell models, Himematsutake extracts weakened processes that help EBV-associated cells maintain prolonged survival and triggered their death. This is also early-stage research, but it suggests that the biological activity of these fungal compounds may extend beyond HSV.

Yotsuba Japan Company

31/03/2026

24/03/2026

16/03/2026

24/02/2026

31/01/2026

24/01/2026

15/01/2026

19/12/2025

14/12/2025

11/12/2025

07/12/2025

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