Yotsuba Japan Company

19/12/2025

OROLIPO is a functional dietary supplement designed for men with increased metabolic load.
Its purpose is to support uric acid balance, liver function, detox pathways, and cellular recovery — systems that are commonly stressed in adult male physiology.
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Elevated uric acid is not only associated with gout. It reflects a deeper imbalance between purine metabolism, renal excretion, liver load, and oxidative stress.
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This imbalance often develops silently and is frequently linked with metabolic syndrome, cardiovascular risk, kidney strain, high-protein diets, alcohol load, and sedentary lifestyle.
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OROLIPO addresses this problem through a four-component formula, where each ingredient works on a different but connected biological pathway:
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• regulation of uric acid handling,
• cellular and DNA-level support,
• antioxidant and detox gene activation,
• liver and vascular metabolic protection.
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The formula is built for daily use, stomach-friendly, and focused on mechanisms, not stimulation or short-term effects.
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OROLIPO is positioned for men who want structured metabolic support, not symptom masking.

14/12/2025

Why some people don’t feel “regular” ginseng
Many ginseng products mainly contain ginsenosides that need intestinal conversion into metabolites such as Compound K. Because gut bacteria and enzymatic activity differ between individuals, absorption and perceived effect can vary.
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What is different here
This formula uses Korean ginseng from the Kumgang region, cultivated for 4–6 years, then fermented with kimchi lactic acid bacteria to shift ginsenosides toward more bioavailable forms, including Compound K and Rg3, reducing reliance on individual intestinal conversion.
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For whom
•If you tried ginseng before and results were inconsistent
•If you want stamina support during fatigue or stress
•If you are sensitive to cold extremities / want circulation support
•If you want focus support under stress
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Key benefits
• Energy & anti-fatigue
• Immune support
• Circulation support
• Mental clarity & focus
• Blood glucose support
• Skin hydration & elasticity
• Men’s reproductive support

11/12/2025

A 2025 study published in Scientific Reports analysed over 3000 health and lifestyle parameters of adults in the Iwaki Health Promotion Project. Using AI and Bayesian network modelling, researchers identified five patterns seen more often in people who catch influenza. When several factors overlap, the risk rises by ~3.6×.
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1. Elevated blood glucose
Chronic glycaemic markers weaken immune cell function.
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2. History of pneumonia
Past severe respiratory infection often correlates with reduced airway defence.
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3. High workload & poor sleep
Sleep restriction disrupts immune-related hormones and increases viral susceptibility.
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4. Low-quality diet
Insufficient vegetables and protein reduce immune resilience.
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5. Allergic conditions
Chronic inflammation and nasal congestion compromise the upper airway barrier.
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These findings highlight that vulnerability to influenza is rarely driven by a single cause. It emerges from a combination of inflammation, metabolic status, mucosal health, diet and sleep quality.
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This systems-level view aligns well with nutrients that support multiple immune pathways simultaneously. One example is a formulation combining liposomal fucoidan, Ascophyllan, lactoferrin and mixed seaweed extracts, described in the data file.
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Liposomal fucoidan
Nanoencapsulation increases absorption (6× permeability; 17× membrane transfer) and preserves >90% through digestion. It activates macrophages, T-cells and NK cells—crucial for early antiviral defence.
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Ascophyllan
Shown to raise NK-cell activity by ~20% in adults and reduce inflammatory signalling, supporting individuals with stress, poor sleep or allergic inflammation.
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Lactoferrin
Binds iron, limits pathogen growth and modulates interferon pathways involved in antiviral responses.
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Seaweed extracts (nori, hijiki, wakame, kombu)
Provide antioxidants, polysaccharides and iodine, supporting mucosal immunity, oxidative balance and metabolic stability.
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Overall, the influenza study and the marine polysaccharide complex point to the same principle: strengthening immunity requires addressing several mechanisms at once—barrier function, innate immunity, inflammation and metabolic balance.

07/12/2025

Herpes is a virus that never fully leaves the body. It can remain inactive for long periods of time and reappear when the immune system is less responsive than usual. Because of this, recent research has shifted towards studying compounds that support innate immunity — the branch of the immune system that determines how effectively the body handles a new flare-up.

Himematsutake is one of the fungi that drew attention in this context. In several laboratory studies, its extracts enhanced the activity of immune cells involved in early antiviral defense and increased the production of signaling molecules that coordinate the immune response. These findings became the basis for more focused work on herpes simplex virus (HSV).

In preclinical experiments, Himematsutake extracts reduced HSV-1 activity and decreased virus-induced cell damage. Certain isolated fractions interfered with the earliest steps of viral infection, and some modified compounds strengthened the effect of acyclovir in laboratory models. In animal studies, these compounds reduced inflammation and led to milder infection outcomes. These are preclinical data, but they outline a clear direction for further research.

Another set of studies explored interactions with Epstein–Barr virus (EBV), a common herpesvirus that can remain in the body for years. In cell models, Himematsutake extracts weakened processes that help EBV-associated cells maintain prolonged survival and triggered their death. This is also early-stage research, but it suggests that the biological activity of these fungal compounds may extend beyond HSV.

03/12/2025

15/11/2025

Menstrual pain is often attributed to hormones alone, but the underlying biology is more complex.
Each month, the endometrium enters a renewal phase. During this process, some epithelial cells become more mobile — a shift known as epithelial–mesenchymal transition (EMT).
When EMT becomes more active than expected, the tissue responds with stronger inflammation, which increases sensitivity and discomfort.

The gut also plays an important role.
Around 90% of the body’s serotonin is produced in the intestine, where it influences motility and pain perception.
A balanced microbiota supports this pathway and helps maintain a calmer physiological state during the cycle.
Some gut bacteria can also produce equol, a metabolite of soy isoflavones with mild estrogen-like and anti-inflammatory properties.
Certain strains of Lacticaseibacillus paracasei may enhance this process, supporting hormonal and tissue stability.

Postbiotics provide another mechanism that contributes to balance.
These are not live bacteria but inactivated microbial components that interact with immune receptors through molecular signals.
They do not colonize the gut, yet they help regulate inflammation, support mucosal immunity, and stabilize epithelial barriers.
Heat-killed Lacticaseibacillus paracasei is one of the most studied examples: it shows the ability to modulate IL-10/IL-12, increase secretory IgA, and — in in-vitro models — reduce activity in pathways linked to EMT.

This is the postbiotic used in the Sakulora® Cherry Blossom Probiotic Multi Complex, which provides 50 billion heat-killed L. paracasei derived from cherry blossoms.
According to the developer’s data, the complex supports IgA, serotonin pathways, collagen and hyaluronic acid expression, and shows dose-dependent effects on EMT-related signaling.
The formula also includes vitamin D₃, iron, iodine, zinc from yeast, and highly bioavailable calcium from scallop shells, forming a comprehensive base for maintaining balance throughout the cycle.

02/11/2025

Each component of the formula was selected for stability, safety, and synergy.
Together, they form a daily foundation for calm energy, clear skin, and internal balance.

Nutritional base

• Yeast-bound minerals (zinc, copper, iodine, selenium): highly bioavailable and gentle on digestion (+22% zinc absorption vs. standard forms).

• Calcium from scallop shells: a natural marine mineral that supports bones and muscles.

• Vitamin D₃: improves calcium absorption and immune defense.

• Iron, magnesium, and full B-complex: support metabolism, blood formation, and steady energy.

02/11/2025

Each component of the formula was selected for stability, safety, and synergy.
Together, they form a daily foundation for calm energy, clear skin, and internal balance.

Nutritional base

• Yeast-bound minerals (zinc, copper, iodine, selenium):
highly bioavailable and gentle on
digestion (+22% zinc absorption vs. standard forms).

• Calcium from scallop shells: a natural marine
mineral that supports bones and muscles.

• Vitamin D₃: improves calcium absorption
and immune defense.

• Iron, magnesium, and full B-complex:
support metabolism, blood formation, and steady energy.