07/01/2026
Abnormal bleeding is one of the most common reasons women stop using the etonogestrel implant—even though it is one of our most effective contraceptive options.
The IMPLANET trial provides strong evidence that a short course of Norethisterone Acetate (10 mg daily) can safely and effectively stop prolonged bleeding in implant users. In this randomized controlled trial, nearly 9 out of 10 women stopped bleeding within 7 days, compared to less than half who received placebo. Bleeding also stopped faster, giving women more bleeding-free days in the first month.
Importantly, the treatment was well-tolerated, used in a simple outpatient setting, and supports better counseling, continuation, and confidence in implant use. While bleeding may recur later, this approach offers a practical, evidence-based option to manage a common concern—helping women continue a method that works.
Reference:
Andrade, M. C. R., & Yamaguti, E. M. M. (2026). Norethisterone for prolonged uterine bleeding associated with etonogestrel implant (IMPLANET): A randomized controlled trial. American Journal of Obstetrics and Gynecology, 234(1), 101–115.
Disclaimer:
Educational content only. Not intended as medical advice. Clinical decisions should be made by qualified healthcare professionals.
Presented by Dr. Wilmaree Tornalejo, Level 3 OB-GYN Resident, and Dr. Hannah Dazo, Postgraduate Intern.
Infographic concept by Dr. Hannah Dazo