07/02/2026
I get asked daily whether advanced longevity ingredients actually work when applied to the skin.
So let’s clear this up properly.
Ingredients like PDRN, exosomes, growth factors, stem cells, collagen, NAD, and NMN do not function topically in a meaningful way. These molecules are either too large, unstable, or biologically dependent on systemic delivery to impact cellular pathways.
What does work topically are ingredients that interact directly with the skin barrier and epidermal signaling pathways. Think hyaluronic acid for hydration, ceramides for barrier repair, peptides for communication, retinoids for renewal, vitamin C for antioxidant protection, tranexamic acid and azelaic acid for pigmentation, niacinamide for barrier strength, and well-formulated oils for lipid support.
The confusion comes from a familiar industry pattern. When something works systemically or via injection, it quickly gets repackaged into a cream or serum and marketed as if the delivery method no longer matters.
Biology doesn’t work that way.
Topicals support the surface and signaling.�Systemic nutrients build structure, energy, and repair capacity.�Both matter, but they are not interchangeable.
For ingredient education, product vetting, and routines that respect how skin actually functions, visit thebeautydoctrine.com.
Be well. Be safe. Be beautiful!
Nadia
REFERENCES
1. Elias PM. Skin barrier function. Current Allergy and Asthma Reports.�https://pubmed.ncbi.nlm.nih.gov/16091244/
2. Bos JD, Meinardi MM. The 500 Dalton rule for skin pe*******on. Experimental Dermatology.�https://pubmed.ncbi.nlm.nih.gov/10839713/
3. Sinclair DA, Guarente L. NAD+ biology and aging. Cell.�https://pubmed.ncbi.nlm.nih.gov/30096311/
4. Rajman L, Chwalek K, Sinclair DA. Therapeutic potential of NAD-boosting molecules. Nature Communications.�https://pubmed.ncbi.nlm.nih.gov/31519831/
5. Sundaram H et al. Topical peptides and skin aging. Journal of Cosmetic Dermatology.�https://pubmed.ncbi.nlm.nih.gov/18492184/
6. Baumann L. The role of ceramides in skin barrier function. Dermatologic Therapy.�https://pubmed.ncbi.nlm.nih.gov/17970891/
7. Farris PK. Topical vitamin C: a useful agent for treating photoaging. Dermatologic Surgery.�https://pubmed.ncbi.nlm.nih.gov/18492184/
8. Draelos ZD. The role of niacinamide in dermatology. Dermatologic Surgery. https://pubmed.ncbi.nlm.nih.gov/16029679/
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