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Dental and Medical Problems is an international, peer-reviewed, open access journal covering aspects of oral sciences and general medicine, published bimonthly by Wroclaw Medical University.

02/12/2025

🔬 New Evidence: Vitamin D Strengthens Anti-Cancer Therapy in Oral Squamous Cell Carcinoma

Strong cancer medications can cause challenging side effects, but a new study shows that adding calcitriol (active vitamin D) may enhance the effectiveness of buparlisib, even when the dose is reduced. This could mark an important step toward developing safer and more targeted treatment options for individuals with oral squamous cell carcinoma.

What the results could mean for patients:
▫️ Calcitriol may allow doctors to use reduced doses of buparlisib while keeping its anticancer effect strong.
▫️ Lower treatment intensity could help reduce side effects and improve comfort during therapy.
▫️ If confirmed in further studies, this combination may become a future option in oral cancer care.

🔗 Read more: https://dmp.umw.edu.pl/en/article/2025/62/5/891/

27/11/2025

🔬 Redefining Evidence in Dental Research

The future of dental research may depend less on inventing new materials and more on redefining how we measure evidence. For decades, Cohen’s universal effect-size thresholds shaped clinical interpretation — even though they never truly reflected the realities of dental science.

A new, comprehensive analysis of 4,250 studies and 135 meta-analyses finally reveals that dentistry follows its own statistical patterns — and deserves its own, discipline-specific benchmarks.

🔍 Key insights from two decades of data:

• Typical within-group effects: r ≈ 0.16, 0.40, 0.67
• Typical between-group effects: g ≈ 0.10, 0.35, 0.86
• Huge variation between subfields: prosthodontics often labels effects above g ≈ 3 as “large,” while periodontology peaks around g ≈ 0.63
• Sample sizes matter: detecting small effects requires hundreds of participants; large effects may need as few as a dozen
• Inflation bias is low: published results are relatively stable and reliable

Where clinical judgment meets statistical rigor, better benchmarks lead to better decisions. These new, dentistry-specific effect-size standards will help researchers design stronger studies and give clinicians a clearer sense of what truly counts as a meaningful effect.

🔗 Read more: https://dmp.umw.edu.pl/en/article/2025/62/5/907/

🔊 Listen to the podcast: https://on.soundcloud.com/Tf1WTK1hW1Gss6Dggt

25/11/2025

🚨 Global WFLD Consensus: A New Era for Minimally Invasive Caries Management

Dental caries is the most common disease in the world, and despite decades of research, there has been no unified, evidence-based global guidance on how lasers should be used in its prevention and treatment.

The World Federation for Laser Dentistry (WFLD) has released a historic global consensus — the comprehensive international guideline defining evidence-based laser protocols for prevention, remineralization, selective caries removal, and improved restorative outcomes.

This consensus confirms what many clinicians already see daily: laser-assisted dentistry is transforming patient care by providing more precision, less discomfort and better preservation of healthy tooth structure. As research grows and training becomes more widespread, lasers are set to become an essential part of routine dental practice.

🔗 Read more: https://dmp.umw.edu.pl/en/article/2025/62/5/783/

18/11/2025

🌿 Innovative Research on Natural Inhibitors of Porphyromonas gingivalis

A newly published study provides interesting insights into the potential of natural phytocompounds in periodontal therapy. Researchers investigated 4-caffeoylquinic acid (4-CQA), a phenolic antioxidant derived from Moringa oleifera, and its ability to inhibit Lys-gingipain — one of the most critical virulence factors of Porphyromonas gingivalis, the keystone pathogen driving chronic periodontitis.

Using advanced in silico molecular docking and molecular dynamics simulations, the study demonstrated strong binding affinity between 4-CQA and Lys-gingipain, supported by multiple hydrogen-bond interactions and stable RMSD values throughout the simulation. These results highlight how naturally occurring compounds may disrupt bacterial pathogenicity by targeting the proteases essential for colonization, nutrient acquisition and immune evasion.

The findings strengthen the growing scientific interest in phytotherapeutics and point toward a future where plant-derived bioactive molecules could serve as safe, accessible and effective adjuncts to conventional periodontal therapy. Further in vitro and in vivo studies will be essential to confirm the translational potential, but the direction is highly promising for both clinicians and researchers.

🔗 Read more: https://dmp.umw.edu.pl/en/article/2025/62/5/883/

11/11/2025

🦷 Why esthetics should never outweigh biology: Veneers under the microscope

Porcelain veneers have become a mainstream “instant smile” solution, driven by social media aesthetics and patient demand. But recent research shows that placing esthetics above biology can lead to irreversible damage.

The authors highlight that the true success of veneers lies not in the final photo, but in enamel preservation, diagnosis and ethical clinical decisions. When preparation reaches dentin, failure rates increase dramatically. What makes veneers truly predictable is minimal intervention, guided planning, CAD/CAM precision, and fully informed consent. In younger patients or those with healthy tooth structure, less invasive options — orthodontics, whitening, or direct composite — should be prioritized.

The message is clear: veneers are a powerful solution, but not a default one. Ethical dentistry means choosing what is best for biology and long-term function—not what looks best on social media.

🔗 Read more: https://dmp.umw.edu.pl/en/article/2025/62/5/779/

04/11/2025

📢 New Section on the DMP Website

We are excited to announce the launch of a new “Guidelines, Consensus Statements, Clinical & Research Tools” tab on our website.

This section features key materials published in Dental and Medical Problems (DMP) — including guidelines, consensus statements, validated questionnaires, and expert recommendations.

All resources are published in open access, ensuring they are freely available to researchers, clinicians, and healthcare professionals worldwide.

🔗 Visit the section and stay up to date with new, evidence-based tools: https://dmp.umw.edu.pl/en/guidelines-statements-tools

28/10/2025

🔍 Alarming Gap in Oral Health Awareness Among Polish Adults

A newly published study has uncovered a critical public health concern: only 14.8% of adults exhibit adequate knowledge and behaviors related to oral hygiene. Despite increased access to dental care products and a growing awareness of healthy living, a significant proportion of adults lack understanding of essential preventive measures such as fluoride use, interdental cleaning and proper brushing techniques. Alarmingly, nearly 20% of respondents did not know whether their toothpaste contained fluoride, and many mistakenly believed fluoride to be harmful.

These findings underscore that access to products alone is not enough — education is the missing link. Dental professionals remain the most trusted source of knowledge, yet preventive counseling during visits is still insufficient.

Strengthening community-based education, integrating oral health into public health policy and promoting evidence-based messaging are crucial steps toward improving overall health outcomes and reducing the long-term costs associated with caries and periodontal disease. Oral health is not just a dental issue — it is a fundamental component of systemic health and quality of life.

🔗 Read more: https://dmp.umw.edu.pl/en/article/2025/62/4/569/

22/10/2025

🦷 Your next dental assistant might not wear scrubs: Artificial Intelligence in Endodontics

AI is no longer a futuristic concept—it's already transforming clinical decision-making in endodontics. What began in research labs is now entering everyday practice: interpreting radiographs, forecasting treatment outcomes, and supporting case evaluation with remarkable accuracy.

🔍 Key insights from over a decade of research:

• AI in endodontics emerged in 2012, with an explosive rise in publications starting in 2019.
• The United States leads the field, followed by Germany, China and India.
• Radiographs and CBCT imaging are the primary domains where AI is tested and applied.
• Convolutional neural networks (CNNs) can detect periapical lesions, evaluate complex canal morphology (including C-shaped canals), and accurately predict treatment success — often matching expert-level performance.

✨ Where the clinician’s vision ends, algorithms extend the view. AI can identify subtle radiographic changes that are invisible to the human eye, enabling earlier detection, higher precision, and less invasive patient care.

🔗 Read more: https://dmp.umw.edu.pl/en/article/2025/62/4/657/

🔊 Listen to the podcast:
https://soundcloud.com/wmu-pl/the-dentists-new-assistant-artificial-intelligence-in-endodontics?si=f701c42bde324915a0bb3e6eb1275bb5&utm_source=clipboard&utm_medium=text&utm_campaign=social_sharing

21/10/2025

🧠 New evidence linking gum disease and cognitive decline

A new study provides compelling evidence of a link between periodontal health and cognitive performance. Conducted at the Autonomous University of San Luis Potosí, Mexico, the research examined adults aged 55 and older using the Montreal Cognitive Assessment (MoCA). More than half of the participants showed signs of mild cognitive impairment (MCI), and those with severe gum inflammation or clinical attachment loss were significantly more likely to be affected.

The study highlights how chronic oral inflammation may contribute to neuroinflammatory processes involved in cognitive decline. It also reinforces the need for dental professionals to consider cognitive screening in older patients with periodontal disease and to promote preventive care that supports both oral and systemic health.

Healthy gums may do more than preserve your smile—they may help protect your mind.

🔗 Read more: https://dmp.umw.edu.pl/en/article/2025/62/4/591/

Address

Ulica K. Marcinkowskiego 2-6

50-368

Opening Hours

Monday	08:00 - 16:00
Tuesday	08:00 - 16:00
Wednesday	08:00 - 16:00
Thursday	08:00 - 16:00
Friday	08:00 - 16:00

Website

https://www.dmp.umed.wroc.pl/en/home/

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