25/03/2026
Diffuse gliomas with IDH mutations represent a major subgroup of brain tumors in adults. This review presents the molecular basis of these tumors and clinical evidence on vorasidenib, the first IDH1/2 inhibitor. Results from the INDIGO study showed prolonged progression-free survival, slower tumor growth, and delayed need for further treatment, while real-world data confirmed the activity and tolerability of vorasidenib in a broader patient population.
Authors: Tomasz Kubiatowski, Ewa Iżycka-Świeszewska