15/04/2021
A 48-year-old White woman with an unremarkable medical history presented to the emergency department with a 3-day history of malaise and abdominal pain. The initial evaluation at another hospital showed mild anemia and severe thrombocytopenia (platelet count, 13,000 per cubic millimeter [reference range, 150,000 to 400,000]).
A peripheral-blood smear confirmed a marked reduction in the platelet count with occasional schistocytes. Additional studies showed a low fibrinogen level (89 mg per deciliter [reference range, 220 to 397]), a prolonged activated partial thromboplastin time (41 seconds [reference range, 25 to 37]), and a marked elevation in the d-dimer level (117.5 mg per liter [reference value,
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.