02/28/2026
What is the difference between “opioid tolerance,” “opioid dependence,” and “opioid use disorder”?
Opioid tolerance occurs when a person using opioids begins to experience a reduced response to medication, requiring more opioids to experience the same effect.
Opioid dependence occurs when the body adjusts its normal functioning around regular opioid use. Unpleasant physical symptoms occur when opioids are stopped.
Opioid use disorder (OUD) is a problematic pattern of opioid use that causes significant impairment or distress (CDC).
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