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Join Dr. Christopher Carraway in this free webinar as he provides a practical, in-depth look at the Priority Principles ...
02/14/2026

Join Dr. Christopher Carraway in this free webinar as he provides a practical, in-depth look at the Priority Principles and how to apply them seamlessly in clinical practice.
Key Talking Points Include:
> The evolution of photobiomodulation therapy, including advances in emitters, power outputs, and treatment protocols
> Introduction to the Priority Principles as an advanced, evidence-informed framework for treatment planning
> Efficient use of multiple emitters to achieve varied biological effects and improve case management
> Strategies for adapting protocols in complex or challenging cases to maintain therapeutic progress

Register Here: https://attendee.gotowebinar.com/register/4690484071567807575?source=social

๐€ ๐ซ๐š๐ง๐๐จ๐ฆ๐ข๐ณ๐ž๐ ๐œ๐จ๐ง๐ญ๐ซ๐จ๐ฅ๐ฅ๐ž๐ ๐ญ๐ซ๐ข๐š๐ฅ ๐จ๐ง ๐ญ๐ก๐ž ๐ž๐Ÿ๐Ÿ๐ž๐œ๐ญ๐ข๐ฏ๐ž๐ง๐ž๐ฌ๐ฌ ๐จ๐Ÿ ๐ฅ๐จ๐ฐ-๐ฅ๐ž๐ฏ๐ž๐ฅ ๐ฅ๐š๐ฌ๐ž๐ซ ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ ๐ฏ๐ž๐ซ๐ฌ๐ฎ๐ฌ ๐ฉ๐š๐ซ๐š๐œ๐ž๐ญ๐š๐ฆ๐จ๐ฅ-๐œ๐š๐Ÿ๐Ÿ๐ž๐ข๐ง๐ž ๐Ÿ๐จ๐ซ ๐ฉ๐š๐ข๐ง ๐œ๐จ๐ง๐ญ๐ซ...
02/13/2026

๐€ ๐ซ๐š๐ง๐๐จ๐ฆ๐ข๐ณ๐ž๐ ๐œ๐จ๐ง๐ญ๐ซ๐จ๐ฅ๐ฅ๐ž๐ ๐ญ๐ซ๐ข๐š๐ฅ ๐จ๐ง ๐ญ๐ก๐ž ๐ž๐Ÿ๐Ÿ๐ž๐œ๐ญ๐ข๐ฏ๐ž๐ง๐ž๐ฌ๐ฌ ๐จ๐Ÿ ๐ฅ๐จ๐ฐ-๐ฅ๐ž๐ฏ๐ž๐ฅ ๐ฅ๐š๐ฌ๐ž๐ซ ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ ๐ฏ๐ž๐ซ๐ฌ๐ฎ๐ฌ ๐ฉ๐š๐ซ๐š๐œ๐ž๐ญ๐š๐ฆ๐จ๐ฅ-๐œ๐š๐Ÿ๐Ÿ๐ž๐ข๐ง๐ž ๐Ÿ๐จ๐ซ ๐ฉ๐š๐ข๐ง ๐œ๐จ๐ง๐ญ๐ซ๐จ๐ฅ ๐๐ฎ๐ซ๐ข๐ง๐  ๐จ๐ฏ๐ž๐ซ๐š๐ฅ๐ฅ ๐จ๐ซ๐ญ๐ก๐จ๐๐จ๐ง๐ญ๐ข๐œ ๐ญ๐ซ๐ž๐š๐ญ๐ฆ๐ž๐ง๐ญ
Amer Maher Owayda, et al

This study aimed to evaluate the analgesic effects of low-level laser therapy (LLLT) and paracetamol-caffeine in controlling orthodontic pain induced during different stages of leveling and alignment orthodontic treatment. Fifty-four patients with mild to moderate crowded arches were enrolled. [...] The first group received a beam of GaAlAs-Laser before separator placement or any archwire replacement, whereas the second group received paracetamol-caffeine tablets (the drug). Patients in the control group did not receive any procedure. A numeric rating scale (NRS) was used to assess spontaneous and chewing pain immediately, after 1, 24, 48 h, one week, and on the next visit of any replacement. The pain perception reached its peak after 24 h of any replacement. The intensity of pain after 24 and 48 h of separatorsโ€™ placement and initial archwiresโ€™ engagement was significantly greater than pain induced by 0.016, 0.016 ร— 0.022, 0.017 ร— 0.025, and 0.019 ร— 0.025 NiTi and 0.019 ร— 0.025 SS archwires in all groups for spontaneous and chewing pain scores. Pain scores in the LLLT group were significantly smaller than those of the control group after 48 h of separation and after 24 and 48 h of rectangular archwire insertion. No significant differences were observed between the drug and control groups. The highest pain levels were induced during the initial stages (separation and initial archwire) of orthodontic treatment. LLLT was able to reduce the peak of high-level pain just during separation and was not highly effective throughout the treatment course. On the other hand, the paracetamol-caffeine combination was not very effective in reducing pain perception throughout the treatment course.

https://www.nature.com/articles/s41598-025-16658-2

๐„๐Ÿ๐Ÿ๐ž๐œ๐ญ ๐จ๐Ÿ ๐ฅ๐จ๐ฐ-๐ฅ๐ž๐ฏ๐ž๐ฅ ๐ฅ๐š๐ฌ๐ž๐ซ ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ (๐‹๐‹๐‹๐“) ๐จ๐ง ๐œ๐จ๐ ๐ง๐ข๐ญ๐ข๐ฏ๐ž ๐ข๐ฆ๐ฉ๐š๐ข๐ซ๐ฆ๐ž๐ง๐ญ ๐š๐ฆ๐จ๐ง๐  ๐ฉ๐š๐ญ๐ข๐ž๐ง๐ญ๐ฌ ๐ฐ๐ข๐ญ๐ก ๐œ๐ก๐ซ๐จ๐ง๐ข๐œ ๐ฌ๐œ๐ก๐ข๐ณ๐จ๐ฉ๐ก๐ซ๐ž๐ง๐ข๐š: ๐š ๐๐จ๐ฎ๐›๐ฅ๐ž-๐›๐ฅ๐ข...
02/12/2026

๐„๐Ÿ๐Ÿ๐ž๐œ๐ญ ๐จ๐Ÿ ๐ฅ๐จ๐ฐ-๐ฅ๐ž๐ฏ๐ž๐ฅ ๐ฅ๐š๐ฌ๐ž๐ซ ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ (๐‹๐‹๐‹๐“) ๐จ๐ง ๐œ๐จ๐ ๐ง๐ข๐ญ๐ข๐ฏ๐ž ๐ข๐ฆ๐ฉ๐š๐ข๐ซ๐ฆ๐ž๐ง๐ญ ๐š๐ฆ๐จ๐ง๐  ๐ฉ๐š๐ญ๐ข๐ž๐ง๐ญ๐ฌ ๐ฐ๐ข๐ญ๐ก ๐œ๐ก๐ซ๐จ๐ง๐ข๐œ ๐ฌ๐œ๐ก๐ข๐ณ๐จ๐ฉ๐ก๐ซ๐ž๐ง๐ข๐š: ๐š ๐๐จ๐ฎ๐›๐ฅ๐ž-๐›๐ฅ๐ข๐ง๐ ๐ซ๐š๐ง๐๐จ๐ฆ๐ข๐ณ๐ž๐ ๐ฉ๐ฅ๐š๐œ๐ž๐›๐จ-๐œ๐จ๐ง๐ญ๐ซ๐จ๐ฅ๐ฅ๐ž๐ ๐œ๐ฅ๐ข๐ง๐ข๐œ๐š๐ฅ ๐ญ๐ซ๐ข๐š๐ฅ
Ali Kheradmand, et al

Low-level laser therapy (LLLT) is a noninvasive technique used in different medical fields. It has been applied in different medical areas such as wound healing, traumatic brain injuries, neurological disorders, cognitive disorders, Alzheimerโ€™s disease, pain, and arthritis, with different results. We studied the effectiveness of LLLT on cognitive impairment in patients with chronic schizophrenia. A randomized controlled double-blind clinical trial was performed in a menโ€™s chronic treatment center, in Razi Psychiatric Hospital, in Tehran, Iran. We screened the cognitive impairment by Mini-Mental State Examination (MMSE). Positive And Negative Syndrome Scale (PANSS) was also used to assess the patientsโ€™ positive and negative symptoms. Seventeen consenting patients were randomly allocated to the treatment arm, and 15 to the sham treatment control arm. The mean age of the control and treated patients was 49.47 ยฑ 6.99 and 50.24 ยฑ 7.69, respectively. No significant difference in PANSS and MMSE test scores was detected in both groups after the 6th session and after 2 months of follow-up after laser therapy. The positive and negative scales and agitation and excitement levels did not change significantly in either group. Nevertheless, the depression/anxiety subscale in the PANSS test showed a significant reduction after 6 sessions but did not persist after 2 months. No improvement in cognitive impairment or the positive and negative symptoms was detected after LLLT in patients with chronic schizophrenia. Trial registration: IRCT 20210520051349N1.

https://link.springer.com/article/10.1007/s10103-022-03545-9

๐“๐ก๐ž ๐ž๐Ÿ๐Ÿ๐ž๐œ๐ญ๐ฌ ๐จ๐Ÿ ๐ฅ๐จ๐ฐ-๐ฅ๐ž๐ฏ๐ž๐ฅ ๐ฅ๐š๐ฌ๐ž๐ซ ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ ๐จ๐ง ๐ฆ๐ฎ๐ฌ๐œ๐ฅ๐ž ๐ฌ๐ญ๐ซ๐ž๐ง๐ ๐ญ๐ก ๐š๐ง๐ ๐Ÿ๐ฎ๐ง๐œ๐ญ๐ข๐จ๐ง๐š๐ฅ ๐จ๐ฎ๐ญ๐œ๐จ๐ฆ๐ž๐ฌ ๐ข๐ง ๐ข๐ง๐๐ข๐ฏ๐ข๐๐ฎ๐š๐ฅ๐ฌ ๐ฐ๐ข๐ญ๐ก ๐ค๐ง๐ž๐ž ๐จ๐ฌ๐ญ๐ž๐จ๐š๐ซ๐ญ๐ก๐ซ๐ข๐ญ๐ข...
02/11/2026

๐“๐ก๐ž ๐ž๐Ÿ๐Ÿ๐ž๐œ๐ญ๐ฌ ๐จ๐Ÿ ๐ฅ๐จ๐ฐ-๐ฅ๐ž๐ฏ๐ž๐ฅ ๐ฅ๐š๐ฌ๐ž๐ซ ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ ๐จ๐ง ๐ฆ๐ฎ๐ฌ๐œ๐ฅ๐ž ๐ฌ๐ญ๐ซ๐ž๐ง๐ ๐ญ๐ก ๐š๐ง๐ ๐Ÿ๐ฎ๐ง๐œ๐ญ๐ข๐จ๐ง๐š๐ฅ ๐จ๐ฎ๐ญ๐œ๐จ๐ฆ๐ž๐ฌ ๐ข๐ง ๐ข๐ง๐๐ข๐ฏ๐ข๐๐ฎ๐š๐ฅ๐ฌ ๐ฐ๐ข๐ญ๐ก ๐ค๐ง๐ž๐ž ๐จ๐ฌ๐ญ๐ž๐จ๐š๐ซ๐ญ๐ก๐ซ๐ข๐ญ๐ข๐ฌ: ๐š ๐๐จ๐ฎ๐›๐ฅ๐ž-๐›๐ฅ๐ข๐ง๐๐ž๐ ๐ซ๐š๐ง๐๐จ๐ฆ๐ข๐ณ๐ž๐ ๐œ๐จ๐ง๐ญ๐ซ๐จ๐ฅ๐ฅ๐ž๐ ๐ญ๐ซ๐ข๐š๐ฅ
Amornthep Jankaew, et al

The purpose of this study was to compare the therapeutic effects of low-level laser therapy (LLLT) with 808 and 660 nm wavelength on muscle strength and functional outcomes in individuals with knee osteoarthritis (OA). A total of 47 participants were randomly assigned to the 808 nm, 660 nm, and sham control groups. Two LLLT groups received continuous LLLT with a mean power of 300 mW in different wavelengths at the knee joint 15 min a session three days per week for eight weeks, while the control group received the sham LED treatment. The knee strength and functional performance involving 30-s sit-to-stand, 40 m fast-paced walk, stair climbing, and the TUG test were measured at the baseline and one week after the interventions were completed. The results showed that knee extensor strength was more improved in the 808 nm group as compared to the 660 nm group (p < 0.001, d = 0.57) and the sham control (p < 0.001, d = 0.40), while increased flexor strength was demonstrated in the 808 nm (p = 0.009, d = 0.67) and sham control groups (p < 0.001, d = 0.97). The number of 30-s sit-to-stand was increased only in the 660 nm group (p = 0.006, d = 0.49). All three groups exhibited improvements in the other three functional performance-based tests after the interventions with no statistically significant differences among the groups. In conclusion, both intervention groups improved muscle strength and functional performance as compared to the control group. The 808 nm wavelength group showed better results in knee extensor strength. Therefore, laser therapy is suggested to be integrated into rehabilitation programs to improve muscle strength and functional performance in the population with knee OA.

https://www.nature.com/articles/s41598-022-26553-9

๐„๐Ÿ๐Ÿ๐ข๐œ๐š๐œ๐ฒ ๐จ๐Ÿ ๐ฅ๐จ๐ฐ-๐ฅ๐ž๐ฏ๐ž๐ฅ ๐ฅ๐š๐ฌ๐ž๐ซ ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ ๐ข๐ง ๐ฉ๐š๐ญ๐ข๐ž๐ง๐ญ๐ฌ ๐ฐ๐ข๐ญ๐ก ๐ฅ๐จ๐ฐ๐ž๐ซ ๐ž๐ฑ๐ญ๐ซ๐ž๐ฆ๐ข๐ญ๐ฒ ๐ญ๐ž๐ง๐๐ข๐ง๐จ๐ฉ๐š๐ญ๐ก๐ฒ ๐จ๐ซ ๐ฉ๐ฅ๐š๐ง๐ญ๐š๐ซ ๐Ÿ๐š๐ฌ๐œ๐ข๐ข๐ญ๐ข๐ฌ: ๐ฌ๐ฒ๐ฌ๐ญ๐ž๐ฆ๐š๐ญ๐ข๐œ ๐ซ๐ž๐ฏ๐ข๐ž...
02/10/2026

๐„๐Ÿ๐Ÿ๐ข๐œ๐š๐œ๐ฒ ๐จ๐Ÿ ๐ฅ๐จ๐ฐ-๐ฅ๐ž๐ฏ๐ž๐ฅ ๐ฅ๐š๐ฌ๐ž๐ซ ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ ๐ข๐ง ๐ฉ๐š๐ญ๐ข๐ž๐ง๐ญ๐ฌ ๐ฐ๐ข๐ญ๐ก ๐ฅ๐จ๐ฐ๐ž๐ซ ๐ž๐ฑ๐ญ๐ซ๐ž๐ฆ๐ข๐ญ๐ฒ ๐ญ๐ž๐ง๐๐ข๐ง๐จ๐ฉ๐š๐ญ๐ก๐ฒ ๐จ๐ซ ๐ฉ๐ฅ๐š๐ง๐ญ๐š๐ซ ๐Ÿ๐š๐ฌ๐œ๐ข๐ข๐ญ๐ข๐ฌ: ๐ฌ๐ฒ๐ฌ๐ญ๐ž๐ฆ๐š๐ญ๐ข๐œ ๐ซ๐ž๐ฏ๐ข๐ž๐ฐ ๐š๐ง๐ ๐ฆ๐ž๐ญ๐š-๐š๐ง๐š๐ฅ๐ฒ๐ฌ๐ข๐ฌ ๐จ๐Ÿ ๐ซ๐š๐ง๐๐จ๐ฆ๐ข๐ฌ๐ž๐ ๐œ๐จ๐ง๐ญ๐ซ๐จ๐ฅ๐ฅ๐ž๐ ๐ญ๐ซ๐ข๐š๐ฅ๐ฌ
Ingvill Fjell Naterstad, et al

Objectives We investigated the effectiveness of low-level laser therapy (LLLT) in lower extremity tendinopathy and plantar fasciitis on patient-reported pain and disability.
[...]
Results: LLLT was compared with placebo (10 trials), other interventions (5 trials) and as an add-on intervention (3 trials). The study quality was moderate to high.

Overall, pain was significantly reduced by LLLT at completed therapy (13.15 mm Visual Analogue Scale (VAS; 95% CI 7.82 to 18.48)) and 4โ€“12 weeks later (12.56 mm VAS (95% CI 5.69 to 19.42)). Overall, disability was significantly reduced by LLLT at completed therapy (Standardised Mean Difference (SMD)=0.39 (95% CI 0.09 to 0.7) and 4โ€“9 weeks later (SMD=0.32 (95% CI 0.05 to 0.59)). Compared with placebo control, the recommended doses significantly reduced pain at completed therapy (14.98 mm VAS (95% CI 3.74 to 26.22)) and 4โ€“8 weeks later (14.00 mm VAS (95% CI 2.81 to 25.19)). The recommended doses significantly reduced pain as an add-on to exercise therapy versus exercise therapy alone at completed therapy (18.15 mm VAS (95% CI 10.55 to 25.76)) and 4โ€“9 weeks later (15.90 mm VAS (95% CI 2.3 to 29.51)). No adverse events were reported.

Conclusion: LLLT significantly reduces pain and disability in lower extremity tendinopathy and plantar fasciitis in the short and medium term. Long-term data were not available. Some uncertainty about the effect size remains due to wide CIs and lack of large trials.
https://bmjopen.bmj.com/content/bmjopen/12/9/e059479.full.pdf

๐“๐ก๐ž ๐…๐ฎ๐ง๐œ๐ญ๐ข๐จ๐ง๐ฌ ๐š๐ง๐ ๐Œ๐ž๐œ๐ก๐š๐ง๐ข๐ฌ๐ฆ๐ฌ ๐จ๐Ÿ ๐‹๐จ๐ฐ-๐‹๐ž๐ฏ๐ž๐ฅ ๐‹๐š๐ฌ๐ž๐ซ ๐“๐ก๐ž๐ซ๐š๐ฉ๐ฒ ๐ข๐ง ๐“๐ž๐ง๐๐จ๐ง ๐‘๐ž๐ฉ๐š๐ข๐ซ (๐‘๐ž๐ฏ๐ข๐ž๐ฐ)Kexin Lyu, et alTendon injury is a comm...
02/09/2026

๐“๐ก๐ž ๐…๐ฎ๐ง๐œ๐ญ๐ข๐จ๐ง๐ฌ ๐š๐ง๐ ๐Œ๐ž๐œ๐ก๐š๐ง๐ข๐ฌ๐ฆ๐ฌ ๐จ๐Ÿ ๐‹๐จ๐ฐ-๐‹๐ž๐ฏ๐ž๐ฅ ๐‹๐š๐ฌ๐ž๐ซ ๐“๐ก๐ž๐ซ๐š๐ฉ๐ฒ ๐ข๐ง ๐“๐ž๐ง๐๐จ๐ง ๐‘๐ž๐ฉ๐š๐ข๐ซ (๐‘๐ž๐ฏ๐ข๐ž๐ฐ)
Kexin Lyu, et al

Tendon injury is a common disease of the musculoskeletal system, accounting for roughly 30%โ€“40% of sports system disorder injuries. In recent years, its incidence is increasing. Many studies have shown that low-level laser therapy (LLLT) has a significant effect on tendon repair by firstly activating cytochrome C oxidase and thus carrying out the photon absorption process, secondly acting in all the three phases of tendon repair, and finally improving tendon recovery. The repair mechanisms of LLLT are different in the three phases of tendon repair. In the inflammatory phase, LLLT mainly activates a large number of VEGF and promotes angiogenesis under hypoxia. During the proliferation phase, LLLT increases the amount of collagen type III by promoting the proliferation of fibroblasts. Throughout the remodeling phase, LLLT mainly activates M2 macrophages and downregulates inflammatory factors, thus reducing inflammatory responses. However, it should also be noted that in the final phase of tendon repair, the use of LLLT causes excessive upregulation of some growth factors, which will lead to tendon fibrosis. In summary, we need to further investigate the functions and mechanisms of LLLT in the treatment of tendon injury and to clarify the nature of LLLT for the treatment of diverse tendon injury diseases.

https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.808374/full

Join Dr. Christopher Carraway in this free webinar as he provides a practical, in-depth look at the Priority Principles ...
02/08/2026

Join Dr. Christopher Carraway in this free webinar as he provides a practical, in-depth look at the Priority Principles and how to apply them seamlessly in clinical practice. Attendees will learn about case progression and decision-making, including how and when to modify treatment direction mid-course in response to challenging or non-responsive cases. Additionally, Dr. Carraway will also explore strategic use of multiple emitters, including how to blend them to achieve specific therapeutic effects and optimize clinical outcomes.

Key Talking Points Include:
> The evolution of photobiomodulation therapy, including advances in emitters, power outputs, and treatment protocols
> Introduction to the Priority Principles as an advanced, evidence-informed framework for treatment planning
> Efficient use of multiple emitters to achieve varied biological effects and improve case management
> Strategies for adapting protocols in complex or challenging cases to maintain therapeutic progress

Register Here: https://attendee.gotowebinar.com/register/4690484071567807575?source=social

The Priority Principle is a well-studied methodology for applying photobiomodulation therapy based on the current sympto...
02/06/2026

The Priority Principle is a well-studied methodology for applying photobiomodulation therapy based on the current symptoms of the patient. The order in which a patientโ€™s pain, swelling, and inflammation are addressed matters - and the Priority Principleโ€™s dynamic framework allows physicians to customize their own protocols and treatment regimens, rather than relying on a more rigid โ€œcookie-cutterโ€ protocol.

Join Dr. Christopher Carraway in this free webinar as he provides a practical, in-depth look at the Priority Principles and how to apply them seamlessly in clinical practice. Attendees will learn about case progression and decision-making, including how and when to modify treatment direction mid-course in response to challenging or non-responsive cases. Additionally, Dr. Carraway will also explore strategic use of multiple emitters, including how to blend them to achieve specific therapeutic effects and optimize clinical outcomes.

Key Talking Points Include:
> The evolution of photobiomodulation therapy, including advances in emitters, power outputs, and treatment protocols
> Introduction to the Priority Principles as an advanced, evidence-informed framework for treatment planning
> Efficient use of multiple emitters to achieve varied biological effects and improve case management
> Strategies for adapting protocols in complex or challenging cases to maintain therapeutic progress

Register Here: https://attendee.gotowebinar.com/register/4690484071567807575?source=social

๐๐ก๐จ๐ญ๐จ๐›๐ข๐จ๐ฆ๐จ๐๐ฎ๐ฅ๐š๐ญ๐ข๐จ๐ง ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ ๐ข๐ง ๐ฆ๐จ๐จ๐ ๐๐ข๐ฌ๐จ๐ซ๐๐ž๐ซ๐ฌ: ๐š ๐ฌ๐ฒ๐ฌ๐ญ๐ž๐ฆ๐š๐ญ๐ข๐œ ๐ซ๐ž๐ฏ๐ข๐ž๐ฐKatayoon Montazeri, et alMood disorders are common, deb...
02/03/2026

๐๐ก๐จ๐ญ๐จ๐›๐ข๐จ๐ฆ๐จ๐๐ฎ๐ฅ๐š๐ญ๐ข๐จ๐ง ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ ๐ข๐ง ๐ฆ๐จ๐จ๐ ๐๐ข๐ฌ๐จ๐ซ๐๐ž๐ซ๐ฌ: ๐š ๐ฌ๐ฒ๐ฌ๐ญ๐ž๐ฆ๐š๐ญ๐ข๐œ ๐ซ๐ž๐ฏ๐ข๐ž๐ฐ
Katayoon Montazeri, et al

Mood disorders are common, debilitating and impose a high-cost burden on society. Side effects and resistance to psychiatric drugs justify finding new treatment methods. Photobiomodulation therapy (PBMT) uses photons of light to repair, modulate and improve the function of target tissue. The purpose of this study is to systematically review the use of PBMT for the treatment of mood disorders and to identify the useful parameters of PBMT, the level of evidence of its effectiveness, and the degree of its practical recommendation. โ€œGoogle scholar,โ€ โ€œPub Med,โ€ โ€œScopus,โ€ and โ€œScience directโ€ online databases were searched based on Preferred Reporting Items for Systematic Reviews and meta-analyses (PRISMA) guidelines. The human or animal studies written in English and published from January 2009 to August 2021 were included. Sixteen studies, which included four randomized controlled trials (RCTs), met the inclusion criteria. Infrared wavelength ranges from 800 to 830 nm, power density of 250 mW/cm2 and energy density of 60 to 120 J/ cm2 were the most used PBMT parameters. Bias risk assessment was performed to evaluate the quality of RCTs in which 2 out of 4 RCTs were evaluated as high quality. Based on grade practice recommendations, PBMT can be classified as strongly recommended for moderate grade of major depressive disorder (MDD) and recommended for anxiety disorder. In bipolar disorder, further studies are needed to recommend this therapeutic method.

https://link.springer.com/article/10.1007/s10103-022-03641-w

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