03/12/2026
Understanding Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but life-threatening skin conditions that cause severe inflammation, redness, and peeling of the skin. These disorders are closely related and are mainly distinguished by the percentage of total body surface area (TBSA) affected.
▪ SJS: affects less than 10% of the body
▪ TEN: affects more than 30% of the body
▪ SJS/TEN overlap: involves 10–30% of the body
These conditions are most often triggered by reactions to medications, including certain antibiotics like sulfa drugs and some anti-seizure medications. Each patient’s experience can vary greatly depending on severity and complications.
Because SJS and TEN damage the protective barrier of the skin, patients become highly vulnerable to infection, fluid loss, and multi-organ complications. In severe cases, the body undergoes extensive skin loss similar to major burns.
Treatment often requires specialized care in a multidisciplinary burn center where experts can manage complex wound care, prevent infection, and support organ function. Some patients may require skin graft procedures, while others may need ventilator support to protect the airway.
Early recognition and immediate specialized care are critical for improving outcomes.
Dr. Travis Perry, MD, The Burn and Wound Dr., and the team at JMS Burn Center at Wellstar Cobb provide specialized treatment for complex skin injuries and severe conditions like SJS and TEN.