MBX Biosciences, Inc.

MBX Biosciences, Inc. At MBX Biosciences, our mission is to help people with endocrine and metabolic disorders live fuller and healthier lives. MBX is based in Carmel, Indiana.

We’re pioneering a pipeline of novel Precision Endocrine Peptides (PEPs) with clinically validated targets, established endpoints for regulatory approval, targeting significant unmet medical needs and large potential market opportunities. Our lead product candidate canvuparatide (MBX 2109), is in Phase 2 development for the treatment of chronic hypoparathyroidism (HP); MBX 1416, has recently completed a Phase 1 trial and is in development for the treatment of post-bariatric hypoglycemia (PBH); and we also are developing an obesity portfolio that includes MBX 4291, as well as multiple discovery and pre-clinical candidates in development. To learn more, please visit the Company website at www.mbxbio.com.

During MBX’s recent Together Week, we had the privilege of welcoming back Andrea Ligler — a powerful voice in the Hypopa...
10/24/2025

During MBX’s recent Together Week, we had the privilege of welcoming back Andrea Ligler — a powerful voice in the Hypoparathyroidism (HP) community and a patient advocate whose story continues to inspire. Andrea offered a deeply personal update on her journey with HP, sharing not only the medical realities but also the daily challenges and triumphs that come with managing this rare condition.

At MBX, our team understands the burden of HP — but it’s through courageous storytellers like Andrea that these lessons come to life. Her lived experience reminds us that behind every diagnosis is a person, a family, and a future shaped by resilience and hope. We remain steadfast in our mission to amplify patient voices and help people with endocrine and metabolic disorders live fuller and healthier lives.

Stories like Andrea’s don’t just inform us — they move us to act with greater empathy, urgency, and purpose.

We’d like to thank everyone who joined us for our presentation, as well as express our gratitude to the HypoPARAthyroidi...
10/15/2025

We’d like to thank everyone who joined us for our presentation, as well as express our gratitude to the HypoPARAthyroidism Association, Inc. for hosting a fantastic event this past weekend!

It is especially meaningful to see such strong engagement from the hypoparathyroidism patient community – the conversations and questions throughout the event reflected a shared optimism about the future of the HP treatment landscape.

09/22/2025

Hopeful news for people living with : The Phase 2 Avail clinical trial of our once-weekly parathyroid hormone (PTH) replacement therapy met its primary endpoint with a 63% responder rate at 12-weeks, and 79% responder rate in the open-label extension. The candidate was generally well-tolerated, and the findings are an important step forward in research for this rare and chronic condition.

We are so thankful to the patients, families, doctors, and research teams who made this study possible. Your dedication brings us closer to simpler, more effective care options.

Learn more about the data and next steps for the investigational once-weekly PTH replacement therapy: https://investors.mbxbio.com/news-releases/news-release-details/mbx-biosciences-announces-once-weekly-canvuparatide-achieved

09/04/2025

We announced today that the first participant has been dosed in the Phase 1 trial of our Precision Endocrine Peptide (PEP) glucagon-like peptide-1 (GLP-1)/ glucose-dependent insulinotropic polypeptide (GIP) co-agonist prodrug for the treatment of .

Thank you to our talented team, whose dedication to improving the lives of patients affected by obesity brought this milestone to fruition.

Read the press release here: https://investors.mbxbio.com/news-releases/news-release-details/mbx-biosciences-doses-first-participant-phase-1-trial-mbx-4291

During MBX’s latest Together Week, we were honored to host a fireside chat with Liz, who openly and honestly shared her ...
06/20/2025

During MBX’s latest Together Week, we were honored to host a fireside chat with Liz, who openly and honestly shared her journey with . Her story was a powerful reminder of the real people who can benefit from our platform — and the importance of listening to patient voices.

This conversation, along with others from patients with , deepens our understanding and drives our commitment to developing meaningful therapies.

At MBX Biosciences, we’re dedicated to improving the lives of those with and disorders. Hearing directly from patients inspires us to push forward, innovate with purpose, and never lose sight of who is at the center of our mission.

This afternoon, our CEO & Co-Founder, Kent Hawryluk, will discuss the IPO process and what companies can expect after go...
06/03/2025

This afternoon, our CEO & Co-Founder, Kent Hawryluk, will discuss the IPO process and what companies can expect after going public on a panel at the Global Entrepreneurship Congress Indiana 2025.

Learn more about the session and event: https://www.genglobal.org/gec/unlocking-ipo

Global Entrepreneurship Network

06/02/2025

We’re honored to partner alongside the HypoPARAthyroidism Association, Inc., in our shared goal to improve the lives of those with .

Hear from the hypoparathyroidism patient community about the importance of education and resources, the patient experience, and hope for others diagnosed with this condition.

06/01/2025

MBX stands with the community, especially on World Hypoparathyroidism Awareness Day, as we honor the strength, resilience, and daily experiences of those living with this rare and complex condition.

We are inspired by patients’ stories and remain deeply committed to ensuring their voices are heard. Through close collaboration with the medical and advocacy communities and a steadfast focus on advancing new treatment options, we strive to bring hope and meaningful change to those affected.

Hypoparathyroidism is a rare disorder in which the parathyroid glands, or lack thereof, produce insufficient amounts o...
05/29/2025

Hypoparathyroidism is a rare disorder in which the parathyroid glands, or lack thereof, produce insufficient amounts of parathyroid hormone (PTH), leading to low calcium levels and impacting many aspects of patients’ daily lives.

At MBX, we are committed to addressing the unmet needs of patients with . We are proud to work with the HypoPARAthyroidism Association, Inc. to raise awareness and ensure patient voices are heard as we advance our potential new medicine forward for patients.

Together, we aim to bring hope and meaningful change to the lives of those impacted by this condition. Follow along for more from MBX as we recognize Hypoparathyroidism Awareness Day on June 1!

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