RETpositive

RETpositive 501(c)(3) Nonprofit funding research and supporting all those affected by RET positive cancer

Lori () was diagnosed with Stage IV RET-positive lung cancer in July 2022, but because of cancer research she’s soaking ...
04/21/2026

Lori () was diagnosed with Stage IV RET-positive lung cancer in July 2022, but because of cancer research she’s soaking up the sun on the water with her husband of 26 years! Lori is on targeted therapy and has had “great results so far.” Thank you for sharing your story, Lori!

100% of donations to RETpositive go directly to funding research grantees. Learn more about the research RETpositive & our partners have funded to-date: https://www.retpositive.org/pages/funded-research

What happens when RET inhibitors stop working? RETpositive and The Happy Lungs Project  helped launch an international c...
04/17/2026

What happens when RET inhibitors stop working? RETpositive and The Happy Lungs Project helped launch an international consortium called the RETgistry to answer that question. Swipe through to see the findings!

Waliany S, et al. Landscape of Genomic Mechanisms of Resistance to Selective RET Inhibitors in RET-Altered Solid Tumors: Analysis of the RETgistry Global Consortium. Clinical Cancer Research (March 16, 2026)

100% of donations to RETpositive go directly to funding research grantees. Learn more about the research RETpositive & our partners have funded to-date: https://www.retpositive.org/pages/funded-research

Jenny was diagnosed with RET-positive thyroid cancer in 2016, but because of cancer research she’s still hitting the ski...
04/14/2026

Jenny was diagnosed with RET-positive thyroid cancer in 2016, but because of cancer research she’s still hitting the ski trails in Sweden. Thank you for sharing your story, Jenny!

100% of donations to RETpositive go directly to funding research grantees. Learn more about the research RETpositive & our partners have funded to-date: https://www.retpositive.org/pages/funded-research

04/11/2026

Happy National Pet Day from RETpositive! Meet some of the animal caregivers who make hard days a little softer.

100% of donations to RETpositive go directly to funding research grantees. Learn more about the research RETpositive & our partners have funded to-date: https://www.retpositive.org/pages/funded-research

Happy National Pet Day from RETpositive! Meet some of the animal caregivers who make hard days a little softer. Drop a p...
04/11/2026

Happy National Pet Day from RETpositive! Meet some of the animal caregivers who make hard days a little softer. Drop a photo of your pet in the comments — we want to see your caregivers too!

RET is best known in lung and thyroid cancer, but it can show up in colorectal cancer too. A new case report describes a...
04/10/2026

RET is best known in lung and thyroid cancer, but it can show up in colorectal cancer too. A new case report describes a stage IV colon cancer patient who was successfully treated with Retevmo. Read more here:

Trovato G, et al. “Molecular and Clinical Profile of a RET-Rearranged Colorectal Cancer With Prolonged Response to Platinum Therapy and Subsequent Targeted Treatment With Selpercatinib.” JCO Precision Oncology (2026) https://doi.org/10.1200/PO-25-00975

100% of donations to RETpositive go directly to funding research grantees. Learn more about the research RETpositive & our partners have funded to-date: https://www.retpositive.org/pages/funded-research

Our April Newsletter has updates on the landmark RETgistry study, our partnership with Lungevity, as well as links to ne...
04/08/2026

Our April Newsletter has updates on the landmark RETgistry study, our partnership with Lungevity, as well as links to new information about chemotherapy, biomarkers, and Retevmo for early-stage patients. Sign up at retpositive.org to subscribe!

 was diagnosed with Stage 4 RET-positive lung cancer in 2019, but because of cancer research she was able to celebrate h...
04/06/2026

was diagnosed with Stage 4 RET-positive lung cancer in 2019, but because of cancer research she was able to celebrate her husband's 50th birthday! Amy is one of the most encouraging, most consistent contributors to our RETpositive Facebook Group for patients and caregivers. Thank you Amy!!!

100% of donations to RETpositive go directly to funding research grantees. Learn more about the research RETpositive & our partners have funded to-date: https://www.retpositive.org/pages/funded-research

Happy Easter from the RETpositive community!
04/05/2026

Happy Easter from the RETpositive community!

The ARROW clinical trial has delivered its final data on Gavreto (pralsetinib) in RET-positive lung cancer: durable resp...
04/01/2026

The ARROW clinical trial has delivered its final data on Gavreto (pralsetinib) in RET-positive lung cancer: durable responses, manageable side effects, and especially promising results for first-line patients. Swipe through for our breakdown.

Besse B, et al. “Final Efficacy and Safety Data From the Phase I/II ARROW Study of Pralsetinib in Patients With Advanced RET Fusion–Positive Non–Small Cell Lung Cancer.” Journal of Clinical Oncology (March 26, 2026).
https://ascopubs.org/doi/10.1200/JCO-25-01489

100% of donations to RETpositive go directly to funding research grantees. Learn more about the research RETpositive & our partners have funded to-date: https://www.retpositive.org/pages/funded-research

Spain’s national cancer research center (CNIO  ) used electron microscopy and advanced molecular simulations to study a ...
03/31/2026

Spain’s national cancer research center (CNIO ) used electron microscopy and advanced molecular simulations to study a key driver in many RET-positive cancers. Read more about their intriguing results here:

Martín-Hurtado A, Plaza-Menacho I, et al. “The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase.” Nature Communications (2026)
https://www.nature.com/articles/s41467-026-69833-y

100% of donations to RETpositive go directly to funding research grantees. Learn more about the research RETpositive & our partners have funded to-date: https://www.retpositive.org/pages/funded-research

This Opening Day we’re tipping our caps to players like  and  who returned to   after cancer. They showed every cancer s...
03/26/2026

This Opening Day we’re tipping our caps to players like and who returned to after cancer. They showed every cancer survivor that the season isn’t over until it’s over. Let’s play ball!

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Chagrin Falls, OH

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