The Norris Lab

Advancing genetic, molecular, and clinical research for Ehlers-Danlos Syndrome and cardiovascular diseases.

03/31/2026

Happy endometriosis awareness month 💛

03/30/2026

Fatigue in Ehlers-Danlos syndromes can significantly impact daily functioning, yet it often goes ignored or minimized in clinical settings.

We are actively working on analyzing data from our global survey study surrounding rare types of EDS and their comorbidities! 🩺

03/27/2026

Join us for MIND 2026! 🧠

MUSC Institute for Neuroscience Discovery (MIND) hosts an annual conference in beautiful Charleston, SC 🌴 Each day will feature new and exciting topics, including craniotomies, spine procedures, pain management, EEG, and neuroscience education at both the national and international levels.

April 21st will feature a range of speakers focusing on the immune and neurological aspects of hypermobile Ehlers-Danlos syndrome, both clinically and scientifically.

Emphasizing lived patient experience alongside evidence-based, non-surgical strategies, the session will highlight the importance of coordinated, multidisciplinary care to improve function, autonomy, and long-term quality of life.

Register here today! mind2026.org

03/24/2026

Which one are you? 🌟🧐

Case Report — Introverted homebody that enjoys their own company. Cozy pajamas, ramen, Stardew Valley, and Netflix alone on a Friday. Has one very specific hyperfixation and will tell you everything about it.

Case Control — The fun, free spirit who does things their own way. Thrifted jeans, a banjo, a bike with a flower basket, and a van with no fixed plans. Marches to the beat of their own drum and somehow makes it work.

Cohort — The loyal one who’s been there since the beginning. Followed Taylor Swift through every era, still has their childhood best friends, and documents everything. Friendship bracelets, hiking trips, and a yearbook they actually kept. Rides with their people through every chapter, no matter how much everyone changes.

Cross-Sectional — The vintage soul who lives in the moment. Film camera, farmers market Saturdays, salt lamp glowing in the corner. Doesn’t need the whole story, one perfect snapshot is enough.

Randomized Control Trial — The overachiever who has a system for everything. Ice bath at 6am, AG1, a blazer for every occasion. Extremely structured, extremely consistent, and highly intimidating.

Systematic Review — The academic gremlin running on highlighters and Halloween candy. Seventeen browser tabs, a Tide-to-Go pen on their cardigan, always in the quiet study section. Will not form an opinion until they’ve read everything ever written on the subject.

03/23/2026

In light of recent misinformation about the biological underpinnings of hypermobile Ehlers-Danlos Syndrome, here’s a short breakdown of one of our recent publications: “Proteomic discoveries in hypermobile Ehlers–Danlos syndrome reveal insights into disease pathophysiology“ 🧬🥼👩🏻‍🔬

This study demonstrates immune system changes in people with hypermobile EDS compared to controls and discusses the ways in which these changes can impact different body systems impacted in this complex, multi-systemic disease.

03/20/2026

Complicated is a documentary seven years in the making, with a deeply important message. Directed by Andrew Abrahams, the film follows several young people living with Ehlers-Danlos Syndrome (EDS), a connective tissue disorder that, as one of the film’s subjects puts it, feels like being “built with Elmer’s glue instead of a hot glue gun.” Because collagen is one of tue body’s primary structural proteins, EDS can affect virtually every system in the body — joints, skin, blood vessels, and more.

But this film is about so much more than a diagnosis. It’s about the families who build walls of calm around themselves because collapse isn’t an option. It’s about the friendships forged between people whose lives are “too weird and complicated” for most of the world to understand. And it’s about a medical system that too often responds to complexity with suspicion — many of the families in the film faced allegations of medical child abuse at some point in their child’s journey.

Complicated is unflinching, necessary, and deeply human. If you or someone you love navigates chronic illness, complex disease, or a medical system that has ever made you feel blamed for being sick — this one’s for you.

Complicated is now available on Apple TV.

03/17/2026

Happy St. Pattys day! Play some unlucky bingo with us on your story! ☘️ comment how many you got!

03/17/2026

Besides hypermobile Ehlers-Danlos syndrome (and hypermobility spectrum disorders), the Ehlers-Danlos syndromes are rare diseases.

03/11/2026

Hypermobile Ehlers–Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSDs) are prevalent, complex conditions marked by chronic pain, joint instability, and multisystem involvement.

To ignore the realities that these patients face everyday is not only neglectful, but can even be life-threatening. We urge HealthNZ to listen to patients and create new guidance rooted in accurate, credible, and complete research.

Accurate research saves lives.

Swipe to learn more about our support for the EDS community in New Zealand and why it matters.

03/10/2026

Using de-identified genomic data provided by Sequencing.com, our team is conducting genome-wide analyses that we hope will identify genetic variants and pathways relevant to EDS and Dysautonomia. For more information about our research, visit thenorrislab.com.

03/02/2026

Some chronic conditions, including many forms of Ehlers-Danlos syndrome (EDS), are considered dynamic disabilities. In these conditions, symptom severity can fluctuate significantly over short periods of time. Functional capacity may vary from hour to hour or day to day, meaning an individual’s level of mobility, pain, fatigue, or autonomic stability is not static.

A person may appear well and fully engaged in one setting, yet experience substantial physical limitations shortly thereafter. They may move independently at one point and require mobility support later the same day. These fluctuations reflect the nature of the condition, not inconsistency, exaggeration, or recovery.

Importantly, observable functioning at a single point in time represents only a brief snapshot of a much more complex and variable clinical picture. Periods of relative stability do not negate the presence or severity of disease. So comments like “you don’t look sick” might actually be more harmful than helpful for someone navigating a dynamic disability.

In research, clinical care, and community settings, it is essential to recognize that invisibility does not equate to absence. When individuals report symptom burden or functional limitations, those reports should be taken seriously. Belief costs nothing.

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Charleston, SC

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http://thenorrislab.com/, https://pubmed.ncbi.nlm.nih.gov/41355466/, https://www.medrxiv.org/content/10.1101/2025.09.19.

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