03/11/2026
If you’re waking up at 3 a.m. with anxiety… read this.
So many women in their 40s tell me the same thing:
“My heart starts racing in the middle of the night.”
“I feel anxious over things that never used to bother me.”
“My sleep is suddenly terrible.”
And they’re told…
“It’s just stress.”
Yes, stress can play a role.
But during perimenopause, there is also a very real physiological shift happening.
Progesterone — the hormone that helps calm your brain and nervous system — is usually the first hormone to decline during this transition.
When progesterone drops:
Sleep becomes lighter
Cortisol hits harder
Your nervous system becomes more reactive
At the same time, fluctuating estrogen can impact serotonin, blood sugar stability, and mood regulation.
Add in poor sleep and everyday life stress, and suddenly your nervous system can feel like it’s stuck on high alert.
So if anxiety suddenly shows up in your 40s when you’ve never struggled with it before…
It may not be “just stress.”
Your body may simply be moving through a major hormonal transition that needs the right kind of support.
If you want help figuring out what’s actually going on in your body, you can book in the comments.
Comment HORMONES and I’ll share the top labs I run to uncover the root causes behind anxiety, sleep issues, and hormone shifts during perimenopause.