01/26/2026
“Normal labs” don’t always mean optimal physiology.
Estrogen is a key regulatory hormone with receptors in the brain, heart, bones, joints, muscle, and metabolic tissue. When levels decline during perimenopause and menopause, research shows measurable increases in insulin resistance, visceral fat, bone loss, cardiovascular risk, sleep disruption, mood changes, and cognitive symptoms.
These patterns are not random and they are not simply chronological aging. They reflect hormone signaling loss.
Ignoring that biology has led generations of women to normalize fatigue, brain fog, weight gain, anxiety, and pain.
The good news: evidence-based strategies, including lifestyle interventions and appropriately prescribed hormone therapy, can meaningfully improve health span and quality of life for many women.
If your body feels “off,” it deserves investigation, not dismissal.
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