11/11/2025
Hey everyone, Nurse Debi here. Hormones are in the news. The FDA has removed the black box warning for synthetic hormones potentially causing cancer. As I understand it, synthetic hormones are still associated with an increased risk of cancer, but hormone replacement therapy is associated with other benefits, such as reduced risk of dementia, cardiovascular disease, and/or bone fractures. The reason for removing the black box warning wasn't because the cancer risk isn't there, it's because women need help with the other things.
So what's a person to do? I only offer bio-identical hormones at our practice. Multiple studies have shown that soy does not increase the risk of cancer. Citation:
https://www.sciencedirect.com/science/article/pii/S2161831324001613
All this to say, we don't know what we don't know. But, so far the body of evidence showing the increased risk of cancer from of synthetic hormones, while phytoestrogen has not been shown to have the same risk; therefore, I choose to only offer bio-identical hormone replacement therapy at our clinic.
We do still recommend up-to-date mammogram and pap testing prior to starting any hormone replacement therapy.
Call us if you'd like to discuss it further. 865-340-6346