02/24/2026
📌 📌OPTIMAL PROTOCOL
There isn’t a one-size-fits-all “optimal protocol” for thyroid treatment, because it really depends on whether someone has a thyroid gland, how well they convert T4 to T3, other health issues, and how they respond to medication.
For many, starting with a good quality T4 replacement (like levothyroxine, or Tirosint) works well if their body can convert it properly.
For others, especially with ongoing fatigue, brain fog, or a genetic variation like DIO2 or DIO3, a combination of T4 and T3, or sometimes NDT (natural desiccated thyroid), may feel more balanced.
Alongside medication, optimising nutrients (iron, selenium, zinc, vitamin D, B12, magnesium), managing stress, supporting gut and liver health, and pacing lifestyle changes can make a big difference.
The “optimal protocol” is really the one that gives you both optimal labs and good quality of life — and it usually takes some trial, fine-tuning, and a doctor who listens to symptoms, not just numbers.