03/16/2026
History was made at Holtz Children's Hospital 🧬
Three-year-old Darius McDowell became the first pediatric patient in the world to receive ITVISMA, an FDA-approved gene therapy delivered directly into the spine, to treat Spinal Muscular Atrophy (SMA).
SMA is a genetic disease that causes progressive muscle weakness, affecting a child's ability to move, breathe, and swallow. Darius, who relies on a ventilator and a feeding tube, received this groundbreaking treatment in our operating room and went home the same day.
đź’¬ "With this treatment, we have forever changed the natural history of this disease," said Dr. Roberto Lopez-Alberola, Chief of Pediatric Neurology at Holtz Children's.
Unlike the traditional IV method, this spinal delivery allows the therapy to reach the spinal cord faster, giving patients like Darius a better chance at slowing disease progression and improving their quality of life.
We have tremendous hope for Darius' future. đź’™ Read more about his story @ https://jacksonhealth.pulse.ly/ynviqfa8ci