03/22/2025
Well explained Dr. Selig.
Ceruloplasmin is a copper-carrying protein made in the liver.
It plays a critical role in copper metabolism, binding over 90% of the copper in your blood and helping transport it where it’s needed.
But it doesn’t just handle copper—it’s also an acute phase reactant, meaning its levels rise and fall in response to inflammation and physiological stress.
One major source of that stress is xenoestrogens—synthetic or environmental compounds that mimic estrogen in the body.
Metalloestrogens, the metal-based xenoestrogens, are especially damaging.
These include metals like aluminum, cadmium, and mercury, which interfere with hormones and create oxidative stress throughout the system.
When exposed to these disruptors, ceruloplasmin can spike—not because copper metabolism is improving, but because the body is reacting to stress.
The liver, where ceruloplasmin is produced, is highly sensitive to oxidative stress.
Overloads of copper or iron, especially in unbound forms, generate reactive oxygen species (ROS) through Haber-Weiss and Fenton chemistry.
These reactions are known for damaging tissues, and the liver often takes the brunt of that damage.
In these conditions, ceruloplasmin production may be altered—not because your copper levels are imbalanced, but because your liver is under duress.
That’s why we don’t rely on blood tests or serum markers like ceruloplasmin to assess mineral health.
Serum levels shift constantly with inflammation, stress, and infection.
They show what’s happening now—not what’s been happening over time.
With Hair Tissue Mineral Analysis, we assess the mineral grid at a tissue level.
HTMA reveals long-term patterns and deeper imbalances that serum tests can’t detect.
It gives us a clearer view of how the body is managing minerals like copper or iron—and whether those metals are usable or reactive.
It’s one piece of a much larger mineral puzzle.
In cases of liver stress, oxidative damage, or xenoestrogen exposure, ceruloplasmin levels may mislead unless viewed in context.
We’re not chasing numbers—we’re tracking patterns.
Dr. Robert Selig
BackToNaturalHealth.com
