01/20/2025
Day 15: As we enter the final week, we’re focusing on how diet impacts chronic diseases, starting with the number one killer of men and women: cardiovascular disease (CVD), which includes heart disease, heart attacks, and strokes.
At the core of CVD is atherosclerosis, a chronic condition where plaque builds up inside the arteries, causing them to become narrowed and stiff. This restricts blood flow and increases the risk of serious cardiovascular events.
The Steps of Atherosclerosis:
-Endothelial Damage: The thin layer of cells lining the arteries becomes damaged by factors like high blood pressure, high cholesterol, smoking, diabetes, or chronic inflammation.
-Lipid Accumulation: LDL ("bad") cholesterol particles pe*****te the damaged area, becoming trapped and oxidized, which triggers inflammation.
-Inflammatory Response: White blood cells (monocytes and macrophages) engulf the oxidized LDL, transforming into foam cells(fatty, cholesterol laden cells) that contribute to plaque.
-Plaque Formation: Foam cells, cholesterol, calcium, and debris accumulate, creating fatty deposits covered by a fibrous cap of smooth muscles..
-Artery Narrowing and Hardening: Plaque growth restricts blood flow and stiffens the arteries, reducing flexibility.
-Plaque Rupture and Blood Clot Formation: If the fibrous cap ruptures, a blood clot can form, blocking the artery or traveling downstream to lodge in another artery, leading to a heart attack or stroke.
How to Lower Your Risk of CVD:
❤️ Protect the endothelium: Manage blood pressure, cholesterol, and blood sugar; avoid smoking.
❤️ Lower LDL cholesterol: Reduce saturated fat intake; medication may be needed.
❤️ Reduce chronic inflammation: Focus on anti-inflammatory foods and lifestyle habits.
An overall healthy eating pattern is key to preventing CVD. Here’s how your diet can help:
🥩 Reduce saturated fats to decrease the atherogenic LDL particles.
🫐 Add anti-inflammatory foods such as vegetables, fruits, whole grains, healthy fats, beans, nuts, seeds, herbs, spices, tea, coffee, and even dark chocolate. (Sound familiar?)
🥬 Boost nitrate-rich foods: Leafy greens (like arugula) and beets are rich in nitrates, which convert to nitric oxide in the body. Nitric oxide relaxes blood vessels, improves blood flow, lowers blood pressure, and reduces inflammation.