04/24/2026
Most powerful neuroprotective exercises increase these 3 biomarkers with weight training, changing you at the cellular level!
BDNF, IGF-1, and Irisin. They work to increase brain plasticity, improve mitochondrial health, and muscle function!
As a medical doctor and Harvard trained educator, I study the mechanisms behind . It’s neurobiology you can influence. Low neurotrophin levels (like BDNF and IGF-1) are leading predictors of hippocampal atrophy and memory decline, but you can do something about it!
The evidence is clear: Resistance training is profoundly neuroprotective. It's the strongest lifestyle intervention we have to increase synaptic plasticity.
This isn’t just for younger athletes.
A 2025 meta-analysis confirmed that resistance training improves executive function, memory, and global cognition in older adults.
The Exact Lifestyle Prescription
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✅ Frequency: At least 3 sessions per week.
✅ Duration: Commit to a minimum of 20 weeks to see neurobiological changes.
✅ Volume: Perform ≥8 exercises per session.
✅ Intensity: Moderate-to-vigorous (≥70% of your 1-rep max). ✅ Rest: Optimal rest periods of 90-120 seconds between sets.
Combined with a polyphenol-rich Mediterranean or MIND Mediterranean + DASH low salt diet, this lifestyle approach is your best defense!
For precise, evidence-backed protocols to build and optimize your
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Wu & Huang (2025) — Frontiers in Psychiatry