04/01/2026
PMDD has a lot to do with inflammation. CRP is a general marker of inflammation in the body and I’m assuming they checked from your blood. One of the issues with inflammation is that your immune system from your blood and your brain are supposed to be separated by the blood brain barrier. Inflammation can breakdown the blood brain barrier in a number of different ways, so you end up with immune system material in your blood that’s also impacting your brain. Elevated CRP is not the only inflammatory marker associated with PMDD and it needs to make it through the blood brain barrier to impact mood. It’s likely that PMDD is a collection of disorders with different causes that presents similarly. So some people may be impacted by different inflammatory markers being high. The biggest issue with PMDD is the brain ignoring calm down signals from progesterone and it’s metabolites. The hormones are actually normal levels, it’s the brain that’s being finicky. I would guess that the inflammation signals to the neurons to ignore the calm down signals from progesterone and it’s metabolites. Basically saying “hey girlie, we are just too stressed out right now to calm down, no sleepy time for you! Rage woman! Rage!” PMID: 40225329 Like, Share, Follow and Subscribe for more original content by Tally Reproductive Psychiatrist, Jamie Lee Sorenson, MD on Women’s Mental Health and the Bendy Boy Mom life. Taking new patients in FL, GA, CO, and TN. All patients 12 years and older are welcome. Disclaimer: Posts are for education and entertainment only. No medical advice given. This information is for general knowledge and not meant to diagnose or treat any conditions. www.tallyrepropsych.com || info@tallyrepropsych.com ll
Like, Share, Follow and Subscribe for more original content by Tally Reproductive Psychiatrist, Jamie Lee Sorenson, MD on Women’s Mental Health and the Bendy Boy Mom life.
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