04/24/2026
🤔Creatine is one of the most popular supplements out there
But does it work the same for everyone?
For children?
For older adults?
For vegetarians?
🧠 And does it affect the brain?
🎥 Listen to the full study video breakdown by subscribing to my YouTube
🔬A 2017 study by Solis, published in the Journal of Applied Physiology, set out to answer exactly that.
👇🏼Here’s what they did:
🔬Methods
• Participants took a placebo for 7 days, then creatine for 7 days
• Dose adjusted to body weight (~0.3 g/kg/day)
• Researchers measured creatine levels directly inside muscle and brain
Research Subjects
• Children (10–12)
• Adults (18–45, both omnivores and vegetarians)
• Older adults (62–84)
And here’s what they found.
📊Results
• Muscle creatine levels increased significantly, ranging from ~10–28%
• Brain creatine levels did not meaningfully change
• Older adults showed the strongest response
• Children also responded well to supplementation
• Vegetarians responded more than omnivores
☝🏼So…. even though everyone followed exactly the same protocol, the results were very different.
Muscle clearly responds well to creatine. The brain, at least in the short term, does not. Why?
Muscle relies heavily on dietary creatine. The brain, on the other hand, can produce its own and has more limited uptake.
Takeaway🔑
Traditional creatine loading protocols work — but the response is not the same for everyone, and not in every part of the body.
⚠️Now I know you are all wondering about the recent high dose protocols for cognition and brain health, where it’s been hypothesized highest doses might lead to increased PCr in th brain?
Im handing this discussion over to .darrencandow, who is one of the leading researchers on creatine supplementation.
☝🏼And…. Make sure you subscribe to my YouTube so you don’t miss my next breakdown on high dose creatine & brain benefits 🧠