27/08/2021
Why we could have an anti-viral against SARS COVID 2,especially for children.
Children have less severe disease than adults in general when infected with SARS COVID 2.
Children have stronger innate immunity, specifically in the ciliary epithelia of their respiratory systems.
Apparently, their advantage over adults gets much lower after day 5 of SARS- COVID 2 infection.
Why?
Two papers I read today try to answer that question and propose a possible method to prevent SARs COVID 2 from evading innate immune responses.
I’ve listed links below. They’re a little torturous to read so I’ll try to summarize, because I think this is really important.
1. Under normal circumstances our innate immune response to infection is primed when a virus enters our respiratory system (via nose, mouth)
2. A compound call MDA5 stimulates a gene that produces interferon. The interferon initiates an innate immune reaction that kills the virus before it infects the rest of the body.
3. SARS COVID 2 interferes with the production of MDA5 and thereby reduces the production of interferon.
4. The mechanism by which SARS COVID 2 interferes with MDA5 has been identified. The virus has a protein called Papain like protein (PPl) which directly inhibits MDA5 and so prevents production of interferon.
5. Although children are usually stronger during an initial attack by the virus, they’re systems can also get over run by the virus shutting down their interferon production. This seems to take about 5 days.
6. There’s an anti-viral drug in here someplace. (inhibit the PPL protein?) Any one from Merck out there?
References (for those of you who enjoy torture and would like to help me figure out if I’ve oversimplified this)
https://www.nature.com/articles/s41564-021-00884-1.pdf
https://www.nature.com/articles/s41587-021-01037-9.pdf