21/12/2025
https://www.facebook.com/100070715209372/posts/890328216667677/
...with research on the use in pregnancy and breastfeeding continuing to grow.
This 2025 study, published in Neuropharmacology, found that:
đź’ĄNAC acts by releasing cysteine, modulating glutamatergic and monoaminergic transmission, restoring glutathione levels, and promoting oxidative balance.
đź’ĄNAC reverses decreased synaptic plasticity, reduces neuroinflammation and mitochondrial dysfunction, and provides neurotrophic support
đź’ĄNAC reverses regressive plasticity and cognitive deficits in various neuropsychiatric and neurodegenerative disease models, supporting its role in maintaining healthy brain structure and function
NAC is the only FDA-approved antidote for acetaminophen (paracetamol) overdose, including in pregnancy, due to its ability to replenish glutathione and neutralize toxic metabolites. In pregnancy, NAC treatment reduces the risk of fetal toxicity by restoring maternal and fetal glutathione levels, protecting the developing fetal brain from oxidative and metabolic injury.
Other studies have shown that NAC supplementation (animal models) during pregnancy and lactation reduces oxidative stress, improves egg quality, and enhances offspring metabolic and cognitive function.
The use of NAC during pregnancy and lactation is new, and most studies are based on animal models.
Here is a whole list of 2025 studies on NAC in pregnancy you may want to check out.
PMID: 40846701
PMID: 40023441
PMID: 40481912