16/12/2025
During perimenopause, fluctuating estrogen can disrupt histamine balance.
Estrogen stimulates histamine release, and histamine in turn stimulates more estrogen — a feedback loop that can overactivate the nervous system.
Histamine isn’t just about allergies. In the brain, it’s a stimulatory neurotransmitter. When levels run high, it can show up as:
• sudden anxiety or panic
• racing thoughts
• insomnia
• heart palpitations
• feeling “wired but tired”
If anxiety feels cyclical, reactive, or worse around ovulation or before your period, histamine dysregulation may be part of the picture.
Supporting nervous system regulation, estrogen detox pathways, and histamine clearance can make a meaningful difference. 🤍
You’re not broken — your body is responding to real biochemical shifts.