08/28/2025
In conclusion, this study shows that the risk of cranial cruciate ligament disease in dogs is linked to how long they are exposed to natural s*x hormones, and the relationship isn’t simple or linear. The highest risk was seen when females were spayed before about 1054 days (just under 3 years) and males before about 805 days (a little over 2 years). These results may help define what counts as “early” spay or neuter when it comes to cranial cruciate ligament disease risk.
Veterinary reproduction specialists now recommend hormone-preserving sterilization: preventing unwanted litters & less risk of torn cruciates.
