10/16/2025
Excited to share this message about a research fellowship Grant that Team Cure Cholangio funded honoring Bill Hayes and Al Lemieux.
"I am pleased to share a new achievement in cholangiocarcinoma research, made possible by the generous support of Team Cure Cholangio. A recent publication, including Dr. Caitlin Conboy, was published in Hepatology. Her participation was made possible by the Quack Out Cholangio 5k Research Fellowship Grant honoring Bill Hayes and Al Lemieux.
Key findings include:
Identification of subtypes that are not linked to where the cancer began in the bile ducts, but do correlate with how long patients lived after surgery and how they responded to treatment.
Identification of a new potential drug target called TNK1, which was highly active in the metabolic subtype. In laboratory models, blocking TNK1 with an experimental drug (TP-5801) dramatically slowed tumor growth in that subtype but not in others—showing the promise of more precise, personalized treatment.
Finding that tumors in the immunomodulatory subtype responded best to standard chemotherapy (gemcitabine and cisplatin)"
