10/25/2025
Dr Philip sends along this nice deep dive into the science behind leucovorin and FRAT testing and is it ready for prime time/does it have a good scientific proof for a big roll out? Once again unbiasedscipod helps us understand why just bc it's making the rounds, it's probably not time yet to jump on the bandwagon with excellent science based info to back them up.
In our latest Substack, we examined the leucovorin-autism connection that's all the BUZZ in parent Facebook groups right now. The reality is that it's complicated. Leucovorin MIGHT help some autistic children who also have cerebral folate deficiency (a rare condition where folate can't get into the brain properly). But most autistic children don't have CFD. And those folate receptor antibodies are found in 55% of neurotypical kids, too.
Most research to date comes from one small group of investigators, studies rarely last more than 12 weeks, and the FDA is bypassing its own normal approval process—and we are worried that hope is outpacing evidence. We are closely monitoring and will share updates as we have them!
Read it here:
🔗https://theunbiasedscipod.substack.com/p/leucovorin-autism-and-the-fda-separating
