07/06/2023
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Now let's discuss the detailed information about health benefits of Coro Kavacham Level-2, normal as well as advanced information below... 🍁
Out of other ingredients, one ingredient of Coro Kavacham Level-2 is Centella asiatica extract.. benefits of Centella asiatica has been described below:
Centella asiatica has been used for centuries in traditional medicine systems, including Ayurveda and Traditional Chinese Medicine, for its potential health benefits.
🔹 Cognitive Function: Centella asiatica has been traditionally used as a to enhance cognitive function and . It supports the nervous system, , and enhances overall brain health. Active compounds in Centella asiatica, particularly asiaticoside and asiatic acid, have neuroprotective effects and help to improve .
🔹 Wound Healing and Skin Health: Centella asiatica and maintain skin health. The triterpenoids, such as asiaticoside and madecassoside, present in the plant are believed to the , enhance the synthesis of connective tissue, and support the healing of wounds and skin lesions.
🔹 Antioxidant and Anti-inflammatory Properties: Centella asiatica is known for its potential antioxidant and anti-inflammatory effects. The active compounds in the plant, including and , exhibit that helps protect cells from oxidative stress and damage caused by free radicals. Additionally, Centella asiatica in the body, which may have benefits for various inflammatory conditions.
🔹 Venous Insufficiency and Circulatory Health: Centella asiatica supports and improves venous insufficiency, which is characterized by poor blood flow in the veins. It is believed to , improve microcirculation, and in the legs. Centella asiatica may help to improves symptoms associated with , , and .
🔹 Anxiety and Stress Relief: Centella asiatica is considered an adaptogenic herb, meaning it may help the body cope with stress and promote a sense of calmness. Certain compounds found in Centella asiatica, including triterpenoids and asiaticoside, have and . These compounds may modulate the levels of neurotransmitters such as serotonin and GABA, which play a crucial role in mood regulation. These effects may contribute to its potential and . It supports adrenal gland's response to stress. It reduces anxiety and promotes relaxation.
🔹 Collagen Production and Skin Rejuvenation: Centella asiatica extract have been found to , an essential protein in the skin that provides structural support and elasticity. Components such as asiaticoside and madecassoside in Centella asiatica have been shown to promote the production of collagen, Increased collagen synthesis can help improve skin firmness and reduce the appearance of wrinkles and fine lines and shows and effects.
🔹 Anti-ulcer Activity: Centella asiatica has been traditionally used for the treatment of gastric ulcers. Research suggests that the plant extracts may help protect the gastric mucosa, reduce gastric acid secretion, and . The active compounds in Centella asiatica, particularly asiaticoside, are believed to play a role in its anti-ulcer activity.
🔹 Anticancer Potential: Certain components of the plant, such as asiaticoside and asiatic acid, have shown inhibitory effects on the growth of cancer cells in preclinical studies. Compounds like asiaticoside and asiatic acid have shown inhibitory effects on the growth of cancer cells in laboratory studies. These compounds may exert their effects through various mechanisms, including induction of cell cycle arrest, apoptosis (programmed cell death), and modulation of signaling pathways involved in cancer development.
🔹 Anti-inflammatory Effects on the Skin: Centella asiatica has been used traditionally to soothe and calm inflamed skin conditions, such as eczema, psoriasis, and dermatitis. Its anti-inflammatory properties may help reduce redness, itching, and irritation. The anti-inflammatory properties of Centella asiatica are attributed to the presence of triterpenoids, flavonoids, and other bioactive compounds. These components are thought to inhibit pro-inflammatory mediators, suppress immune responses, and modulate signaling pathways involved in inflammation. As a result, Centella asiatica can help , and irritation associated with inflammatory skin conditions.
Biochemical Pathways (Scientific details):
🔹 The active ingredients in Centella asiatica, such as triterpenoids, flavonoids, and asiaticoside, exert their effects through various biochemical pathways. Here are some of the key pathways involved:
1. Collagen Synthesis and Skin Rejuvenation: Components like asiaticoside and madecassoside found in Centella asiatica stimulate collagen synthesis through the activation of specific signaling pathways, including the transforming growth factor-beta (TGF-β) pathway. These compounds promote the production of collagen and other extracellular matrix components, leading to improved skin structure, firmness, and elasticity.
1(a). TGF-β Pathway: Components like asiaticoside and madecassoside found in Centella asiatica have been shown to activate the transforming growth factor-beta (TGF-β) pathway. TGF-β signaling promotes the production of collagen and other extracellular matrix components by activating collagen synthesis-related genes, such as collagen type I alpha 1 (COL1A1) and collagen type III alpha 1 (COL3A1) genes. These effects have been demonstrated in studies using human dermal fibroblasts, where Centella asiatica extracts increased collagen synthesis and improved skin tensile strength.
2. Antioxidant Pathways: The active compounds in Centella asiatica, particularly triterpenoids and flavonoids, exert antioxidant effects through multiple pathways. They can scavenge free radicals, inhibit oxidative stress, and enhance the activity of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase. These actions help reduce oxidative damage and protect cells from free radical-induced injury.
(2a). Free Radical Scavenging: The triterpenoids and flavonoids present in Centella asiatica act as potent free radical scavengers, helping to neutralize reactive oxygen species (ROS) and protect cells from oxidative damage. In vitro studies have demonstrated the ability of Centella asiatica extracts to scavenge free radicals, such as hydroxyl radicals and superoxide radicals, reducing oxidative stress.
(2b). Antioxidant Enzyme Activation: Centella asiatica extracts have been found to enhance the activity of antioxidant enzymes, including superoxide dismutase (SOD) and catalase. These enzymes help detoxify ROS and reduce oxidative stress. Studies in animal models have shown that Centella asiatica supplementation increases SOD and catalase activity, resulting in reduced lipid peroxidation and improved antioxidant defense.
3. Anti-inflammatory Pathways: Centella asiatica exerts its anti-inflammatory effects through modulation of various pathways involved in inflammation. The active compounds in Centella asiatica inhibit the production and release of pro-inflammatory mediators, such as cytokines (e.g., interleukin-1β, tumor necrosis factor-alpha) and enzymes (e.g., cyclooxygenase-2, lipoxygenase). They also suppress the activation of nuclear factor-kappa B (NF-κB), a key transcription factor involved in the inflammatory response.
(3a). Inhibition of Pro-inflammatory Mediators: Active compounds in Centella asiatica, such as triterpenoids, have been shown to inhibit the production and release of pro-inflammatory mediators. They suppress the expression of cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-alpha (TNF-α), which play key roles in promoting inflammation. In vitro studies using human cells have demonstrated that Centella asiatica extracts decrease the production of these pro-inflammatory cytokines.
(3b). NF-κB Pathway Suppression: The active compounds in Centella asiatica have been found to inhibit the activation of nuclear factor-kappa B (NF-κB), a central transcription factor involved in the inflammatory response. NF-κB regulates the expression of various inflammatory genes. Studies have shown that Centella asiatica extracts block NF-κB activation, leading to reduced inflammation. For example, in a mouse model of colitis, Centella asiatica supplementation inhibited NF-κB activation and reduced inflammatory markers.
4. Neuroprotective Pathways: Compounds like asiaticoside and asiatic acid found in Centella asiatica exhibit neuroprotective effects through multiple pathways. They can enhance the activity of antioxidant enzymes, promote nerve cell survival, and modulate signaling pathways involved in neuronal growth and plasticity, such as the brain-derived neurotrophic factor (BDNF)-mediated pathway. These actions contribute to the potential cognitive-enhancing and neuroprotective effects of Centella asiatica.
(4a). Antioxidant Enzyme Activation: Components like asiaticoside and asiatic acid in Centella asiatica have been shown to enhance the activity of antioxidant enzymes, including SOD and glutathione peroxidase (GPx). By increasing the activity of these enzymes, Centella asiatica extracts help protect neurons from oxidative stress and reduce oxidative damage. Studies using neuronal cell cultures have demonstrated the neuroprotective effects of Centella asiatica through antioxidant enzyme activation.
(4b). BDNF-Mediated Pathway: Centella asiatica extracts have been found to increase the expression and release of brain-derived neurotrophic factor (BDNF), a key neurotrophic factor involved in neuronal growth, survival, and plasticity. The upregulation of BDNF promotes the growth and differentiation of neurons and supports.
5. Wound Healing Pathways: Active compounds in Centella asiatica, including asiaticoside, play a role in the wound healing process by stimulating angiogenesis (formation of new blood vessels), collagen synthesis, and epithelialization (formation of new epithelial tissue). These effects are mediated through the activation of growth factors, such as vascular endothelial growth factor (VEGF) and TGF-β, which promote cell proliferation, migration, and tissue regeneration.
Vivek Kumar Verma (Vaidya)
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