The GUT CLUB

The GUT CLUB The Gut Club welcomes you as we learn about intestinal health as driver of general health. Through this new awareness we hope to inspire environmentalism.

Our mission: promote microbial balance via discussion, learning and support. Founded April 12, 2016. The Gut Club welcomes you to join us as we learn and share about intestinal health as driver of general health. A goal of The Gut Club is to inspire everyone to be an environmentalist...in similar fashion to Rachel Carson's Silent Spring igniting citizen science, substituting microbiota for chemicals . . . The Gut Club: Stool Test Discussion Group:
https://www.facebook.com/groups/1022924764502667/

16/11/2025

https://thegutclub.org/biomesight-gut-microbiome-test/
Discount code: THEGUTCLUB50 (provides 33% discount for single kits)
The GUT CLUB proudly promotes Biomesight testing for a broad view of the bacterial biome.

We also offer our Microbiome Balancing Private Consult:
https://thegutclub.org/microbiome-balancing-private-consult/
Our goal is to help you understand test results and expand your toolbox toward balance.

Please also join The Gut Club Stool Test Discussion Group:
https://www.facebook.com/groups/TheGutClubStoolTestDiscussionGroup/

16/11/2025

Magnesium-HP We proudly promote Magnesium-HP (pure magnesium glycinate).$15 discount and free shipping! Our discount code is GUTCLUB15The GUT CLUB takes magnesium seriously, and from a microbiota-gut-centric view. Looking at magnesium through this lens inspires magnesium supplementation, as if it we...

16/11/2025

Psoriasis is a common non-communicable chronic immune-mediated skin disease, affecting approximately 125 million people in the world. Its pathogenesis results from a combination of genetic and environmental factors. The pathogenesis of psoriasis seems to be driven by the interaction between innate i...

16/11/2025

'Human-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut–Brain Axis' (2020)
https://www.cmghjournal.org/article/S2352-345X(20)30126-0/fulltext

Let's discuss these findings in light of the latest SIDS research:
https://www.nbcnews.com/health/health-news/sudden-infant-death-syndrome-clues-possible-factors-rcna85986

https://www.facebook.com/photo?fbid=757164559800160&set=a.433819348801351

'Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits'
https://academic.oup.com/jnen/article-abstract/82/6/467/7177600?redirectedFrom=fulltext

https://pubmed.ncbi.nlm.nih.gov/37226597/

16/11/2025

2023 research:
'Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits.'

Let's discuss in light of gut microbial regulation of the serotonergic system, including 5-HT2A receptor:
'Human-Derived Bifidobacterium dentium Modulates the Mammalian Serotonergic System and Gut–Brain Axis' (2020)
https://www.facebook.com/photo?fbid=654803186702965&set=a.433819348801351

Articles about the new research:
https://www.technologynetworks.com/cell-science/news/sudden-infant-death-syndrome-may-have-a-biological-cause-376214

"The paper’s lead author, Dr. Robin Haynes, said: “Although we have identified abnormalities in the serotonin 2A/C receptor in SIDS, the relationship between the abnormalities and cause of death remains unknown. Much work remains in determining the consequence of abnormalities in this receptor in the context of a larger network [...] that protects vital functions in cardiac and respiratory control.”"
https://www.childrenshospital.org/research/researchers/robin-haynes

'Biological abnormality makes some infants vulnerable to sudden death'
https://www.news-medical.net/news/20230525/Biological-abnormality-makes-some-infants-vulnerable-to-sudden-death.aspx

NIH article:
https://www.nichd.nih.gov/newsroom/news/060623-SIDS-brain-serotonin-receptor
"The study authors believe the abnormalities underlie a vulnerability in the infant brain and may be responsible for an inability to wake up and take a breath under low oxygen conditions, such as when an infant’s mouth and nose are entrapped by bedding materials while sleeping face down."

16/11/2025

Serotonergic-Glutamatergic interplay:
"it has been demonstrated that serotonin (5-hydroxytryptamine) 2A (5-HT2A) receptors and metabotropic glutamate type 2 (mGlu2) receptors can assemble into a functional heteromeric complex and modulate each other’s function."
'Serotonin and Glutamate Interactions in Preclinical Schizophrenia Models' (2019)
https://pubs.acs.org/doi/abs/10.1021/acschemneuro.9b00044

Note: Let's continue tracking the serotonergic back to the microbiota-gut-brain axis, impacting the glutamatergic, associated with SIDS, SUDEP and injuries associated with glutamate excitotoxicity (immunoexcitotoxicity).

Full paper:
http://www.whba1990.org/uploads/4/0/1/1/4011882/logothetis_shah_gonzalez-maeso2019r.pdf

NMDAR ENCEPHALITIS and AUTISM, 2024SEROTONERGIC IMPACT ON GLUTAMATERGIC"ASD-like behaviors are induced by the hypo-serot...
16/11/2025

NMDAR ENCEPHALITIS and AUTISM, 2024
SEROTONERGIC IMPACT ON GLUTAMATERGIC

"ASD-like behaviors are induced by the hypo-serotonergic function in 5-HT1A receptor signaling through the overexpression of SERT, which is associated with hyper-glutamatergic neurotransmission and signaling in prenatal VPA mice."

"this study investigated whether dysfunction of serotonergic-glutamatergic interactions is implicated in the ASD-like behavior of prenatal VPA mice."

"Hyper-glutamatergic function"

"5-HT1A receptors are expressed on glutamatergic neurons and negatively control glutamate release [34, 35]"

"ASD-like behaviors are induced by the hypo-serotonergic function in 5-HT1A receptor signaling through the overexpression of SERT, which is associated with hyper-glutamatergic neurotransmission and signaling in prenatal VPA mice."

"Optogenetic activation of the serotonergic neuronal system attenuated impairments in social behavior and object recognition memory in prenatal VPA mice."

'Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HT1A receptor signaling in the prefrontal cortex in mice exposed to prenatal valproic acid' (October 2024)
https://www.nature.com/articles/s41386-024-02004-z

Second image:
'Putting out a brain on fire'
https://www.cshl.edu/putting-out-a-brain-on-fire/
(anti-N-methyl-D-aspartate receptor (anti-NMDAR) antibodies, associated with autoimmune brain inflammation.)

Note: Our 2015 article discusses serotonergic impact on glutamatergic of gut origin using SIDS as example:
https://greenmedinfo.com/blog/vaccine-injury-first-gut-then-brain

16/11/2025

The significance of the microbiota-gut-brain axis has been increasingly recognized as a major modulator of autoimmunity. Here, we aim to characterize the gut microbiota of a large cohort of treatment-naïve anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis patients relative to that of hea...

16/11/2025

ObjectiveWe aimed to investigate the associations between the intestinal microbiota, metabolites, cytokines, and clinical severity in anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis and to further determine the predictive value of the intestinal microbiota or metabolites in clinical prognosi...

16/11/2025

Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a type of autoimmune encephalitis. The underlying mechanism(s) remain largely unknown. Recent evidence has indicated that the gut microbiome may be involved in neurological immune diseases via the "gut-brain axis". This study aime...

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The Gut Club welcomes you to join us as we learn and share about intestinal health as driver of general health. A goal of The Gut Club is to inspire everyone to become an environmentalist in similar fashion to Rachel Carson's “Silent Spring” igniting citizen science, substituting microbiota for chemicals. We promote microbial DNA stool testing and help with interpretation of results. The Gut Club: Stool Test Discussion Group: https://www.facebook.com/groups/1022924764502667/