Genetic Genie: Free Raw DNA Data Analysis and MTHFR

12/08/2023

If you have hypermobility, have you seen improvements with folate supplementation?

Hypermobility involves excessive flexibility and systemic manifestations of connective tissue fragility. We propose a folate-dependent hypermobility syndrome model based on clinical observations, and through a review of existing literature, we raise the ...

11/08/2023

Hey everyone! 🧬

A while back, we tackled a special challenge: reverse-engineering 23andMe's DNA variants with proprietary identifiers to enhance GenVue. But every challenge has its moments. We noticed inconsistencies, particularly with vital markers like BRCA and MSH2 Lynch syndrome.

Here's a little insight: 23andMe has used various chips over the years, and this can sometimes lead to data inconsistencies. Given this, we've opted to step back from these specific variants. However, the general DNA data (those with an rs #) from 23andMe is still pretty good.

If you're seeking reliable DNA insights, AncestryDNA is a solid choice. But if you want the deepest of dives? Whole Genome Sequencing is unbeatable.

Thanks for riding along with us on this DNA journey! 😊

P.S.

We've recently made GenVue easier to understand for beginners by adding new variant annotations. Check it out:

Upload raw data from AncestryDNA, 23andMe, or upload a Whole Genome Sequencing (WGS/WES) file in .vcf.gz or .vcf format (1 GB max file size) to learn about conditions, drug/chemical response, rare mutations, and more. If you have multiple VCF files, SNP and Indel files are compatible. No information...

17/10/2021

Will genetic screening of embryos reduce disease in future generations or result in 'techno-eugenics'?

Like it or not, embryonic screening will likely become very common in the near future.

The first child born using the technique arrived last year. But can it really help reduce diseases in a new generation, or is it ‘techno-eugenics’?

14/08/2021

"There is a clear trend toward the worldwide prevalence of MTHFR 677 T and COVID-19 incidence and mortality."

Correlation is not necessarily causation. An interesting correlation but more studies are needed.

Background Homocysteine assessment has been proposed as a potential predictive biomarker for the severity of COVID-19 infection. The purpose of this review was to analyze the correlation between the...

17/05/2020

Are you lactose intolerant? 🥛🍪🐄

Did you know that 65% of the Human population has a reduced ability to digest lactose after infancy? Inversely, only about 5% of people in Northern European descent are lactose intolerant. But when you look at the Chinese population, over 90% are lactose intolerant. How can this be? It’s because o...

12/05/2020

Who has the best DNA raw data? We compare 23andMe, AncestryDNA, FamilyTreeDNA and MyHeritage DNA.

You may be surprised who the winner is. 🧬🤓

https://geneticgenie.org/article/23andme-ancestrydna-myheritage-whats-best-for-dna-raw-data/

Pros Cons The most mtDNA SNPs The most Y SNPs Proprietary variants A lot of miscalls Not as good as Whole Genome Sequencing The most X SNPs The most clinical (Clinvar) SNPs The most drug response SNPs Less mtDNA SNPs than 23andMe A lot of miscalls Not as good as Whole Genome Sequencing You can […]

25/04/2020

DNA Day Whole Genome Sequencing Deals

$299 (and $500 off Lifetime Access subscription) at Nebula Genomics

https://nebula.org/whole-genome-sequencing/

50% off Whole Genome Sequencing from Dante Labs (less than $300

https://us.dantelabs.com/collections/advanced-dna-tests

(This post is not sponsored and we do not receive commission on the above links)

04/03/2020

"Consumer DNA-testing firms are closing up shop and cutting jobs as a lull in sales forces the industry to move beyond the genealogy tests that turned a handful of well-funded companies into household names."

Consumer DNA-testing firms are closing up shop and cutting jobs as a lull in sales forces the industry to move beyond the genealogy tests that turned a handful of well-funded

27/01/2020

"Researchers found that less than 5% of youth in the study who tested positive for ME/CFS had been previously diagnosed with the illness."

Most youth living with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have not been diagnosed, according to a new prevalence study.

26/01/2020

https://techstartups.com/2020/01/23/beginning-end-23andme-home-dna-testing-startup-lay-off-14-percent-staff-dna-test-sales-decline-ceo-caught-off-guard-slowdown-consumer-dna/

TechStartups - Coverage of Technology News, technology startups, Emerging technology, venture capital funding, and Silicon Valley

19/01/2020

"With high sensitivity, there are at least three separate sets of genes that may play a role — and different highly sensitive people may have some or all of them. Interestingly, every single one of these genes affects your brain or nervous system."

Although rare, your high sensitivity may be an evolutionary advantage.