Biopharma PEG Scientific Inc.

01/07/2026

PD-L1 ADCs are moving fast—and changing the game in oncology.

PD-L1 has long been a proven immunotherapy target. Now, pairing it with ADC technology is opening a new chapter.

Think of them as a guided missile:
🎯 precise tumor targeting
💥 potent payload delivery
🧬 immune activation — all in one molecule

Clinical progress is real:
◆ SGN-PDL1V advancing into Phase 3
◆ HLX43 showing strong responses, even in hard-to-treat subgroups
◆ Bispecific PD-L1 ADCs aiming to break free from single-biomarker limits

This isn’t just an upgrade of immunotherapy — it’s a shift toward multi-mechanism cancer drugs designed for tumor complexity and heterogeneity.
Learn More: https://www.biochempeg.com/article/456.html

Biopharma PEG provides high-quality PEG derivatives and custom linkers that are essential for safer, more effective ADCs — especially in PD-L1 ADC development.

12/31/2025

Happy New Year! Thank you to all our clients and partners for a great year. Wishing you success and growth in the year ahead.
#2026

11/24/2025

🦃 Happy Thanksgiving from Biopharma PEG 🧡

As Thanksgiving arrives, we just want to say a genuine thank you.
Thank you for your trust, your projects, and the chance to grow together this year.

To support your work through the holiday season, our PEGs are:
✅ High purity (>95%) with low impurities
✅ Available from gram to kilogram scale
✅ Offered at a fair, competitive price

If you’re planning your next order or scaling up, we’re here to help make things a little easier.

👉 Learn more: http://www.biochempeg.com/
📩 Email us anytime at sales@biochempeg.com

Wishing you a warm, restful, and happy from all of us at Biopharma PEG. 🧡

09/25/2025

💡 AI + Nanomedicine: Unlocking Brain-Targeted mRNA Delivery
A groundbreaking study in ACS Nano presents an AI-validated framework for engineering brain-targeted lipid nanoparticles (BT-LNPs), designed to cross the blood–brain barrier (BBB) and achieve selective neuronal transfection.

🔬 How it works:
The team created a library of BT-LNPs formulated with:
● SM-102 (ionizable lipid, also used in COVID-19 vaccines)
● DOPE & cholesterol
● PEG-lipids (DMG-PEG1000 and DMG-PEG2000)
👉 Importantly, DMG-PEG2000 was conjugated to small molecules (e.g., acetylcholine, glucose, ni****ne), enabling receptor interactions for BBB crossing.
👉 To balance stability and cellular uptake, shorter PEG chains like DMG-PEG1000 were included, reducing steric hindrance and enhancing targeting efficiency.

✨ Key Outcomes:
🟩 Acetylcholine-modified LNPs showed a 3.6-fold increase in brain transfection vs. untargeted LNPs.
🟩 Human iPSC-derived BBB and brain organoid models confirmed successful neuron transfection.
🟩 AI-based predictions aligned with in vivo results, accelerating discovery and reducing animal testing.

This work highlights a scalable, modular platform for precision CNS gene therapies, with enormous potential for treating neurodegenerative diseases.

😄 We are proud that DMG-PEG1000 and DMG-PEG2000, essential PEG-lipids for LNP formulation, are available from Biopharma PEG.

🔗 Learn more: https://www.biochempeg.com/product/mPEG-DMG.html

📖 Full article: https://doi.org/10.1021/acsnano.4c15013

09/22/2025

🚀 ADC Market & Pipeline Update – H1 2025
Antibody-drug conjugates (ADCs) remain one of the fastest-growing areas in oncology.
🔹 As of today, 19 ADCs are approved worldwide.
🔹 In H1 2025, global ADC sales reached ~$8B, with full-year sales expected to surpass $16B.
🔹 Leading products like Enhertu, Padcev, Kadcyla, Polivy, Adcetris, and Trodelvy all reported strong performances.

At the same time, innovation in the pipeline continues:
🔹 200+ clinical-stage ADCs globally, targeting 50+ antigens
🔹 41 ADCs in Phase III, including emerging targets such as HER3, B7-H3, CLDN18.2, ROR1
🔹 Bispecific ADCs (e.g., EGFR/HER3, CD3/CD7) entering late-stage trials
🔹 Expansion into rare cancers, refractory tumors, and even non-oncology diseases
🔹 Ongoing payload and linker innovation, including DXd-based payloads and peptide linkers

👉 Read our full article for a deep dive into H1 2025 ADC sales performance and the Phase III pipeline shaping the future of targeted therapies: https://www.biochempeg.com/article/447.html

09/16/2025

💡 Biomimetic Nanoparticles to Combat Intracellular Bacteria

Researchers at Kumamoto University developed silver-loaded poly(lactic-co-glycolic) nanoparticles (Ag-P NPs), surface-modified with polyethyleneimine (Ag-PP NPs) and fused with Salmonella Typhimurium membrane vesicles (MVs) to form Ag-PP@MV NPs.
🔬 The MV modification enhanced cellular uptake by macrophages and achieved an ~20% reduction of intracellular S. Typhimurium, while maintaining sustained Ag⁺ release. This demonstrates the potential of MV-coated nanoparticles for treating persistent intracellular bacterial infections
😄 Proud to note that SH-PEG-COOH (5000 Da) used in this study was purchased from Biopharma PEG Scientific Inc. (Watertown, MA, USA).
📖 Read more: https://doi.org/10.3390/ma18153470
👉 SH-PEG-COOH 5K: https://www.biochempeg.com/product/SH-PEG-COOH.html

Salmonella enterica serovar Typhimurium (S. Typhimurium) is an intracellular pathogen capable of surviving and replicating within macrophages, which causes foodborne diseases such as gastroenteritis. To develop a strategy against intracellular bacteria in macrophages, we designed silver-loaded biode...

09/11/2025

PEG Linkers in Antibody-Drug Conjugates (ADCs)

To date, 19 ADCs have been approved worldwide, and 3 of them employ PEG linkers to improve stability, solubility, and delivery:

◇ Trodelvy® (Sacituzumab govitecan) – PEGylated cleavable linker
◇ Zynlonta® (Loncastuximab tesirine) – PEG8 spacer in the linker
◇ Jiataile® (Sacituzumab tirumotecan, China) – CL2A linker incorporating PEG8

PEG linkers play a critical role in ADC design by enhancing pharmacokinetics, reducing aggregation, and enabling higher DARs.

At Biopharma PEG, we provide high-purity PEG linkers (impurities

08/18/2025

🚀 PROTAC Therapies: From Concept to Late-Stage Clinical Reality

Proteolysis-targeting chimeras (PROTACs) are transforming the drug development landscape. While no PROTAC-based therapies have yet reached the market, the field is rapidly advancing:

🔬 40+ PROTAC drug candidates are now in clinical trials.
🎯 Targets include AR, ER, BTK, and IRAK4.
🩺 Applications span hematological cancers, solid tumors, and autoimmune disorders.

Notably, three PROTACs have advanced to Phase 3 trials:

√ ARV-471 (Vepdegestrant) – Arvinas/Pfizer (ER degrader) → NDA accepted by FDA, PDUFA: June 5, 2026
√ BMS-986365 – Bristol Myers Squibb (AR degrader)
√ BGB-16673 – BeiGene (BTK degrader)

🌟 With multiple late-stage programs and broad therapeutic potential, PROTACs are on the brink of becoming a new drug class in modern medicine.

👉 Do you think the first FDA-approved PROTAC will arrive by 2026?
https://www.biochempeg.com/article/434.html

07/30/2025

🔹 Y-shape-PEG-NHS, also known as 2-Arm PEG-NHS, this branched PEG derivative features NHS esters at the end of each arm—perfect for efficient, targeted conjugation to amine groups on proteins, peptides, or other biomolecules.
Its unique Y-shaped design enables:
✅ Strong, stable amide bond formation
✅ Enhanced crosslinking for hydrogel networks
✅ Applications in tissue engineering & controlled drug release
At Biopharma PEG, we provide high-purity PEG derivatives—from lab-scale to commercial batches—designed to support your R&D success.
📩 Let’s talk: sales@biochempeg.com

07/15/2025

🚀 New on our blog
Bristol Myers Squibb disclosed the structure of BMS-986238, a second-generation macrocyclic PD-L1 inhibitor.

This novel candidate showcases how strategic molecular engineering—powered by PEG technology—can unlock oral potential in peptide drugs.

🔍 Key features of BMS-986238:

• C18 fatty acid chain boosts albumin binding → significantly longer half-life
• PEG linker acts as a flexible spacer → maintains PD-L1 binding, adds solubility
• Optimized design enables both weekly subcutaneous injection and daily oral dosing

🧪 The molecule recently completed Phase 1 (NCT0668458), demonstrating strong systemic exposure and PD-L1 affinity—without relying on traditional antibodies.

At Biopharma PEG, we’re proud to support the innovation behind such molecules with:
✔️ Monodispersed and Polydispersed GMP-grade PEGs
✔️ Custom PEG linkers tailored to peptide and small molecule drug delivery
✔️ Scalable supply from mg to 100 kg

💡 Whether you're extending half-life or improving oral bioavailability, our PEG solutions help drive the next wave of therapeutic breakthroughs.

📎 Learn more: https://www.biochempeg.com/article/441.html
📩 Contact: sales@biochempeg.com

07/08/2025

🚀 Featured PEGs at Biopharma PEG!

Looking for high-purity monodispersed or polydispersed PEGs for your next project?

Whether you need grams for R&D or 100+ kilograms for GMP production, we've got your supply chain covered.

🔬 Explore our full PEG lineup: https://www.biochempeg.com/
📧 Contact us: sales@biochempeg.com

06/24/2025

HER3-DXd is out—but HER3-targeted cancer therapy is moving forward.

At ASCO 2025:
✅ Zenocutuzumab approved for NRG1+ NSCLC
✅ BL-B01D1 shows 69.2% ORR in tough NSCLC cases
✅ DB-1310 shows promise in EGFR-mutant NSCLC

The future may belong to bispecifics and ADC combos.

Patritumab deruxtecan (HER3-DXd) withdrawal marks a setback in NSCLC. Learn about successful HER3 strategies like Zenocutuzumab and promising bispecific ADCs.